Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Scn2a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SCN2A
- Mouse genes Scn2a
- Rat genes Scn2a
- Zfish genes scn1lab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043522	leucine zipper domain binding	Scn2a	IPI	RGD:1303071	Rat	PMID:17360357\|RGD:2317301
Molecular Function	GO:0005515	protein binding	Scn2a	IPI	UniProtKB:P21707	Rat	PMID:10737807\|RGD:8553647
Molecular Function	GO:0005515	protein binding	Scn2a	IPI	UniProtKB:P07463	Rat	PMID:21439835\|RGD:13432231
Molecular Function	GO:0031402	sodium ion binding	Scn2a	IDA		Rat	PMID:15664695\|RGD:1599536
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Scn2a	IDA		Rat	PMID:25615535\|RGD:13702364
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Scn2a	IMP		Rat	PMID:25615535\|RGD:13702364
Molecular Function	GO:0005248	voltage-gated sodium channel activity	SCN2A	IMP		Human	PMID:28256214
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn2a	IMP		Mouse	MGI:MGI:2179539\|PMID:10827969
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn2a	IDA		Mouse	PMID:10827969
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn2a	IDA		Rat	PMID:15664695\|RGD:1599536
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn2a	IDA		Rat	PMID:24297919\|RGD:8554774
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn2a	IDA		Rat	PMID:2442385\|RGD:1299025
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn2a	IDA		Rat	PMID:28029095\|RGD:14390052
Cellular Component	GO:0030424	axon	Scn2a	IDA		Mouse	PMID:17928448
Cellular Component	GO:0030424	axon	Scn2a	IDA		Rat	PMID:22473424\|RGD:10411906
Cellular Component	GO:0043194	axon initial segment	Scn2a	IDA		Rat	PMID:12036953\|RGD:625497
Cellular Component	GO:0098978	glutamatergic synapse	Scn2a	IDA		Mouse	PMID:22528969
Cellular Component	GO:0014704	intercalated disc	Scn2a	IDA		Mouse	PMID:15746173
Cellular Component	GO:0016020	membrane	Scn2a	IDA		Mouse	PMID:10827969
Cellular Component	GO:0016020	membrane	Scn2a	IDA		Mouse	PMID:17537961
Cellular Component	GO:0043005	neuron projection	Scn2a	IDA		Rat	PMID:12036953\|RGD:625497
Cellular Component	GO:0033268	node of Ranvier	Scn2a	IDA		Rat	PMID:16652168\|RGD:8553545
Cellular Component	GO:0033270	paranode region of axon	Scn2a	IDA		Mouse	PMID:16723544
Cellular Component	GO:0005886	plasma membrane	Scn2a	IDA		Mouse	MGI:MGI:2179539\|PMID:10827969
Cellular Component	GO:0005886	plasma membrane	Scn2a	IDA		Rat	PMID:24297919\|RGD:8554774
Cellular Component	GO:0005886	plasma membrane	Scn2a	IDA		Rat	PMID:28029095\|RGD:14390052
Cellular Component	GO:0042734	presynaptic membrane	Scn2a	IDA		Mouse	PMID:22528969
Cellular Component	GO:0034706	sodium channel complex	Scn2a	IDA		Rat	PMID:24297919\|RGD:8554774
Cellular Component	GO:0030315	T-tubule	Scn2a	IDA		Mouse	PMID:15746173
Cellular Component	GO:0001518	voltage-gated sodium channel complex	Scn2a	IDA		Rat	PMID:15664695\|RGD:1599536
Cellular Component	GO:0001518	voltage-gated sodium channel complex	Scn2a	IDA		Rat	PMID:2442385\|RGD:1299025
Biological Process	GO:0061564	axon development	Scn2a	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0071456	cellular response to hypoxia	Scn2a	IDA		Rat	PMID:28029095\|RGD:14390052
Biological Process	GO:0021987	cerebral cortex development	Scn2a	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0022038	corpus callosum development	Scn2a	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress	Scn2a	IMP	MGI:MGI:2180186	Mouse	PMID:10827969
Biological Process	GO:0007613	memory	Scn2a	IMP		Mouse	MGI:MGI:6196843\|PMID:29867081
Biological Process	GO:0042552	myelination	Scn2a	IEP		Rat	PMID:16652168\|RGD:8553545
Biological Process	GO:0007399	nervous system development	Scn2a	IMP	MGI:MGI:2180186	Mouse	PMID:10827969
Biological Process	GO:0051402	neuron apoptotic process	Scn2a	IMP	MGI:MGI:2180186	Mouse	PMID:10827969
Biological Process	GO:0019228	neuronal action potential	Scn2a	IDA		Rat	PMID:15664695\|RGD:1599536
Biological Process	GO:0019228	neuronal action potential	Scn2a	IDA		Rat	PMID:15917456\|RGD:2289019
Biological Process	GO:0019228	neuronal action potential	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:24002024
Biological Process	GO:0021554	optic nerve development	Scn2a	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0042752	regulation of circadian rhythm	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:28812061
Biological Process	GO:0006110	regulation of glycolytic process	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:27066534
Biological Process	GO:1904059	regulation of locomotor rhythm	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:28812061
Biological Process	GO:0002082	regulation of oxidative phosphorylation	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:27066534
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn2a	IMP		Mouse	MGI:MGI:2179539\|PMID:10827969
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn2a	IDA		Rat	PMID:24297919\|RGD:8554774
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn2a	IDA		Rat	PMID:28029095\|RGD:14390052
Biological Process	GO:0006814	sodium ion transport	Scn2a	IDA		Mouse	PMID:10827969
Biological Process	GO:0006814	sodium ion transport	Scn2a	IDA		Rat	PMID:2442385\|RGD:1299025
Biological Process	GO:0036269	swimming behavior	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:24002024
Biological Process	GO:0099536	synaptic signaling	scn1lab	IMP	ZFIN:ZDB-GENO-161012-2	Zfish	PMID:27305978

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.