Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Scx

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SCX
- Mouse genes Scx
- Rat genes Scx
- Zfish genes scxa,scxb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	SCX	IPI	UniProtKB:P15923	Human	PMID:10775504
Molecular Function	GO:0043425	bHLH transcription factor binding	Scx	IPI	UniProtKB:P21677	Mouse	MGI:MGI:5294531\|PMID:19828133
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Scx	IDA		Mouse	PMID:17430895
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	SCX	IDA		Human	PMID:10775504
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Scx	IDA		Mouse	MGI:MGI:72077\|PMID:7743923
Molecular Function	GO:0070888	E-box binding	SCX	IDA		Human	PMID:10775504
Molecular Function	GO:0070888	E-box binding	Scx	IDA		Mouse	MGI:MGI:5294531\|PMID:19828133
Molecular Function	GO:0070888	E-box binding	Scx	IDA		Mouse	MGI:MGI:72077\|PMID:7743923
Molecular Function	GO:0070888	E-box binding	Scx	IDA		Mouse	MGI:MGI:4418577\|PMID:20059955
Molecular Function	GO:0005515	protein binding	SCX	IPI	UniProtKB:O43639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SCX	IPI	UniProtKB:P13349	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SCX	IPI	UniProtKB:P15884-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Scx	IPI	UniProtKB:Q9QZQ0	Mouse	MGI:MGI:72077\|PMID:7743923
Molecular Function	GO:0005515	protein binding	Scx	IPI	PR:P15806	Mouse	PMID:17430895
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Scx	IDA		Mouse	MGI:MGI:72077\|PMID:7743923
Molecular Function	GO:0043565	sequence-specific DNA binding	Scx	IDA		Mouse	MGI:MGI:5294319\|PMID:9328840
Cellular Component	GO:0005634	nucleus	SCX	IDA		Human	PMID:10775504
Cellular Component	GO:0005634	nucleus	SCX	IDA		Human	PMID:19828133
Cellular Component	GO:0005634	nucleus	Scx	IDA		Mouse	MGI:MGI:5294534\|PMID:19362560
Cellular Component	GO:0005634	nucleus	Scx	IDA		Mouse	MGI:MGI:5294531\|PMID:19828133
Cellular Component	GO:0005667	transcription regulator complex	SCX	IDA		Human	PMID:10775504
Cellular Component	GO:0005667	transcription regulator complex	Scx	IDA		Mouse	MGI:MGI:5294531\|PMID:19828133
Biological Process	GO:0030509	BMP signaling pathway	Scx	IMP		Mouse	MGI:MGI:4418577\|PMID:20059955
Biological Process	GO:0030154	cell differentiation	Scx	IMP		Mouse	MGI:MGI:4413438\|PMID:18802027
Biological Process	GO:0071773	cellular response to BMP stimulus	Scx	IEP		Mouse	MGI:MGI:5294319\|PMID:9328840
Biological Process	GO:0071260	cellular response to mechanical stimulus	Scx	IEP		Mouse	MGI:MGI:5294512\|PMID:21625049
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Scx	IEP		Mouse	MGI:MGI:5294319\|PMID:9328840
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Scx	IEP		Mouse	MGI:MGI:3796269\|PMID:18498113
Biological Process	GO:0002062	chondrocyte differentiation	Scx	IMP		Mouse	MGI:MGI:4418577\|PMID:20059955
Biological Process	GO:0030199	collagen fibril organization	Scx	IMP		Mouse	MGI:MGI:4413438\|PMID:18802027
Biological Process	GO:0035993	deltoid tuberosity development	Scx	IMP		Mouse	MGI:MGI:4418577\|PMID:20059955
Biological Process	GO:0035993	deltoid tuberosity development	Scx	IMP		Mouse	MGI:MGI:3715390\|PMID:17567668
Biological Process	GO:0006351	DNA-templated transcription	Scx	IDA		Mouse	MGI:MGI:5294319\|PMID:9328840
Biological Process	GO:0048706	embryonic skeletal system development	Scx	IEP		Mouse	MGI:MGI:72077\|PMID:7743923
Biological Process	GO:0001958	endochondral ossification	Scx	IMP		Mouse	MGI:MGI:4418577\|PMID:20059955
Biological Process	GO:0060325	face morphogenesis	Scx	IEP		Mouse	MGI:MGI:3796269\|PMID:18498113
Biological Process	GO:0003188	heart valve formation	Scx	IMP		Mouse	MGI:MGI:4413438\|PMID:18802027
Biological Process	GO:0003179	heart valve morphogenesis	Scx	IMP		Mouse	MGI:MGI:4413438\|PMID:18802027
Biological Process	GO:0001707	mesoderm formation	Scx	IMP		Mouse	MGI:MGI:1343990\|PMID:10477299
Biological Process	GO:0043066	negative regulation of apoptotic process	Scx	IMP		Mouse	MGI:MGI:1343990\|PMID:10477299
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Scx	IMP		Mouse	MGI:MGI:4413438\|PMID:18802027
Biological Process	GO:0061036	positive regulation of cartilage development	Scx	IMP		Mouse	MGI:MGI:1343990\|PMID:10477299
Biological Process	GO:0008284	positive regulation of cell population proliferation	Scx	IMP		Mouse	MGI:MGI:1343990\|PMID:10477299
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Scx	IDA		Mouse	MGI:MGI:5294534\|PMID:19362560
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Scx	IMP		Mouse	MGI:MGI:4413438\|PMID:18802027
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Scx	IDA		Mouse	MGI:MGI:5294531\|PMID:19828133
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Scx	IDA		Mouse	MGI:MGI:72077\|PMID:7743923
Biological Process	GO:2000543	positive regulation of gastrulation	Scx	IMP		Mouse	MGI:MGI:1343990\|PMID:10477299
Biological Process	GO:0010628	positive regulation of gene expression	Scx	IDA		Mouse	MGI:MGI:5294531\|PMID:19828133
Biological Process	GO:0010628	positive regulation of gene expression	Scx	IMP		Mouse	MGI:MGI:4413438\|PMID:18802027
Biological Process	GO:0010628	positive regulation of gene expression	Scx	IMP		Mouse	MGI:MGI:4418577\|PMID:20059955
Biological Process	GO:0010628	positive regulation of gene expression	Scx	IDA		Mouse	MGI:MGI:5294534\|PMID:19362560
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SCX	IDA		Human	PMID:10775504
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Scx	IDA		Mouse	MGI:MGI:72077\|PMID:7743923
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Scx	IDA		Mouse	MGI:MGI:5294534\|PMID:19362560
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Scx	IDA		Mouse	MGI:MGI:4418577\|PMID:20059955
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Scx	IGI	MGI:MGI:98510	Mouse	PMID:17430895
Biological Process	GO:0061035	regulation of cartilage development	Scx	IMP		Mouse	MGI:MGI:4413438\|PMID:18802027
Biological Process	GO:0061056	sclerotome development	Scx	IEP		Mouse	MGI:MGI:72077\|PMID:7743923
Biological Process	GO:0035914	skeletal muscle cell differentiation	Scx	IMP		Mouse	PMID:22147266
Biological Process	GO:0035990	tendon cell differentiation	Scx	IMP		Mouse	MGI:MGI:4418577\|PMID:20059955
Biological Process	GO:0035990	tendon cell differentiation	Scx	IMP		Mouse	MGI:MGI:3715390\|PMID:17567668
Biological Process	GO:0035989	tendon development	Scx	IMP		Mouse	MGI:MGI:3715390\|PMID:17567668
Biological Process	GO:0035992	tendon formation	Scx	IMP		Mouse	MGI:MGI:2679803\|PMID:14568104
Biological Process	GO:0035992	tendon formation	Scx	IMP		Mouse	MGI:MGI:3715390\|PMID:17567668
Biological Process	GO:0035992	tendon formation	scxa	IMP	ZFIN:ZDB-GENO-200403-11	Zfish	PMID:31100023
Biological Process	GO:0035992	tendon formation	scxa	IGI	ZFIN:ZDB-GENO-200422-1	Zfish	PMID:31100023
Biological Process	GO:0035992	tendon formation	scxb	IGI	ZFIN:ZDB-GENO-200422-1	Zfish	PMID:31100023
Biological Process	GO:0001894	tissue homeostasis	Scx	IMP		Mouse	MGI:MGI:4413438\|PMID:18802027

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.