Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SEMA5A
  • Mouse genes Sema5a
  • Rat genes Sema5a
  • Zfish genes sema5a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sema5a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008046	axon guidance receptor activity	Sema5a	IDA		Mouse	PMID:12506007
Molecular Function	GO:0035373	chondroitin sulfate proteoglycan binding	Sema5a	IMP		Rat	PMID:15603739|RGD:8553809
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	Sema5a	IMP		Rat	PMID:15603739|RGD:8553809
Molecular Function	GO:0030215	semaphorin receptor binding	Sema5a	IPI	UniProtKB:Q9ULL4	Mouse	MGI:MGI:5526939|PMID:15218527
Molecular Function	GO:0045545	syndecan binding	Sema5a	IPI	UniProtKB:P33671	Rat	PMID:15603739|RGD:8553809
Cellular Component	GO:0070062	extracellular exosome	SEMA5A	HDA		Human	PMID:23533145
Cellular Component	GO:0016020	membrane	Sema5a	IDA		Mouse	PMID:12506007
Cellular Component	GO:0016020	membrane	Sema5a	IDA		Rat	PMID:15603739|RGD:8553809
Biological Process	GO:0048675	axon extension	Sema5a	IGI	MGI:MGI:107555	Mouse	PMID:21835343
Biological Process	GO:0048675	axon extension	sema5a	IGI	ZFIN:ZDB-MRPHLNO-070613-2,ZFIN:ZDB-MRPHLNO-090811-1	Zfish	PMID:19059233
Biological Process	GO:0048675	axon extension	sema5a	IMP	ZFIN:ZDB-MRPHLNO-090811-1	Zfish	PMID:19059233
Biological Process	GO:0007411	axon guidance	Sema5a	IMP		Mouse	PMID:12506007
Biological Process	GO:0007413	axonal fasciculation	Sema5a	IDA		Rat	PMID:15603739|RGD:8553809
Biological Process	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	Sema5a	IDA		Mouse	MGI:MGI:5526935|PMID:19850054
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Sema5a	IMP	MGI:MGI:3577050	Mouse	PMID:15743826
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Sema5a	IMP	MGI:MGI:3577050	Mouse	PMID:15743826
Biological Process	GO:0060326	cell chemotaxis	Sema5a	IDA		Mouse	MGI:MGI:5526939|PMID:15218527
Biological Process	GO:0050908	detection of light stimulus involved in visual perception	Sema5a	IGI	MGI:MGI:107555	Mouse	PMID:21835343
Biological Process	GO:0021536	diencephalon development	Sema5a	IMP		Rat	PMID:15603739|RGD:8553809
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	Sema5a	IMP		Rat	PMID:15603739|RGD:8553809
Biological Process	GO:0007162	negative regulation of cell adhesion	Sema5a	IDA		Mouse	MGI:MGI:5526939|PMID:15218527
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	Sema5a	IDA		Mouse	MGI:MGI:5526935|PMID:19850054
Biological Process	GO:1990138	neuron projection extension	Sema5a	IGI	MGI:MGI:107683	Mouse	PMID:21835343
Biological Process	GO:1990138	neuron projection extension	Sema5a	IGI	MGI:MGI:107685	Mouse	PMID:21835343
Biological Process	GO:1990138	neuron projection extension	Sema5a	IDA		Mouse	PMID:21835343
Biological Process	GO:0097485	neuron projection guidance	Sema5a	IGI	MGI:MGI:107555	Mouse	PMID:21835343
Biological Process	GO:0050918	positive chemotaxis	Sema5a	IDA		Mouse	MGI:MGI:5526939|PMID:15218527
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	Sema5a	IDA		Mouse	MGI:MGI:5526935|PMID:19850054
Biological Process	GO:0045766	positive regulation of angiogenesis	Sema5a	IDA		Mouse	MGI:MGI:5526935|PMID:19850054
Biological Process	GO:0048842	positive regulation of axon extension involved in axon guidance	Sema5a	IMP		Rat	PMID:15603739|RGD:8553809
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Sema5a	IDA		Mouse	MGI:MGI:5526935|PMID:19850054
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis	Sema5a	IDA		Mouse	MGI:MGI:5526935|PMID:19850054
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Sema5a	IDA		Mouse	MGI:MGI:5526935|PMID:19850054
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Sema5a	IDA		Mouse	MGI:MGI:5526935|PMID:19850054
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	Sema5a	IDA		Mouse	MGI:MGI:5526939|PMID:15218527
Biological Process	GO:1990256	signal clustering	Sema5a	IDA		Mouse	MGI:MGI:5526939|PMID:15218527
Biological Process	GO:1990256	signal clustering	Sema5a	IMP		Rat	PMID:15603739|RGD:8553809

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern