Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Scn1b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SCN1B
- Mouse genes Scn1b
- Rat genes Scn1b
- Zfish genes scn1ba,scn1bb,si:ch211-225p5.8
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SCN1B	IPI	UniProtKB:Q9UQD0	Human	PMID:26900580
Molecular Function	GO:0005515	protein binding	SCN1B	IPI	UniProtKB:P35499	Human	PMID:30190309
Molecular Function	GO:0005515	protein binding	Scn1b	IPI	PR:Q8C8R3	Mouse	PMID:15272007
Molecular Function	GO:0005515	protein binding	Scn1b	IPI	PR:P15116	Mouse	PMID:15272007
Molecular Function	GO:0005515	protein binding	Scn1b	IPI	UniProtKB:P21707	Rat	PMID:10737807\|RGD:8553647
Molecular Function	GO:0005515	protein binding	Scn1b	IPI	RGD:3637	Rat	PMID:11238277\|RGD:6484234
Molecular Function	GO:0005515	protein binding	Scn1b	IPI	UniProtKB:P97685	Rat	PMID:11470829\|RGD:13825432
Molecular Function	GO:0005515	protein binding	Scn1b	IPI	RGD:68393	Rat	PMID:18565539\|RGD:6484256
Molecular Function	GO:0005515	protein binding	Scn1b	IPI	RGD:68394	Rat	PMID:18565539\|RGD:6484256
Molecular Function	GO:0019871	sodium channel inhibitor activity	Scn1b	IMP		Mouse	MGI:MGI:3763979\|PMID:17884088
Molecular Function	GO:0017080	sodium channel regulator activity	SCN1B	IDA		Human	PMID:18464934
Molecular Function	GO:0017080	sodium channel regulator activity	SCN1B	IDA		Human	PMID:19710327
Molecular Function	GO:0017080	sodium channel regulator activity	SCN1B	IDA		Human	PMID:19808477
Molecular Function	GO:0017080	sodium channel regulator activity	SCN1B	IDA		Human	PMID:8125980
Molecular Function	GO:0017080	sodium channel regulator activity	Scn1b	IDA		Rat	PMID:17517192\|RGD:2317304
Molecular Function	GO:0017080	sodium channel regulator activity	Scn1b	IDA		Rat	PMID:28012039\|RGD:13825439
Molecular Function	GO:0005248	voltage-gated sodium channel activity	SCN1B	IDA		Human	PMID:19808477
Molecular Function	GO:0005248	voltage-gated sodium channel activity	scn1ba	IGI	ZFIN:ZDB-GENE-000828-1	Zfish	PMID:17623064
Molecular Function	GO:0005248	voltage-gated sodium channel activity	scn1ba	IDA		Zfish	PMID:17623065
Molecular Function	GO:0005248	voltage-gated sodium channel activity	scn1bb	IMP	ZFIN:ZDB-MRPHLNO-090408-1	Zfish	PMID:19020043
Molecular Function	GO:0005248	voltage-gated sodium channel activity	scn1bb	IMP	ZFIN:ZDB-MRPHLNO-090408-2	Zfish	PMID:19020043
Molecular Function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	SCN1B	IMP		Human	PMID:19808477
Molecular Function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	Scn1b	IMP		Mouse	MGI:MGI:3763979\|PMID:17884088
Molecular Function	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential	SCN1B	IMP		Human	PMID:18464934
Cellular Component	GO:0014704	intercalated disc	Scn1b	IDA		Mouse	PMID:15272007
Cellular Component	GO:0014704	intercalated disc	Scn1b	IDA		Mouse	PMID:18178574
Cellular Component	GO:0043209	myelin sheath	scn1bb	IDA		Zfish	PMID:19020043
Cellular Component	GO:0043025	neuronal cell body	scn1bb	IDA		Zfish	PMID:19020043
Cellular Component	GO:0033268	node of Ranvier	Scn1b	IDA		Mouse	PMID:15102918
Cellular Component	GO:0033268	node of Ranvier	Scn1b	IDA		Rat	PMID:11470829\|RGD:13825432
Cellular Component	GO:0005886	plasma membrane	SCN1B	IDA		Human	PMID:19710327
Cellular Component	GO:0005886	plasma membrane	SCN1B	IDA		Human	PMID:30190309
Cellular Component	GO:0005886	plasma membrane	Scn1b	IDA		Rat	PMID:11470829\|RGD:13825432
Cellular Component	GO:0034706	sodium channel complex	Scn1b	IPI	UniProtKB:Q9WTU3	Mouse	PMID:15272007
Cellular Component	GO:0034706	sodium channel complex	Scn1b	IPI	PR:Q9JJV9	Mouse	PMID:15272007
Cellular Component	GO:0034706	sodium channel complex	Scn1b	IPI	UniProtKB:A2APX8	Mouse	PMID:15272007
Cellular Component	GO:0030315	T-tubule	Scn1b	IDA		Mouse	PMID:18178574
Cellular Component	GO:0030315	T-tubule	Scn1b	IDA		Mouse	PMID:15272007
Cellular Component	GO:0001518	voltage-gated sodium channel complex	SCN1B	IDA		Human	PMID:19808477
Cellular Component	GO:0001518	voltage-gated sodium channel complex	SCN1B	IDA		Human	PMID:21051419
Cellular Component	GO:0001518	voltage-gated sodium channel complex	SCN1B	IDA		Human	PMID:30190309
Cellular Component	GO:0001518	voltage-gated sodium channel complex	SCN1B	IDA		Human	PMID:8125980
Cellular Component	GO:0001518	voltage-gated sodium channel complex	Scn1b	IDA		Rat	PMID:1375395\|RGD:729871
Cellular Component	GO:0001518	voltage-gated sodium channel complex	Scn1b	IDA		Rat	PMID:28012039\|RGD:13825439
Biological Process	GO:0007411	axon guidance	Scn1b	IMP	MGI:MGI:3043422	Mouse	PMID:18354028
Biological Process	GO:0061337	cardiac conduction	Scn1b	IMP		Mouse	MGI:MGI:3763979\|PMID:17884088
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	SCN1B	IMP		Human	PMID:19808477
Biological Process	GO:0060048	cardiac muscle contraction	SCN1B	IMP		Human	PMID:19808477
Biological Process	GO:0007155	cell adhesion	scn1bb	IMP	ZFIN:ZDB-MRPHLNO-090408-1	Zfish	PMID:19020043
Biological Process	GO:0007155	cell adhesion	scn1bb	IMP	ZFIN:ZDB-MRPHLNO-090408-2	Zfish	PMID:19020043
Biological Process	GO:0021966	corticospinal neuron axon guidance	Scn1b	IMP	MGI:MGI:3043422	Mouse	PMID:18354028
Biological Process	GO:0040011	locomotion	Scn1b	IMP	MGI:MGI:3043422	Mouse	PMID:15102918
Biological Process	GO:0051899	membrane depolarization	SCN1B	IDA		Human	PMID:21051419
Biological Process	GO:0086012	membrane depolarization during cardiac muscle cell action potential	Scn1b	IMP		Mouse	MGI:MGI:3763979\|PMID:17884088
Biological Process	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential	SCN1B	IMP		Human	PMID:18464934
Biological Process	GO:0031175	neuron projection development	Scn1b	IGI	MGI:MGI:105980	Mouse	PMID:18354028
Biological Process	GO:0031175	neuron projection development	Scn1b	IGI	MGI:MGI:95602	Mouse	PMID:18354028
Biological Process	GO:0019227	neuronal action potential propagation	Scn1b	IMP	MGI:MGI:3043422	Mouse	PMID:15102918
Biological Process	GO:0010976	positive regulation of neuron projection development	Scn1b	IGI	MGI:MGI:105980	Mouse	PMID:18354028
Biological Process	GO:0010976	positive regulation of neuron projection development	Scn1b	IGI	MGI:MGI:95602	Mouse	PMID:18354028
Biological Process	GO:0010765	positive regulation of sodium ion transport	SCN1B	IDA		Human	PMID:19808477
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	SCN1B	IMP		Human	PMID:19808477
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	SCN1B	IMP		Human	PMID:22247482
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	SCN1B	IMP		Human	PMID:19808477
Biological Process	GO:2000649	regulation of sodium ion transmembrane transporter activity	SCN1B	IDA		Human	PMID:19808477
Biological Process	GO:0002028	regulation of sodium ion transport	Scn1b	IDA		Rat	PMID:1375395\|RGD:729871
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	Scn1b	IMP		Mouse	MGI:MGI:3763979\|PMID:17884088
Biological Process	GO:1905150	regulation of voltage-gated sodium channel activity	Scn1b	IDA		Rat	PMID:28012039\|RGD:13825439
Biological Process	GO:0046684	response to pyrethroid	Scn1b	IDA		Rat	PMID:19026681\|RGD:2317302
Biological Process	GO:0035725	sodium ion transmembrane transport	SCN1B	IDA		Human	PMID:18464934
Biological Process	GO:0035725	sodium ion transmembrane transport	SCN1B	IDA		Human	PMID:19808477
Biological Process	GO:0035725	sodium ion transmembrane transport	SCN1B	IDA		Human	PMID:21051419
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn1b	IMP		Mouse	MGI:MGI:3763979\|PMID:17884088
Biological Process	GO:0006814	sodium ion transport	scn1ba	IGI	ZFIN:ZDB-GENE-000828-1	Zfish	PMID:17623064
Biological Process	GO:0006814	sodium ion transport	scn1bb	IMP	ZFIN:ZDB-MRPHLNO-090408-1	Zfish	PMID:19020043
Biological Process	GO:0006814	sodium ion transport	scn1bb	IMP	ZFIN:ZDB-MRPHLNO-090408-2	Zfish	PMID:19020043

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.