Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCN3A
  • Mouse genes Scn3a
  • Rat genes Scn3a
  • Zfish genes scn1lab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005516	calmodulin binding	Scn3a	IDA		Rat	PMID:16912065|RGD:2317323
Molecular Function	GO:0005515	protein binding	Scn3a	IPI	RGD:621300	Rat	PMID:15317864|RGD:2317322
Molecular Function	GO:0031402	sodium ion binding	Scn3a	IDA		Rat	PMID:15664695|RGD:1599536
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn3a	IDA		Rat	PMID:15664695|RGD:1599536
Cellular Component	GO:0030424	axon	Scn3a	IDA		Rat	PMID:16966585|RGD:1581656
Cellular Component	GO:0016020	membrane	Scn3a	IDA		Mouse	PMID:17537961
Cellular Component	GO:0043025	neuronal cell body	Scn3a	IDA		Rat	PMID:16966585|RGD:1581656
Cellular Component	GO:0016528	sarcoplasm	Scn3a	IDA		Mouse	PMID:15746173
Cellular Component	GO:0001518	voltage-gated sodium channel complex	Scn3a	IDA		Rat	PMID:15664695|RGD:1599536
Biological Process	GO:0048266	behavioral response to pain	Scn3a	IMP	MGI:MGI:5505523	Mouse	PMID:24440715
Biological Process	GO:0071236	cellular response to antibiotic	Scn3a	IDA		Rat	PMID:18839021|RGD:2317318
Biological Process	GO:0007399	nervous system development	Scn3a	IEP		Rat	PMID:19269275|RGD:2317312
Biological Process	GO:0019228	neuronal action potential	Scn3a	IDA		Rat	PMID:15664695|RGD:1599536
Biological Process	GO:0019228	neuronal action potential	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:24002024
Biological Process	GO:0042752	regulation of circadian rhythm	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:28812061
Biological Process	GO:0006110	regulation of glycolytic process	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:27066534
Biological Process	GO:1904059	regulation of locomotor rhythm	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:28812061
Biological Process	GO:0002082	regulation of oxidative phosphorylation	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:27066534
Biological Process	GO:0046684	response to pyrethroid	Scn3a	IDA		Rat	PMID:19026681|RGD:2317302
Biological Process	GO:0009611	response to wounding	Scn3a	IEP		Rat	PMID:14523090|RGD:734493
Biological Process	GO:0019233	sensory perception of pain	Scn3a	IMP		Rat	PMID:14523090|RGD:734493
Biological Process	GO:0036269	swimming behavior	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:24002024
Biological Process	GO:0099536	synaptic signaling	scn1lab	IMP	ZFIN:ZDB-GENO-161012-2	Zfish	PMID:27305978

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern