Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SEMA3A
  • Mouse genes Sema3a
  • Rat genes Sema3a
  • Zfish genes sema3aa,sema3ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sema3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045499	chemorepellent activity	Sema3a	IDA		Mouse	PMID:12435358
Molecular Function	GO:0045499	chemorepellent activity	Sema3a	IDA		Mouse	PMID:11683995
Molecular Function	GO:0045499	chemorepellent activity	Sema3a	IDA		Mouse	PMID:15814794
Molecular Function	GO:0038191	neuropilin binding	Sema3a	IPI	UniProtKB:P97333	Mouse	MGI:MGI:3050159|PMID:15239958
Molecular Function	GO:0005515	protein binding	Sema3a	IPI	UniProtKB:P97333	Mouse	MGI:MGI:5918310|PMID:23104057
Molecular Function	GO:0030215	semaphorin receptor binding	Sema3a	IPI	PR:P97333	Mouse	PMID:15239958
Cellular Component	GO:0030424	axon	Sema3a	IDA		Rat	PMID:15866045|RGD:1580078
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	Sema3a	IDA		Mouse	PMID:24831527
Cellular Component	GO:0150053	cerebellar climbing fiber to Purkinje cell synapse	Sema3a	IMP		Mouse	PMID:24831527
Cellular Component	GO:0030425	dendrite	Sema3a	IDA		Rat	PMID:15866045|RGD:1580078
Cellular Component	GO:0005615	extracellular space	Sema3a	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0098978	glutamatergic synapse	Sema3a	IMP		Mouse	PMID:22179111
Cellular Component	GO:0098978	glutamatergic synapse	Sema3a	IDA		Mouse	PMID:22179111
Biological Process	GO:0006915	apoptotic process	Sema3a	IMP		Rat	PMID:12376549|RGD:729827
Biological Process	GO:0048844	artery morphogenesis	sema3aa	IMP		Zfish	PMID:12783793
Biological Process	GO:0048675	axon extension	Sema3a	IDA		Mouse	PMID:12852851
Biological Process	GO:0048675	axon extension	Sema3a	IGI	MGI:MGI:106206	Mouse	PMID:12852851
Biological Process	GO:0048846	axon extension involved in axon guidance	Sema3a	IMP		Mouse	MGI:MGI:5437554|PMID:22790009
Biological Process	GO:0048846	axon extension involved in axon guidance	Sema3a	IGI	MGI:MGI:96721	Mouse	PMID:18550718
Biological Process	GO:0048846	axon extension involved in axon guidance	Sema3a	IGI	MGI:MGI:107683	Mouse	PMID:11683995
Biological Process	GO:0048846	axon extension involved in axon guidance	Sema3a	IGI	MGI:MGI:104518	Mouse	PMID:18550718
Biological Process	GO:0048846	axon extension involved in axon guidance	Sema3a	IDA		Mouse	PMID:9753685
Biological Process	GO:0048846	axon extension involved in axon guidance	Sema3a	IDA		Mouse	PMID:7748561
Biological Process	GO:0007411	axon guidance	Sema3a	IMP	MGI:MGI:2158944	Mouse	PMID:17428830
Biological Process	GO:0007411	axon guidance	Sema3a	IDA		Mouse	PMID:12435358
Biological Process	GO:0007411	axon guidance	Sema3a	IDA		Mouse	PMID:15869472
Biological Process	GO:0007411	axon guidance	Sema3a	IDA		Mouse	PMID:15814794
Biological Process	GO:0007411	axon guidance	Sema3a	IMP	MGI:MGI:2158944	Mouse	PMID:17417650
Biological Process	GO:0007411	axon guidance	Sema3a	IMP	MGI:MGI:2449920	Mouse	PMID:15604101
Biological Process	GO:0007411	axon guidance	Sema3a	IGI	UniProtKB:Q6P2A7	Rat	PMID:21068336|RGD:8554551
Biological Process	GO:0007413	axonal fasciculation	Sema3a	IMP	MGI:MGI:2158944	Mouse	PMID:17428830
Biological Process	GO:0060385	axonogenesis involved in innervation	Sema3a	IMP		Mouse	MGI:MGI:5437554|PMID:22790009
Biological Process	GO:0150020	basal dendrite arborization	Sema3a	IGI	UniProtKB:P97333	Mouse	MGI:MGI:5462161|PMID:22683681
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	sema3ab	IMP		Zfish	PMID:15239959
Biological Process	GO:0048755	branching morphogenesis of a nerve	sema3aa	IGI	ZFIN:ZDB-MRPHLNO-051129-1,ZFIN:ZDB-MRPHLNO-070613-2	Zfish	PMID:17475806
Biological Process	GO:0048755	branching morphogenesis of a nerve	sema3ab	IGI	ZFIN:ZDB-MRPHLNO-050513-4,ZFIN:ZDB-MRPHLNO-070613-2	Zfish	PMID:17475806
Biological Process	GO:0021785	branchiomotor neuron axon guidance	Sema3a	IMP		Mouse	MGI:MGI:3822054|PMID:18804103
Biological Process	GO:0016477	cell migration	sema3aa	IMP		Zfish	PMID:12783793
Biological Process	GO:0035441	cell migration involved in vasculogenesis	sema3aa	IMP		Zfish	PMID:12783793
Biological Process	GO:0048813	dendrite morphogenesis	Sema3a	IMP	MGI:MGI:2158944	Mouse	PMID:12372285
Biological Process	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching	Sema3a	IGI	MGI:MGI:106206	Mouse	PMID:17626059
Biological Process	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching	Sema3a	IDA		Mouse	PMID:17626059
Biological Process	GO:0010631	epithelial cell migration	Sema3a	IDA		Mouse	PMID:17626059
Biological Process	GO:0021612	facial nerve structural organization	Sema3a	IMP		Mouse	MGI:MGI:3822054|PMID:18804103
Biological Process	GO:1903375	facioacoustic ganglion development	Sema3a	IMP		Mouse	MGI:MGI:3788968|PMID:18356247
Biological Process	GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus	Sema3a	IMP		Mouse	MGI:MGI:4850173|PMID:21059704
Biological Process	GO:0099558	maintenance of synapse structure	Sema3a	IMP		Mouse	PMID:24831527
Biological Process	GO:0099558	maintenance of synapse structure	Sema3a	IDA		Mouse	PMID:24831527
Biological Process	GO:0001763	morphogenesis of a branching structure	sema3ab	IMP		Zfish	PMID:15239959
Biological Process	GO:0008045	motor neuron axon guidance	Sema3a	IMP		Mouse	MGI:MGI:3822054|PMID:18804103
Biological Process	GO:0008045	motor neuron axon guidance	sema3aa	IGI	ZFIN:ZDB-MRPHLNO-051129-1,ZFIN:ZDB-MRPHLNO-070613-2	Zfish	PMID:17475806
Biological Process	GO:0008045	motor neuron axon guidance	sema3aa	IGI	ZFIN:ZDB-MRPHLNO-050906-3,ZFIN:ZDB-MRPHLNO-051129-1	Zfish	PMID:16110501
Biological Process	GO:0008045	motor neuron axon guidance	sema3aa	IMP	ZFIN:ZDB-MRPHLNO-050513-3	Zfish	PMID:17699608
Biological Process	GO:0008045	motor neuron axon guidance	sema3aa	IMP	ZFIN:ZDB-MRPHLNO-060323-1	Zfish	PMID:16452100
Biological Process	GO:0008045	motor neuron axon guidance	sema3ab	IGI	ZFIN:ZDB-MRPHLNO-050513-4,ZFIN:ZDB-MRPHLNO-050906-3	Zfish	PMID:16110501
Biological Process	GO:0008045	motor neuron axon guidance	sema3ab	IGI	ZFIN:ZDB-MRPHLNO-050513-4,ZFIN:ZDB-MRPHLNO-070613-2	Zfish	PMID:17475806
Biological Process	GO:0050919	negative chemotaxis	Sema3a	IGI	MGI:MGI:107683	Mouse	PMID:11683995
Biological Process	GO:0030517	negative regulation of axon extension	Sema3a	IDA		Mouse	PMID:12852851
Biological Process	GO:0030517	negative regulation of axon extension	Sema3a	IGI	MGI:MGI:106206	Mouse	PMID:12852851
Biological Process	GO:0030517	negative regulation of axon extension	Sema3a	IDA		Rat	PMID:12077190|RGD:628318
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	Sema3a	IDA		Mouse	PMID:9753685
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	Sema3a	IGI	MGI:MGI:96721	Mouse	PMID:18550718
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	Sema3a	IDA		Mouse	PMID:7748561
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	Sema3a	IGI	MGI:MGI:104518	Mouse	PMID:18550718
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	Sema3a	IGI	MGI:MGI:107683	Mouse	PMID:11683995
Biological Process	GO:0010633	negative regulation of epithelial cell migration	Sema3a	IDA		Mouse	PMID:17626059
Biological Process	GO:0010977	negative regulation of neuron projection development	SEMA3A	IMP		Human	PMID:21593320
Biological Process	GO:0021675	nerve development	Sema3a	IMP		Mouse	MGI:MGI:5437554|PMID:22790009
Biological Process	GO:0007399	nervous system development	Sema3a	IGI	MGI:MGI:2179061	Mouse	PMID:12591607
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	Sema3a	IMP		Mouse	MGI:MGI:3788968|PMID:18356247
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	Sema3a	IMP		Mouse	MGI:MGI:3848580|PMID:19386662
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	Sema3a	IMP		Mouse	MGI:MGI:5567908|PMID:19325129
Biological Process	GO:1903045	neural crest cell migration involved in sympathetic nervous system development	Sema3a	IMP		Mouse	MGI:MGI:5567908|PMID:19325129
Biological Process	GO:0001764	neuron migration	Sema3a	IMP		Mouse	MGI:MGI:4850173|PMID:21059704
Biological Process	GO:0001764	neuron migration	Sema3a	IMP		Mouse	MGI:MGI:5437554|PMID:22790009
Biological Process	GO:0021772	olfactory bulb development	SEMA3A	IMP		Human	PMID:22416012
Biological Process	GO:2000020	positive regulation of male gonad development	Sema3a	IMP		Mouse	MGI:MGI:5437554|PMID:22790009
Biological Process	GO:2001224	positive regulation of neuron migration	Sema3a	IGI	UniProtKB:Q00731-2	Mouse	MGI:MGI:5287519|PMID:21828096
Biological Process	GO:0048841	regulation of axon extension involved in axon guidance	SEMA3A	IDA		Human	PMID:18053124
Biological Process	GO:0048841	regulation of axon extension involved in axon guidance	Sema3a	IDA		Mouse	MGI:MGI:4441128|PMID:15155748
Biological Process	GO:0002027	regulation of heart rate	Sema3a	IMP	MGI:MGI:2158944	Mouse	PMID:17417650
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	Sema3a	IGI	MGI:MGI:2179061	Mouse	PMID:12591607
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	Sema3a	IGI	MGI:MGI:106206	Mouse	PMID:12591607
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	Sema3a	IMP		Mouse	MGI:MGI:3822054|PMID:18804103
Biological Process	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance	Sema3a	IMP		Mouse	MGI:MGI:5437554|PMID:22790009
Biological Process	GO:0061549	sympathetic ganglion development	Sema3a	IMP		Mouse	MGI:MGI:5437554|PMID:22790009
Biological Process	GO:0097490	sympathetic neuron projection extension	Sema3a	IMP		Mouse	MGI:MGI:5437554|PMID:22790009
Biological Process	GO:0097491	sympathetic neuron projection guidance	Sema3a	IMP		Mouse	MGI:MGI:5437554|PMID:22790009
Biological Process	GO:0008039	synaptic target recognition	Sema3a	IDA		Mouse	PMID:22179111
Biological Process	GO:0008039	synaptic target recognition	Sema3a	IMP		Mouse	PMID:22179111
Biological Process	GO:0061551	trigeminal ganglion development	Sema3a	IMP		Mouse	MGI:MGI:3788968|PMID:18356247
Biological Process	GO:0021637	trigeminal nerve structural organization	Sema3a	IMP		Mouse	MGI:MGI:3822054|PMID:18804103
Biological Process	GO:0001570	vasculogenesis	sema3aa	IMP		Zfish	PMID:12783793
Biological Process	GO:0036486	ventral trunk neural crest cell migration	Sema3a	IMP		Mouse	MGI:MGI:3848580|PMID:19386662

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern