Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCUBE3
  • Mouse genes Scube3
  • Rat genes Scube3
  • Zfish genes scube3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scube3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036122	BMP binding	SCUBE3	IPI	UniProtKB:P12643	Human	PMID:33308444
Molecular Function	GO:0036122	BMP binding	SCUBE3	IPI	UniProtKB:P12644	Human	PMID:33308444
Molecular Function	GO:0036122	BMP binding	SCUBE3	IPI	UniProtKB:P18075	Human	PMID:33308444
Molecular Function	GO:0070700	BMP receptor binding	SCUBE3	IPI	UniProtKB:O00238	Human	PMID:33308444
Molecular Function	GO:0070700	BMP receptor binding	SCUBE3	IPI	UniProtKB:P36894	Human	PMID:33308444
Molecular Function	GO:0070700	BMP receptor binding	SCUBE3	IPI	UniProtKB:Q13873	Human	PMID:33308444
Molecular Function	GO:0042802	identical protein binding	SCUBE3	IPI	UniProtKB:Q8IX30	Human	PMID:15234972
Molecular Function	GO:0005515	protein binding	SCUBE3	IPI	UniProtKB:Q86TI6	Human	PMID:15234972
Molecular Function	GO:0005515	protein binding	SCUBE3	IPI	UniProtKB:P08253	Human	PMID:21441952
Molecular Function	GO:0005515	protein binding	SCUBE3	IPI	UniProtKB:P14780	Human	PMID:21441952
Molecular Function	GO:0005515	protein binding	SCUBE3	IPI	UniProtKB:P37173	Human	PMID:21441952
Cellular Component	GO:0009986	cell surface	SCUBE3	IDA		Human	PMID:15234972
Cellular Component	GO:0009986	cell surface	SCUBE3	IDA		Human	PMID:33308444
Cellular Component	GO:0005886	plasma membrane	SCUBE3	IDA		Human	GO_REF:0000052
Biological Process	GO:0055001	muscle cell development	scube3	IGI	ZFIN:ZDB-MRPHLNO-050510-1,ZFIN:ZDB-MRPHLNO-120813-6,ZFIN:ZDB-MRPHLNO-120813-7	Zfish	PMID:22609552
Biological Process	GO:0055001	muscle cell development	scube3	IGI	ZFIN:ZDB-GENO-070808-35,ZFIN:ZDB-MRPHLNO-120813-7	Zfish	PMID:22609552
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	SCUBE3	IMP		Human	PMID:33308444
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	SCUBE3	IMP		Human	PMID:33308444
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Scube3	IMP		Mouse	MGI:MGI:6716484|PMID:33308444
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Scube3	IDA		Mouse	PMID:25639508
Biological Process	GO:0048741	skeletal muscle fiber development	scube3	IMP	ZFIN:ZDB-MRPHLNO-120813-7	Zfish	PMID:24849601
Biological Process	GO:0048741	skeletal muscle fiber development	scube3	IMP	ZFIN:ZDB-MRPHLNO-141002-1	Zfish	PMID:24849601
Biological Process	GO:0007224	smoothened signaling pathway	scube3	IGI	ZFIN:ZDB-MRPHLNO-050510-1,ZFIN:ZDB-MRPHLNO-120813-6,ZFIN:ZDB-MRPHLNO-120813-7	Zfish	PMID:22609552
Biological Process	GO:0007224	smoothened signaling pathway	scube3	IGI	ZFIN:ZDB-GENE-980526-166,ZFIN:ZDB-MRPHLNO-050510-1,ZFIN:ZDB-MRPHLNO-120813-6,ZFIN:ZDB-MRPHLNO-120813-7	Zfish	PMID:22609552

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern