Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCN9A
  • Mouse genes Scn9a
  • Rat genes Scn9a
  • Zfish genes scn1lab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn9a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031402	sodium ion binding	Scn9a	IDA		Rat	PMID:15664695|RGD:1599536
Molecular Function	GO:0005248	voltage-gated sodium channel activity	SCN9A	IDA		Human	PMID:17145499
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn9a	IDA		Rat	PMID:15664695|RGD:1599536
Cellular Component	GO:0030424	axon	Scn9a	IDA		Rat	PMID:21118538|RGD:15090835
Cellular Component	GO:0005886	plasma membrane	SCN9A	IMP		Human	PMID:17145499
Cellular Component	GO:0001518	voltage-gated sodium channel complex	Scn9a	IDA		Rat	PMID:15664695|RGD:1599536
Biological Process	GO:0061368	behavioral response to formalin induced pain	Scn9a	IMP		Rat	PMID:31550995|RGD:150429745
Biological Process	GO:0048266	behavioral response to pain	Scn9a	IMP	MGI:MGI:3053097	Mouse	PMID:24440715
Biological Process	GO:0048266	behavioral response to pain	Scn9a	IMP	MGI:MGI:3053098	Mouse	PMID:15314237
Biological Process	GO:0007623	circadian rhythm	Scn9a	IMP	MGI:MGI:3053097	Mouse	PMID:25101983
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	Scn9a	IMP	MGI:MGI:3053097	Mouse	PMID:25101983
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Scn9a	IMP	MGI:MGI:3053097	Mouse	PMID:25101983
Biological Process	GO:0006954	inflammatory response	Scn9a	IMP	MGI:MGI:3053098	Mouse	PMID:15314237
Biological Process	GO:0045759	negative regulation of action potential	Scn9a	IMP		Rat	PMID:31550995|RGD:150429745
Biological Process	GO:0019228	neuronal action potential	Scn9a	IDA		Rat	PMID:15664695|RGD:1599536
Biological Process	GO:0019228	neuronal action potential	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:24002024
Biological Process	GO:0009791	post-embryonic development	Scn9a	IMP	MGI:MGI:3053098	Mouse	PMID:15314237
Biological Process	GO:0042752	regulation of circadian rhythm	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:28812061
Biological Process	GO:0006110	regulation of glycolytic process	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:27066534
Biological Process	GO:1904059	regulation of locomotor rhythm	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:28812061
Biological Process	GO:0002082	regulation of oxidative phosphorylation	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:27066534
Biological Process	GO:0009409	response to cold	Scn9a	IMP		Rat	PMID:31550995|RGD:150429745
Biological Process	GO:0009408	response to heat	Scn9a	IMP		Rat	PMID:31550995|RGD:150429745
Biological Process	GO:0009636	response to toxic substance	Scn9a	IDA		Mouse	PMID:16029194
Biological Process	GO:0019233	sensory perception of pain	SCN9A	IMP		Human	PMID:17145499
Biological Process	GO:0035725	sodium ion transmembrane transport	SCN9A	IDA		Human	PMID:17145499
Biological Process	GO:0036269	swimming behavior	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:24002024
Biological Process	GO:0099536	synaptic signaling	scn1lab	IMP	ZFIN:ZDB-GENO-161012-2	Zfish	PMID:27305978

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern