Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SERPINB1
  • Mouse genes Serpinb1a
  • Rat genes Serpinb1a
  • Zfish genes serpinb1,serpinb1l2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Serpinb1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030414	peptidase inhibitor activity	SERPINB1	IDA		Human	PMID:26701651
Molecular Function	GO:0005515	protein binding	SERPINB1	IPI	UniProtKB:P24158	Human	PMID:30692621
Molecular Function	GO:0005515	protein binding	SERPINB1	IPI	UniProtKB:P29466	Human	PMID:30692621
Molecular Function	GO:0005515	protein binding	SERPINB1	IPI	UniProtKB:P49662	Human	PMID:30692621
Molecular Function	GO:0005515	protein binding	SERPINB1	IPI	UniProtKB:P51878	Human	PMID:30692621
Molecular Function	GO:0005515	protein binding	Serpinb1a	IPI	UniProtKB:P29452|UniProtKB:P70343	Mouse	MGI:MGI:6294164|PMID:30692621
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINB1	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINB1	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Serpinb1a	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	SERPINB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	SERPINB1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SERPINB1	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	SERPINB1	IDA		Human	PMID:26701651
Cellular Component	GO:0005576	extracellular region	SERPINB1	HDA		Human	PMID:27068509
Cellular Component	GO:0005576	extracellular region	Serpinb1a	IDA		Mouse	MGI:MGI:5780008|PMID:26701651
Cellular Component	GO:0005615	extracellular space	SERPINB1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	SERPINB1	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	SERPINB1	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	SERPINB1	HDA		Human	PMID:23580065
Cellular Component	GO:0016020	membrane	SERPINB1	HDA		Human	PMID:19946888
Biological Process	GO:0019725	cellular homeostasis	Serpinb1a	IDA		Mouse	MGI:MGI:6294188|PMID:21683252
Biological Process	GO:0006954	inflammatory response	Serpinb1a	IDA		Mouse	MGI:MGI:6294188|PMID:21683252
Biological Process	GO:0010951	negative regulation of endopeptidase activity	SERPINB1	IDA		Human	PMID:30692621
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	SERPINB1	IMP		Human	PMID:30692621
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Serpinb1a	IMP		Mouse	MGI:MGI:6294164|PMID:30692621
Biological Process	GO:0045088	regulation of innate immune response	Serpinb1a	IDA		Mouse	MGI:MGI:3760197|PMID:17664292
Biological Process	GO:0042176	regulation of protein catabolic process	Serpinb1a	IPI	UniProtKB:P08254	Mouse	PMID:12189154
Biological Process	GO:0042176	regulation of protein catabolic process	Serpinb1a	IPI	UniProtKB:P00772	Mouse	PMID:12189154
Biological Process	GO:0042176	regulation of protein catabolic process	Serpinb1a	IPI	UniProtKB:P08311	Mouse	PMID:12189154
Biological Process	GO:0042176	regulation of protein catabolic process	Serpinb1a	IPI	UniProtKB:P08246	Mouse	PMID:12189154
Biological Process	GO:0044342	type B pancreatic cell proliferation	SERPINB1	IDA		Human	PMID:26701651
Biological Process	GO:0044342	type B pancreatic cell proliferation	Serpinb1a	IDA		Mouse	MGI:MGI:5780008|PMID:26701651

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern