Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCNN1B
  • Mouse genes Scnn1b
  • Rat genes Scnn1b
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scnn1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015280	ligand-gated sodium channel activity	SCNN1B	IDA		Human	PMID:24124190
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Scnn1b	IDA		Mouse	PMID:10409305
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Scnn1b	IGI	MGI:MGI:104695	Mouse	PMID:17715136
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Scnn1b	IGI	MGI:MGI:101782	Mouse	PMID:17715136
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Scnn1b	IMP		Rat	PMID:9118951|RGD:151356642
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Scnn1b	IMP		Rat	PMID:11773057|RGD:729911
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Scnn1b	IDA		Rat	PMID:16172119|RGD:1624140
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Scnn1b	IDA		Rat	PMID:16356937|RGD:1624121
Molecular Function	GO:0005515	protein binding	SCNN1B	IPI	UniProtKB:Q96PU5	Human	PMID:11244092
Molecular Function	GO:0005515	protein binding	SCNN1B	IPI	UniProtKB:P46934	Human	PMID:11359767
Molecular Function	GO:0005515	protein binding	SCNN1B	IPI	UniProtKB:Q8N668	Human	PMID:20237237
Molecular Function	GO:0005515	protein binding	SCNN1B	IPI	UniProtKB:P46934	Human	PMID:21765395
Molecular Function	GO:0005515	protein binding	SCNN1B	IPI	UniProtKB:Q8NBP7	Human	PMID:22493497
Molecular Function	GO:0005515	protein binding	Scnn1b	IPI	PR:P46935	Mouse	PMID:17544362
Molecular Function	GO:0005515	protein binding	Scnn1b	IPI	PR:Q8CFI0	Mouse	PMID:17544362
Molecular Function	GO:0005515	protein binding	Scnn1b	IPI	RGD:3157	Rat	PMID:11527431|RGD:1642065
Molecular Function	GO:0005272	sodium channel activity	Scnn1b	IDA		Mouse	PMID:16941024
Molecular Function	GO:0015081	sodium ion transmembrane transporter activity	Scnn1b	IDA		Rat	PMID:8107805|RGD:729797
Molecular Function	GO:0050699	WW domain binding	SCNN1B	IPI	UniProtKB:P46934	Human	PMID:10642508
Molecular Function	GO:0050699	WW domain binding	Scnn1b	IPI	UniProtKB:P46934	Mouse	PMID:10212229
Molecular Function	GO:0050699	WW domain binding	Scnn1b	IPI	PR:P46935	Mouse	PMID:10212229
Molecular Function	GO:0050699	WW domain binding	Scnn1b	IPI	RGD:3157	Rat	PMID:8665844|RGD:633483
Molecular Function	GO:0050699	WW domain binding	Scnn1b	IDA		Rat	PMID:9923703|RGD:2301360
Cellular Component	GO:0016324	apical plasma membrane	Scnn1b	IDA		Rat	PMID:11773057|RGD:729911
Cellular Component	GO:0016324	apical plasma membrane	Scnn1b	IDA		Rat	PMID:15075188|RGD:1624161
Cellular Component	GO:0016324	apical plasma membrane	Scnn1b	IDA		Rat	PMID:9118951|RGD:151356642
Cellular Component	GO:0009986	cell surface	Scnn1b	IDA		Rat	PMID:16476738|RGD:1624163
Cellular Component	GO:0009897	external side of plasma membrane	Scnn1b	IDA		Mouse	PMID:17715136
Cellular Component	GO:0070062	extracellular exosome	SCNN1B	IDA		Human	PMID:15326289
Cellular Component	GO:0016020	membrane	Scnn1b	IDA		Mouse	PMID:10409305
Cellular Component	GO:0016020	membrane	Scnn1b	IDA		Mouse	PMID:17715136
Cellular Component	GO:0005886	plasma membrane	SCNN1B	IDA		Human	PMID:24124190
Cellular Component	GO:0034706	sodium channel complex	SCNN1B	IDA		Human	PMID:16423824
Cellular Component	GO:0034706	sodium channel complex	SCNN1B	IPI		Human	PMID:21775436
Cellular Component	GO:0034706	sodium channel complex	SCNN1B	IDA		Human	PMID:24124190
Cellular Component	GO:0034706	sodium channel complex	Scnn1b	IDA		Mouse	PMID:32079677
Cellular Component	GO:0034706	sodium channel complex	Scnn1b	IGI	MGI:MGI:101782	Mouse	PMID:17715136
Cellular Component	GO:0034706	sodium channel complex	Scnn1b	IGI	MGI:MGI:104695	Mouse	PMID:17715136
Biological Process	GO:0032341	aldosterone metabolic process	Scnn1b	IMP		Mouse	PMID:28567665
Biological Process	GO:0014824	artery smooth muscle contraction	Scnn1b	IMP	MGI:MGI:2179831	Mouse	PMID:19553501
Biological Process	GO:0071468	cellular response to acidic pH	SCNN1B	IDA		Human	PMID:16423824
Biological Process	GO:1904045	cellular response to aldosterone	Scnn1b	IDA		Mouse	PMID:20427473
Biological Process	GO:0042045	epithelial fluid transport	Scnn1b	IMP		Mouse	PMID:18024719
Biological Process	GO:0042045	epithelial fluid transport	Scnn1b	IMP		Mouse	PMID:17430990
Biological Process	GO:0034101	erythrocyte homeostasis	Scnn1b	IMP		Mouse	PMID:28567665
Biological Process	GO:0010467	gene expression	Scnn1b	IMP		Mouse	PMID:18024719
Biological Process	GO:0010467	gene expression	Scnn1b	IMP		Mouse	PMID:28567665
Biological Process	GO:0006883	intracellular sodium ion homeostasis	SCNN1B	IDA		Human	PMID:16423824
Biological Process	GO:0006883	intracellular sodium ion homeostasis	Scnn1b	IDA		Mouse	MGI:MGI:3046390|PMID:15096495
Biological Process	GO:0006883	intracellular sodium ion homeostasis	Scnn1b	IDA		Rat	PMID:17562820|RGD:150521638
Biological Process	GO:0002269	leukocyte activation involved in inflammatory response	Scnn1b	IGI	MGI:MGI:108005	Mouse	PMID:22419116
Biological Process	GO:0002269	leukocyte activation involved in inflammatory response	Scnn1b	IDA		Mouse	PMID:22419116
Biological Process	GO:0070254	mucus secretion	Scnn1b	IDA		Mouse	PMID:22419116
Biological Process	GO:0035264	multicellular organism growth	Scnn1b	IMP		Mouse	PMID:28567665
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	SCNN1B	IDA		Human	PMID:24124190
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	Scnn1b	IMP		Mouse	PMID:17430990
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	Scnn1b	IMP		Mouse	PMID:28567665
Biological Process	GO:0002283	neutrophil activation involved in immune response	Scnn1b	IDA		Mouse	PMID:22419116
Biological Process	GO:0002283	neutrophil activation involved in immune response	Scnn1b	IGI	MGI:MGI:108005	Mouse	PMID:22419116
Biological Process	GO:0070944	neutrophil-mediated killing of bacterium	Scnn1b	IDA		Mouse	PMID:22419116
Biological Process	GO:0070944	neutrophil-mediated killing of bacterium	Scnn1b	IGI	MGI:MGI:108005	Mouse	PMID:22419116
Biological Process	GO:0055075	potassium ion homeostasis	Scnn1b	IMP		Mouse	PMID:28567665
Biological Process	GO:0002028	regulation of sodium ion transport	Scnn1b	IDA		Rat	PMID:16027156|RGD:1624162
Biological Process	GO:0003014	renal system process	Scnn1b	IMP		Mouse	PMID:28567665
Biological Process	GO:0032094	response to food	Scnn1b	IMP		Mouse	PMID:28567665
Biological Process	GO:0001666	response to hypoxia	Scnn1b	IEP		Rat	PMID:12372821|RGD:729765
Biological Process	GO:0009410	response to xenobiotic stimulus	Scnn1b	IMP		Mouse	PMID:18024719
Biological Process	GO:0009410	response to xenobiotic stimulus	Scnn1b	IMP		Mouse	PMID:17430990
Biological Process	GO:0055078	sodium ion homeostasis	SCNN1B	IDA		Human	PMID:24124190
Biological Process	GO:0055078	sodium ion homeostasis	Scnn1b	IMP		Mouse	PMID:28567665
Biological Process	GO:0098719	sodium ion import across plasma membrane	SCNN1B	IDA		Human	PMID:16423824
Biological Process	GO:0098719	sodium ion import across plasma membrane	Scnn1b	IDA		Mouse	MGI:MGI:3046390|PMID:15096495
Biological Process	GO:0098719	sodium ion import across plasma membrane	Scnn1b	IDA		Rat	PMID:17562820|RGD:150521638
Biological Process	GO:0035725	sodium ion transmembrane transport	SCNN1B	IDA		Human	PMID:24124190
Biological Process	GO:0006814	sodium ion transport	Scnn1b	IGI	MGI:MGI:101782	Mouse	PMID:16941024
Biological Process	GO:0006814	sodium ion transport	Scnn1b	IGI	MGI:MGI:101782	Mouse	PMID:17715136
Biological Process	GO:0006814	sodium ion transport	Scnn1b	IGI	MGI:MGI:104695	Mouse	PMID:16941024
Biological Process	GO:0006814	sodium ion transport	Scnn1b	IGI	MGI:MGI:104695	Mouse	PMID:17715136
Biological Process	GO:0006814	sodium ion transport	Scnn1b	IDA		Mouse	PMID:10409305
Biological Process	GO:0006814	sodium ion transport	Scnn1b	IMP		Rat	PMID:11773057|RGD:729911
Biological Process	GO:0006814	sodium ion transport	Scnn1b	IDA		Rat	PMID:15075188|RGD:1624161
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	Scnn1b	IMP		Rat	PMID:16844921|RGD:1624146

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern