Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SEMA4D
  • Mouse genes Sema4d
  • Rat genes Sema4d
  • Zfish genes sema4d
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sema4d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SEMA4D	IPI	UniProtKB:O43157	Human	PMID:20877282
Molecular Function	GO:0005515	protein binding	Sema4d	IPI	PR:Q52KR2	Mouse	PMID:2917992
Molecular Function	GO:0030215	semaphorin receptor binding	SEMA4D	IPI	UniProtKB:O43157	Human	PMID:15218527
Molecular Function	GO:0030215	semaphorin receptor binding	Sema4d	IPI	UniProtKB:Q8CJH3	Mouse	MGI:MGI:5297297|PMID:22019888
Molecular Function	GO:0038023	signaling receptor activity	SEMA4D	IDA		Human	PMID:15613544
Molecular Function	GO:0005102	signaling receptor binding	SEMA4D	IDA		Human	PMID:11254688
Molecular Function	GO:0005102	signaling receptor binding	SEMA4D	IDA		Human	PMID:20877282
Molecular Function	GO:0005102	signaling receptor binding	Sema4d	IPI	PR:Q8CJH3	Mouse	PMID:15330859
Molecular Function	GO:0005102	signaling receptor binding	Sema4d	IPI	PR:B2RXS4	Mouse	PMID:15330859
Molecular Function	GO:0004888	transmembrane signaling receptor activity	SEMA4D	IMP		Human	PMID:20877282
Cellular Component	GO:0005615	extracellular space	Sema4d	IDA		Mouse	MGI:MGI:5297297|PMID:22019888
Cellular Component	GO:0005886	plasma membrane	SEMA4D	IDA		Human	PMID:8876214
Biological Process	GO:0031103	axon regeneration	sema4d	IMP	ZFIN:ZDB-MRPHLNO-170616-1	Zfish	PMID:28347780
Biological Process	GO:0007409	axonogenesis	Sema4d	IGI	MGI:MGI:97383	Mouse	PMID:15330859
Biological Process	GO:0007409	axonogenesis	Sema4d	IGI	MGI:MGI:2154239	Mouse	PMID:15330859
Biological Process	GO:0007409	axonogenesis	Sema4d	IDA		Mouse	PMID:15330859
Biological Process	GO:0007409	axonogenesis	Sema4d	IGI	MGI:MGI:2154238	Mouse	PMID:15330859
Biological Process	GO:0007409	axonogenesis	Sema4d	IGI	MGI:MGI:97321	Mouse	PMID:15330859
Biological Process	GO:0007420	brain development	sema4d	IMP	ZFIN:ZDB-MRPHLNO-130618-2	Zfish	PMID:23466355
Biological Process	GO:0070486	leukocyte aggregation	SEMA4D	IMP		Human	PMID:8876214
Biological Process	GO:0010693	negative regulation of alkaline phosphatase activity	SEMA4D	IMP		Human	PMID:22019888
Biological Process	GO:0010693	negative regulation of alkaline phosphatase activity	Sema4d	IDA		Mouse	MGI:MGI:5297297|PMID:22019888
Biological Process	GO:0007162	negative regulation of cell adhesion	SEMA4D	IDA		Human	PMID:15218527
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Sema4d	IMP		Mouse	MGI:MGI:5297297|PMID:22019888
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Sema4d	IDA		Mouse	MGI:MGI:5297297|PMID:22019888
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SEMA4D	IMP		Human	PMID:22019888
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sema4d	IDA		Mouse	MGI:MGI:5297297|PMID:22019888
Biological Process	GO:0043931	ossification involved in bone maturation	SEMA4D	IMP		Human	PMID:22019888
Biological Process	GO:0043931	ossification involved in bone maturation	Sema4d	IMP		Mouse	MGI:MGI:5297297|PMID:22019888
Biological Process	GO:0050772	positive regulation of axonogenesis	Sema4d	IDA		Mouse	PMID:15330859
Biological Process	GO:0050772	positive regulation of axonogenesis	Sema4d	IGI	MGI:MGI:2154238	Mouse	PMID:15330859
Biological Process	GO:0050772	positive regulation of axonogenesis	Sema4d	IGI	MGI:MGI:97383	Mouse	PMID:15330859
Biological Process	GO:0050772	positive regulation of axonogenesis	Sema4d	IGI	MGI:MGI:97321	Mouse	PMID:15330859
Biological Process	GO:0050772	positive regulation of axonogenesis	Sema4d	IGI	MGI:MGI:2154239	Mouse	PMID:15330859
Biological Process	GO:0030335	positive regulation of cell migration	SEMA4D	IDA		Human	PMID:16055703
Biological Process	GO:0030335	positive regulation of cell migration	Sema4d	IDA		Mouse	MGI:MGI:5297297|PMID:22019888
Biological Process	GO:0048672	positive regulation of collateral sprouting	SEMA4D	IMP		Human	PMID:19788569
Biological Process	GO:0043547	positive regulation of GTPase activity	SEMA4D	IMP		Human	PMID:19788569
Biological Process	GO:0043547	positive regulation of GTPase activity	Sema4d	IMP		Mouse	MGI:MGI:5297297|PMID:22019888
Biological Process	GO:1905704	positive regulation of inhibitory synapse assembly	Sema4d	IDA		Mouse	MGI:MGI:5498626|PMID:23699507
Biological Process	GO:1905704	positive regulation of inhibitory synapse assembly	Sema4d	IMP		Mouse	MGI:MGI:6269924|PMID:29981480
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Sema4d	IDA		Mouse	MGI:MGI:5297297|PMID:22019888
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	SEMA4D	IMP		Human	PMID:16055703
Biological Process	GO:0001934	positive regulation of protein phosphorylation	SEMA4D	IDA		Human	PMID:16055703
Biological Process	GO:0031344	regulation of cell projection organization	SEMA4D	IMP		Human	PMID:20877282
Biological Process	GO:0008360	regulation of cell shape	SEMA4D	IMP		Human	PMID:20877282
Biological Process	GO:0048814	regulation of dendrite morphogenesis	SEMA4D	IMP		Human	PMID:19788569
Biological Process	GO:0009612	response to mechanical stimulus	sema4d	IDA		Zfish	PMID:23632157
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	SEMA4D	IDA		Human	PMID:15218527
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	SEMA4D	IMP		Human	PMID:19788569
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	SEMA4D	IMP		Human	PMID:20877282
Biological Process	GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis	Sema4d	IMP		Mouse	MGI:MGI:5297297|PMID:22019888

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern