Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SERPINB3,SERPINB4
  • Mouse genes Serpinb3c
  • Rat genes Serpinb3,Serpinb3a
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Serpinb3c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	SERPINB3	IMP		Human	PMID:21383048
Molecular Function	GO:0019899	enzyme binding	SERPINB4	IPI	UniProtKB:Q96EB6	Human	PMID:23382074
Molecular Function	GO:0002020	protease binding	SERPINB3	IPI	UniProtKB:P00784	Human	PMID:21383048
Molecular Function	GO:0002020	protease binding	SERPINB3	IPI	UniProtKB:P07711	Human	PMID:21383048
Molecular Function	GO:0002020	protease binding	SERPINB4	IPI	UniProtKB:P51124	Human	PMID:21857942
Molecular Function	GO:0005515	protein binding	Serpinb3c	IPI	PR:Q8R1Y2	Mouse	PMID:11591653
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINB4	IDA		Human	PMID:21857942
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Serpinb3c	IDA		Mouse	PMID:9828132
Molecular Function	GO:0001618	virus receptor activity	SERPINB3	IDA		Human	PMID:12975381
Cellular Component	GO:0005737	cytoplasm	SERPINB3	IDA		Human	PMID:20527027
Cellular Component	GO:0031410	cytoplasmic vesicle	SERPINB3	IDA		Human	PMID:21383048
Cellular Component	GO:0005829	cytosol	SERPINB3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	SERPINB4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	SERPINB3	HDA		Human	PMID:19056867
Cellular Component	GO:0005634	nucleus	SERPINB3	IDA		Human	PMID:20527027
Cellular Component	GO:0005634	nucleus	SERPINB3	IDA		Human	PMID:21383048
Cellular Component	GO:0005634	nucleus	SERPINB3	HDA		Human	PMID:21630459
Cellular Component	GO:0005886	plasma membrane	SERPINB3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SERPINB4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031982	vesicle	SERPINB3	HDA		Human	PMID:19190083
Biological Process	GO:0035425	autocrine signaling	SERPINB3	IMP		Human	PMID:20527027
Biological Process	GO:0043086	negative regulation of catalytic activity	SERPINB3	IDA		Human	PMID:10956412
Biological Process	GO:0010951	negative regulation of endopeptidase activity	SERPINB3	IMP		Human	PMID:21383048
Biological Process	GO:0043508	negative regulation of JUN kinase activity	SERPINB3	IMP		Human	PMID:21383048
Biological Process	GO:0010466	negative regulation of peptidase activity	SERPINB3	IDA		Human	PMID:12949073
Biological Process	GO:0010466	negative regulation of peptidase activity	SERPINB4	IDA		Human	PMID:12949073
Biological Process	GO:0045861	negative regulation of proteolysis	SERPINB3	IDA		Human	PMID:12975381
Biological Process	GO:0038001	paracrine signaling	SERPINB3	IMP		Human	PMID:20527027
Biological Process	GO:0030335	positive regulation of cell migration	SERPINB3	IMP		Human	PMID:20527027
Biological Process	GO:0008284	positive regulation of cell population proliferation	SERPINB3	IMP		Human	PMID:20527027
Biological Process	GO:0010950	positive regulation of endopeptidase activity	SERPINB3	IDA		Human	PMID:20527027
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	SERPINB3	IMP		Human	PMID:20527027
Biological Process	GO:0042270	protection from natural killer cell mediated cytotoxicity	SERPINB4	IMP		Human	PMID:21857942

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern