Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SERPINE2
  • Mouse genes Serpine2
  • Rat genes Serpine2
  • Zfish genes serpine2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Serpine2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005539	glycosaminoglycan binding	SERPINE2	IDA		Human	PMID:19855083
Molecular Function	GO:0008201	heparin binding	SERPINE2	IDA		Human	PMID:1939253
Molecular Function	GO:0008201	heparin binding	SERPINE2	IDA		Human	PMID:3997857
Molecular Function	GO:0008201	heparin binding	Serpine2	IDA		Rat	PMID:19167525|RGD:2317918
Molecular Function	GO:0005515	protein binding	SERPINE2	IPI	UniProtKB:P05981	Human	PMID:19911255
Molecular Function	GO:0005515	protein binding	SERPINE2	IPI	UniProtKB:Q16651	Human	PMID:19911255
Molecular Function	GO:0005515	protein binding	SERPINE2	IPI	UniProtKB:Q8IZU0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SERPINE2	IPI	UniProtKB:P00734	Human	PMID:3279057
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINE2	IDA		Human	PMID:19249338
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINE2	IDA		Human	PMID:19855083
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINE2	IMP		Human	PMID:19855083
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SERPINE2	IDA		Human	PMID:3997857
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Serpine2	IMP		Mouse	MGI:MGI:4418017|PMID:19855083
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:11248026
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	Serpine2	IDA		Rat	PMID:19167525|RGD:2317918
Molecular Function	GO:0005102	signaling receptor binding	SERPINE2	IPI	UniProtKB:P07204	Human	PMID:17379830
Molecular Function	GO:0005102	signaling receptor binding	Serpine2	IGI	MGI:MGI:96828	Mouse	PMID:17409116
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINE2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SERPINE2	IDA		Human	PMID:3279057
Cellular Component	GO:0005829	cytosol	SERPINE2	IDA		Human	PMID:19855083
Cellular Component	GO:0005576	extracellular region	SERPINE2	IDA		Human	PMID:19855083
Cellular Component	GO:0005576	extracellular region	SERPINE2	IDA		Human	PMID:3997857
Cellular Component	GO:0005576	extracellular region	Serpine2	IDA		Mouse	MGI:MGI:4458005|PMID:2037625
Cellular Component	GO:0005615	extracellular space	Serpine2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Serpine2	IDA		Rat	PMID:16192390|RGD:2317929
Cellular Component	GO:1903561	extracellular vesicle	SERPINE2	HDA		Human	PMID:24769233
Cellular Component	GO:0016020	membrane	Serpine2	IDA		Rat	PMID:15281096|RGD:2317931
Cellular Component	GO:0031594	neuromuscular junction	Serpine2	IDA		Mouse	MGI:MGI:4458005|PMID:2037625
Cellular Component	GO:0043025	neuronal cell body	Serpine2	IDA		Rat	PMID:9751132|RGD:2317934
Cellular Component	GO:0031091	platelet alpha granule	SERPINE2	IDA		Human	PMID:19855083
Cellular Component	GO:0031091	platelet alpha granule	SERPINE2	IMP		Human	PMID:19855083
Biological Process	GO:0007596	blood coagulation	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:19855083
Biological Process	GO:0021683	cerebellar granular layer morphogenesis	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:17409116
Biological Process	GO:0061110	dense core granule biogenesis	Serpine2	IDA		Rat	PMID:16319172|RGD:2317924
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:15509762
Biological Process	GO:0007566	embryo implantation	Serpine2	IEP		Rat	PMID:11457471|RGD:2317933
Biological Process	GO:0060384	innervation	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:17409231
Biological Process	GO:0060291	long-term synaptic potentiation	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:9169529
Biological Process	GO:0042628	mating plug formation	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:11248026
Biological Process	GO:0030195	negative regulation of blood coagulation	SERPINE2	IDA		Human	PMID:17379830
Biological Process	GO:0030195	negative regulation of blood coagulation	Serpine2	IDA		Rat	PMID:17379830|RGD:8553298
Biological Process	GO:0030308	negative regulation of cell growth	Serpine2	IGI	MGI:MGI:88380	Mouse	PMID:18398001
Biological Process	GO:0008285	negative regulation of cell population proliferation	Serpine2	IGI	MGI:MGI:88380	Mouse	PMID:18398001
Biological Process	GO:0010466	negative regulation of peptidase activity	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:18398001
Biological Process	GO:0010466	negative regulation of peptidase activity	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:15509762
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	Serpine2	IGI	MGI:MGI:88380	Mouse	PMID:18398001
Biological Process	GO:0010757	negative regulation of plasminogen activation	SERPINE2	IMP		Human	PMID:19855083
Biological Process	GO:0010757	negative regulation of plasminogen activation	Serpine2	IMP		Mouse	MGI:MGI:4418017|PMID:19855083
Biological Process	GO:0010544	negative regulation of platelet activation	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:19855083
Biological Process	GO:0090331	negative regulation of platelet aggregation	Serpine2	IMP		Mouse	MGI:MGI:4418017|PMID:19855083
Biological Process	GO:0042177	negative regulation of protein catabolic process	Serpine2	IMP		Mouse	PMID:16319172
Biological Process	GO:0042177	negative regulation of protein catabolic process	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:15509762
Biological Process	GO:0045861	negative regulation of proteolysis	SERPINE2	IDA		Human	PMID:17379830
Biological Process	GO:0045861	negative regulation of proteolysis	SERPINE2	IDA		Human	PMID:3997857
Biological Process	GO:0045861	negative regulation of proteolysis	Serpine2	IDA		Rat	PMID:17379830|RGD:8553298
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Serpine2	IGI	MGI:MGI:98297	Mouse	PMID:17409116
Biological Process	GO:0010766	negative regulation of sodium ion transport	Serpine2	IGI	MGI:MGI:101782	Mouse	PMID:16941024
Biological Process	GO:0010766	negative regulation of sodium ion transport	Serpine2	IGI	MGI:MGI:104696	Mouse	PMID:16941024
Biological Process	GO:0010766	negative regulation of sodium ion transport	Serpine2	IMP		Mouse	PMID:16941024
Biological Process	GO:0010766	negative regulation of sodium ion transport	Serpine2	IGI	MGI:MGI:104695	Mouse	PMID:16941024
Biological Process	GO:0030168	platelet activation	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:19855083
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	SERPINE2	IDA		Human	PMID:1691280
Biological Process	GO:0010976	positive regulation of neuron projection development	Serpine2	IDA		Rat	PMID:19167525|RGD:2317918
Biological Process	GO:0030163	protein catabolic process	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:15509762
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:15509762
Biological Process	GO:0048505	regulation of timing of cell differentiation	Serpine2	IMP		Mouse	PMID:17409116
Biological Process	GO:0009314	response to radiation	Serpine2	IEP		Rat	PMID:8373421|RGD:2317935
Biological Process	GO:0009611	response to wounding	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:17409231
Biological Process	GO:0032940	secretion by cell	Serpine2	IMP		Mouse	PMID:16319172
Biological Process	GO:0033363	secretory granule organization	Serpine2	IMP		Mouse	PMID:16319172
Biological Process	GO:0033363	secretory granule organization	Serpine2	IDA		Rat	PMID:16319172|RGD:2317924
Biological Process	GO:0061108	seminal vesicle epithelium development	Serpine2	IMP	MGI:MGI:2387774	Mouse	PMID:11248026

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern