Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SERPINA1
  • Mouse genes Serpina1b
  • Rat genes Serpina1
  • Zfish genes serpina1,serpina1l,serpina7,si:ch211-186e20.7,zgc:113828,zgc:174259,zgc:174260
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Serpina1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004866	endopeptidase inhibitor activity	Serpina1	IDA		Rat	PMID:11917148|RGD:1643166
Molecular Function	GO:0042802	identical protein binding	SERPINA1	IPI	UniProtKB:P01009	Human	PMID:11057674
Molecular Function	GO:0042802	identical protein binding	SERPINA1	IPI	UniProtKB:P01009	Human	PMID:18923394
Molecular Function	GO:0042802	identical protein binding	SERPINA1	IPI	UniProtKB:P01009	Human	PMID:21909074
Molecular Function	GO:0042802	identical protein binding	SERPINA1	IPI	UniProtKB:P01009	Human	PMID:22405009
Molecular Function	GO:0002020	protease binding	SERPINA1	IPI	UniProtKB:Q8BIK6	Human	PMID:15853774
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P00760	Human	PMID:11057674
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P00760	Human	PMID:12860985
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:Q92876	Human	PMID:12878203
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P71213	Human	PMID:15271889
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P14625	Human	PMID:15845869
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P07478	Human	PMID:16192646
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P00760	Human	PMID:16321984
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P00772	Human	PMID:16321984
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P43307	Human	PMID:17380188
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:Q12907	Human	PMID:20477988
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P00760	Human	PMID:22115549
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P27824	Human	PMID:23826168
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P30101	Human	PMID:23826168
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P49257	Human	PMID:31142615
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:Q9Y282	Human	PMID:31142615
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:P08217	Human	PMID:31358993
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:Q8N7X4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SERPINA1	IPI	UniProtKB:O15393	Human	PMID:33741941
Molecular Function	GO:0005515	protein binding	Serpina1b	IPI	UniProtKB:P08246	Mouse	PMID:11961105
Molecular Function	GO:0005515	protein binding	Serpina1	IPI	RGD:1604066	Rat	PMID:11917148|RGD:1643166
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINA1	IDA		Human	PMID:15795238
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Serpina1b	IMP	MGI:MGI:3512411	Mouse	PMID:15516792
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Serpina1	IDA		Rat	PMID:19240864|RGD:7411612
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINA1	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINA1	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINA1	HDA		Human	PMID:28675934
Cellular Component	GO:0005783	endoplasmic reticulum	SERPINA1	IDA		Human	PMID:20477988
Cellular Component	GO:0005783	endoplasmic reticulum	SERPINA1	IDA		Human	PMID:23826168
Cellular Component	GO:0070062	extracellular exosome	SERPINA1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SERPINA1	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	Serpina1b	IDA		Mouse	PMID:11961105
Cellular Component	GO:0005615	extracellular space	SERPINA1	IMP		Human	PMID:16192646
Cellular Component	GO:0005615	extracellular space	SERPINA1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	SERPINA1	HDA		Human	PMID:23580065
Cellular Component	GO:0005615	extracellular space	SERPINA1	IDA		Human	PMID:25645918
Cellular Component	GO:0005615	extracellular space	SERPINA1	IDA		Human	PMID:6980881
Cellular Component	GO:0005615	extracellular space	Serpina1	IDA		Rat	PMID:17634200|RGD:1643156
Cellular Component	GO:0005794	Golgi apparatus	SERPINA1	IDA		Human	PMID:20477988
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SERPINA1	IDA		Human	GO_REF:0000052
Biological Process	GO:0001701	in utero embryonic development	Serpina1b	IMP	MGI:MGI:3512411	Mouse	PMID:15516792
Biological Process	GO:0006954	inflammatory response	Serpina1	IEP		Rat	PMID:20118217|RGD:5131869
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	Serpina1	IDA		Rat	PMID:19240864|RGD:7411612
Biological Process	GO:0006487	protein N-linked glycosylation	Serpina1b	IDA		Mouse	PMID:11961105
Biological Process	GO:0046687	response to chromate	Serpina1	IDA		Rat	PMID:12122574|RGD:1643165
Biological Process	GO:0034097	response to cytokine	Serpina1b	IDA		Mouse	PMID:15795238
Biological Process	GO:0034097	response to cytokine	Serpina1	IEP		Rat	PMID:9533938|RGD:2300111
Biological Process	GO:0032355	response to estradiol	Serpina1	IEP		Rat	PMID:1466268|RGD:1643153
Biological Process	GO:0001666	response to hypoxia	Serpina1	IEP		Rat	PMID:12121987|RGD:1643146
Biological Process	GO:0010035	response to inorganic substance	Serpina1	IEP		Rat	PMID:9950889|RGD:1643169
Biological Process	GO:0010288	response to lead ion	Serpina1	IDA		Rat	PMID:11392791|RGD:1643167
Biological Process	GO:0032496	response to lipopolysaccharide	Serpina1	IEP		Rat	PMID:1466268|RGD:1643153
Biological Process	GO:0033986	response to methanol	Serpina1	IDA		Rat	PMID:10478824|RGD:2292013
Biological Process	GO:0014070	response to organic cyclic compound	Serpina1	IEP		Rat	PMID:8502664|RGD:1643152
Biological Process	GO:0043434	response to peptide hormone	Serpina1b	IDA		Mouse	PMID:15795238
Biological Process	GO:0034014	response to triglyceride	Serpina1	IEP		Rat	PMID:10362649|RGD:2292229

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern