Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SEMA6A
  • Mouse genes Sema6a
  • Rat genes Sema6a
  • Zfish genes sema6a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sema6a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Sema6a	IPI	UniProtKB:O35464-1	Mouse	MGI:MGI:5306550|PMID:20877282
Molecular Function	GO:0042802	identical protein binding	Sema6a	IPI	UniProtKB:O35464-1	Mouse	MGI:MGI:5306549|PMID:20881961
Molecular Function	GO:0005515	protein binding	SEMA6A	IPI	UniProtKB:Q9UI08	Human	PMID:10993894
Molecular Function	GO:0005515	protein binding	SEMA6A	IPI	UniProtKB:Q46342:PRO_0000451198	Human	PMID:32302524
Molecular Function	GO:0005515	protein binding	Sema6a	IPI	UniProtKB:Q80UG2	Mouse	MGI:MGI:4821874|PMID:20606624
Molecular Function	GO:0005515	protein binding	Sema6a	IPI	UniProtKB:P70429	Mouse	MGI:MGI:1928176|PMID:10993894
Molecular Function	GO:0005515	protein binding	Sema6a	IPI	UniProtKB:P70207	Mouse	MGI:MGI:5306550|PMID:20877282
Molecular Function	GO:0005515	protein binding	Sema6a	IPI	UniProtKB:P70207	Mouse	MGI:MGI:5306549|PMID:20881961
Molecular Function	GO:0030215	semaphorin receptor binding	Sema6a	IGI	MGI:MGI:107684	Mouse	PMID:18327254
Molecular Function	GO:0030215	semaphorin receptor binding	Sema6a	IPI	PR:P70207	Mouse	PMID:18327254
Molecular Function	GO:0030215	semaphorin receptor binding	Sema6a	IPI	PR:Q80UG2	Mouse	PMID:15814794
Molecular Function	GO:0030215	semaphorin receptor binding	Sema6a	IGI	MGI:MGI:1203727	Mouse	PMID:18327254
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Sema6a	IMP		Mouse	MGI:MGI:5306550|PMID:20877282
Cellular Component	GO:0005886	plasma membrane	Sema6a	IDA		Mouse	MGI:MGI:5306550|PMID:20877282
Biological Process	GO:0007411	axon guidance	Sema6a	IMP		Mouse	MGI:MGI:3607683|PMID:16205717
Biological Process	GO:0007166	cell surface receptor signaling pathway	Sema6a	IDA		Mouse	PMID:18327254
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	SEMA6A	IDA		Human	PMID:21536891
Biological Process	GO:0051642	centrosome localization	Sema6a	IMP	MGI:MGI:2156202	Mouse	PMID:18327254
Biological Process	GO:0016525	negative regulation of angiogenesis	SEMA6A	IGI	RNAcentral:URS000059311D_9606	Human	PMID:24177325
Biological Process	GO:0106089	negative regulation of cell adhesion involved in sprouting angiogenesis	SEMA6A	IGI	RNAcentral:URS000059311D_9606	Human	PMID:24177325
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	SEMA6A	IDA		Human	PMID:21536891
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	SEMA6A	IDA		Human	PMID:22184411
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	SEMA6A	IDA		Human	PMID:21536891
Biological Process	GO:0001764	neuron migration	Sema6a	IMP		Mouse	MGI:MGI:3607683|PMID:16205717
Biological Process	GO:0003403	optic vesicle formation	sema6a	IMP	ZFIN:ZDB-MRPHLNO-140821-3	Zfish	PMID:24917502
Biological Process	GO:0003403	optic vesicle formation	sema6a	IGI	ZFIN:ZDB-MRPHLNO-140821-3,ZFIN:ZDB-MRPHLNO-150427-2	Zfish	PMID:24917502
Biological Process	GO:2001224	positive regulation of neuron migration	Sema6a	IMP		Mouse	MGI:MGI:5306550|PMID:20877282
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	Sema6a	IMP		Mouse	MGI:MGI:5306550|PMID:20877282

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern