Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCN2B
  • Mouse genes Scn2b
  • Rat genes Scn2b
  • Zfish genes scn2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Scn2b	IPI	RGD:3637	Rat	PMID:11238277|RGD:6484234
Molecular Function	GO:0017080	sodium channel regulator activity	SCN2B	IDA		Human	PMID:19808477
Molecular Function	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	Scn2b	IMP	MGI:MGI:2451362	Mouse	PMID:27932425
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn2b	IDA		Rat	PMID:8521473|RGD:729729
Molecular Function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	SCN2B	IMP		Human	PMID:19808477
Molecular Function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	Scn2b	IMP	MGI:MGI:2451362	Mouse	PMID:27932425
Cellular Component	GO:0030315	T-tubule	Scn2b	IDA		Mouse	PMID:27932425
Cellular Component	GO:0001518	voltage-gated sodium channel complex	SCN2B	IDA		Human	PMID:19808477
Biological Process	GO:0061337	cardiac conduction	Scn2b	IMP	MGI:MGI:2451362	Mouse	PMID:27932425
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	SCN2B	IMP		Human	PMID:19808477
Biological Process	GO:0060048	cardiac muscle contraction	SCN2B	IMP		Human	PMID:19808477
Biological Process	GO:0010467	gene expression	Scn2b	IMP		Mouse	PMID:16870743
Biological Process	GO:0086012	membrane depolarization during cardiac muscle cell action potential	SCN2B	IMP		Human	PMID:19808477
Biological Process	GO:0007399	nervous system development	Scn2b	IEP		Rat	PMID:19269275|RGD:2317312
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	SCN2B	IMP		Human	PMID:19808477
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	SCN2B	IMP		Human	PMID:19808477
Biological Process	GO:2000649	regulation of sodium ion transmembrane transporter activity	SCN2B	IDA		Human	PMID:19808477
Biological Process	GO:0009408	response to heat	Scn2b	IMP		Mouse	PMID:16870743
Biological Process	GO:0046684	response to pyrethroid	Scn2b	IDA		Rat	PMID:19026681|RGD:2317302
Biological Process	GO:0035725	sodium ion transmembrane transport	SCN2B	IDA		Human	PMID:19808477
Biological Process	GO:0006814	sodium ion transport	Scn2b	IMP		Mouse	PMID:16870743

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern