Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sesn2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SESN2
- Mouse genes Sesn2
- Rat genes Sesn2
- Zfish genes sesn2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sesn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005092	GDP-dissociation inhibitor activity	Sesn2	IDA		Mouse	MGI:MGI:5604284\|PMID:25259925
Molecular Function	GO:0070728	leucine binding	SESN2	IDA		Human	PMID:26449471
Molecular Function	GO:0070728	leucine binding	SESN2	IDA		Human	PMID:26586190
Molecular Function	GO:0070728	leucine binding	SESN2	IDA		Human	PMID:35114100
Molecular Function	GO:0004601	peroxidase activity	SESN2	IDA		Human	PMID:26612684
Molecular Function	GO:0042731	PH domain binding	Sesn2	IPI	PR:000050596	Mouse	PMID:31915252
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q06830	Human	PMID:15105503
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:P49815	Human	PMID:18692468
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q92574	Human	PMID:18692468
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:P62877	Human	PMID:23274085
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:P62878	Human	PMID:23274085
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q13501	Human	PMID:23274085
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q14145	Human	PMID:23274085
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:O70405	Human	PMID:25040165
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q13501	Human	PMID:25040165
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q96S15	Human	PMID:25263562
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q9NXC5	Human	PMID:25263562
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q96S15	Human	PMID:26449471
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q96S15	Human	PMID:26586190
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q9NXC5	Human	PMID:26586190
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q6PJI9	Human	PMID:26972053
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q96S15	Human	PMID:28199315
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:Q9NXC5	Human	PMID:28199315
Molecular Function	GO:0005515	protein binding	SESN2	IPI	UniProtKB:P62877	Human	PMID:29294217
Molecular Function	GO:0005515	protein binding	Sesn2	IPI	UniProtKB:Q61037\|UniProtKB:Q9EP53	Mouse	MGI:MGI:3808916\|PMID:18692468
Molecular Function	GO:0005515	protein binding	Sesn2	IPI	UniProtKB:Q5VZM2\|UniProtKB:Q7L523\|UniProtKB:Q9HB90\|UniProtKB:Q9NQL2	Mouse	MGI:MGI:5604284\|PMID:25259925
Molecular Function	GO:0140311	protein sequestering activity	SESN2	IDA		Human	PMID:26586190
Molecular Function	GO:0140311	protein sequestering activity	SESN2	IDA		Human	PMID:35114100
Molecular Function	GO:0044877	protein-containing complex binding	SESN2	IPI	GO:0061700	Human	PMID:25263562
Molecular Function	GO:0044877	protein-containing complex binding	SESN2	IPI	GO:0061700	Human	PMID:25457612
Molecular Function	GO:0044877	protein-containing complex binding	SESN2	IPI	GO:0061700	Human	PMID:26586190
Molecular Function	GO:0044877	protein-containing complex binding	SESN2	IPI	GO:0061700	Human	PMID:26612684
Molecular Function	GO:0032542	sulfiredoxin activity	SESN2	IDA		Human	PMID:15105503
Cellular Component	GO:1990316	Atg1/ULK1 kinase complex	SESN2	IPI	GO:1990316	Human	PMID:25040165
Cellular Component	GO:0005737	cytoplasm	SESN2	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	SESN2	IDA		Human	PMID:15105503
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	Sesn2	IDA		Mouse	MGI:MGI:3808916\|PMID:18692468
Cellular Component	GO:0031932	TORC2 complex	Sesn2	IDA		Mouse	MGI:MGI:5779633\|PMID:25377878
Biological Process	GO:0032147	activation of protein kinase activity	Sesn2	IDA		Mouse	PMID:31915252
Biological Process	GO:0098869	cellular oxidant detoxification	SESN2	IMP		Human	PMID:15105503
Biological Process	GO:0098869	cellular oxidant detoxification	SESN2	IDA		Human	PMID:26612684
Biological Process	GO:0034198	cellular response to amino acid starvation	SESN2	IMP		Human	PMID:25263562
Biological Process	GO:0071230	cellular response to amino acid stimulus	SESN2	IMP		Human	PMID:25457612
Biological Process	GO:0071230	cellular response to amino acid stimulus	Sesn2	IMP		Mouse	MGI:MGI:5604284\|PMID:25259925
Biological Process	GO:0042149	cellular response to glucose starvation	SESN2	IMP		Human	PMID:25263562
Biological Process	GO:0071233	cellular response to leucine	SESN2	IDA		Human	PMID:26449471
Biological Process	GO:0071233	cellular response to leucine	SESN2	IMP		Human	PMID:26586190
Biological Process	GO:1990253	cellular response to leucine starvation	SESN2	IMP		Human	PMID:26449471
Biological Process	GO:1990253	cellular response to leucine starvation	SESN2	IDA		Human	PMID:35114100
Biological Process	GO:0034599	cellular response to oxidative stress	Sesn2	IMP		Mouse	MGI:MGI:5476413\|PMID:23274085
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	SESN2	IMP		Human	PMID:18692468
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	Sesn2	IMP		Mouse	MGI:MGI:3808916\|PMID:18692468
Biological Process	GO:0006635	fatty acid beta-oxidation	Sesn2	IGI	MGI:MGI:104663	Mouse	PMID:22958918
Biological Process	GO:0042593	glucose homeostasis	Sesn2	IGI	MGI:MGI:104663	Mouse	PMID:22958918
Biological Process	GO:0046323	glucose import	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918
Biological Process	GO:0032042	mitochondrial DNA metabolic process	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918
Biological Process	GO:0007005	mitochondrion organization	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918
Biological Process	GO:0030308	negative regulation of cell growth	Sesn2	IDA		Mouse	MGI:MGI:5784981\|PMID:20203043
Biological Process	GO:1904262	negative regulation of TORC1 signaling	SESN2	IMP		Human	PMID:18692468
Biological Process	GO:1904262	negative regulation of TORC1 signaling	SESN2	IMP		Human	PMID:24947615
Biological Process	GO:1904262	negative regulation of TORC1 signaling	SESN2	IMP		Human	PMID:25263562
Biological Process	GO:1904262	negative regulation of TORC1 signaling	SESN2	IMP		Human	PMID:25457612
Biological Process	GO:1904262	negative regulation of TORC1 signaling	SESN2	IMP		Human	PMID:26449471
Biological Process	GO:1904262	negative regulation of TORC1 signaling	SESN2	IMP		Human	PMID:26586190
Biological Process	GO:1904262	negative regulation of TORC1 signaling	SESN2	IMP		Human	PMID:26612684
Biological Process	GO:1904262	negative regulation of TORC1 signaling	SESN2	IDA		Human	PMID:35114100
Biological Process	GO:1904262	negative regulation of TORC1 signaling	Sesn2	IMP		Mouse	MGI:MGI:5604284\|PMID:25259925
Biological Process	GO:1904262	negative regulation of TORC1 signaling	Sesn2	IMP		Mouse	MGI:MGI:5688277\|PMID:24947615
Biological Process	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	SESN2	IMP		Human	PMID:24947615
Biological Process	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	Sesn2	IMP		Mouse	MGI:MGI:5688277\|PMID:24947615
Biological Process	GO:1904504	positive regulation of lipophagy	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918
Biological Process	GO:0016239	positive regulation of macroautophagy	SESN2	IMP		Human	PMID:23274085
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	SESN2	IMP		Human	PMID:23274085
Biological Process	GO:1904263	positive regulation of TORC1 signaling	SESN2	IDA		Human	PMID:26449471
Biological Process	GO:1904263	positive regulation of TORC1 signaling	SESN2	IDA		Human	PMID:26586190
Biological Process	GO:0043491	protein kinase B signaling	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918
Biological Process	GO:0072593	reactive oxygen species metabolic process	SESN2	IMP		Human	PMID:15105503
Biological Process	GO:0072593	reactive oxygen species metabolic process	SESN2	IDA		Human	PMID:26612684
Biological Process	GO:2000479	regulation of cAMP-dependent protein kinase activity	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918
Biological Process	GO:0006111	regulation of gluconeogenesis	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918
Biological Process	GO:0001932	regulation of protein phosphorylation	SESN2	IDA		Human	PMID:25040165
Biological Process	GO:0001932	regulation of protein phosphorylation	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918
Biological Process	GO:0009749	response to glucose	Sesn2	IGI	MGI:MGI:1922997	Mouse	PMID:22958918
Biological Process	GO:0009749	response to glucose	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918
Biological Process	GO:0009749	response to glucose	Sesn2	IGI	MGI:MGI:104663	Mouse	PMID:22958918
Biological Process	GO:0032868	response to insulin	Sesn2	IGI	MGI:MGI:104663	Mouse	PMID:22958918
Biological Process	GO:0032868	response to insulin	Sesn2	IGI	MGI:MGI:1922997	Mouse	PMID:22958918
Biological Process	GO:0032868	response to insulin	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918
Biological Process	GO:0070328	triglyceride homeostasis	Sesn2	IMP	MGI:MGI:3587950	Mouse	PMID:22958918

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.