Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sfn

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SFN
- Mouse genes Sfn
- Rat genes Sfn,Sfnl1
- Zfish genes ywhaqa,ywhaqb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sfn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	SFN	HDA		Human	PMID:25468996
Molecular Function	GO:0042802	identical protein binding	SFN	IPI	UniProtKB:P31947	Human	PMID:15778465
Molecular Function	GO:0042802	identical protein binding	SFN	IPI	UniProtKB:P31947	Human	PMID:32296183
Molecular Function	GO:0051219	phosphoprotein binding	Sfn	IPI	UniProtKB:P08152	Mouse	MGI:MGI:3768327\|PMID:17938205
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P06493	Human	PMID:11574543
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q07812	Human	PMID:11574543
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P04049	Human	PMID:11697890
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P00533	Human	PMID:15657067
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P00519	Human	PMID:15696159
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:O60269	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P04049	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P10398	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P15056	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P27448	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P56524	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P61981	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q13470	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q8WUI4	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q96IF1	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q9UJM3	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q9Y2U5	Human	PMID:15778465
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q9UQL6	Human	PMID:15923258
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:O00444	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:O60269	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P27448	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q92934	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q96HA8	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P56524	Human	PMID:16767219
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P00533	Human	PMID:16799092
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q14103-4	Human	PMID:16902409
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q8WUI4	Human	PMID:18339811
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q8NFH8	Human	PMID:18647389
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q9UQC2	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q96PX8	Human	PMID:19640509
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q92934	Human	PMID:20005908
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q92934	Human	PMID:20179209
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P04637	Human	PMID:20206173
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P63104	Human	PMID:20618440
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q8NHY2	Human	PMID:20843328
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P04637	Human	PMID:21625211
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q7L5N1	Human	PMID:21625211
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q8NHY2	Human	PMID:21625211
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q92934	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q9UBF8	Human	PMID:23572552
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P56524	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q8WUI4	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q9UQL6	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P00533	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q5S007	Human	PMID:24510904
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P43355	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P51946	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P98177	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q13064	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q17RB8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q53FD0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q68D86	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q8IZU0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q96QF0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q9NYF3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P04049	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P10398	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q13470	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q9Y2U5	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q5S007	Human	PMID:28202711
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P61981	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P10636-2	Human	PMID:28575131
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q5S007	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P51946	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P04049	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P10398	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P15056	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q92934	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P55771	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q86Z20	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:Q5T1R4	Human	PMID:34341191
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P04049	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	SFN	IPI	UniProtKB:P78559	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Sfn	IPI	UniProtKB:Q9QWL7	Mouse	MGI:MGI:3625597\|PMID:16710422
Molecular Function	GO:0005515	protein binding	Sfn	IDA		Mouse	PMID:18606808
Molecular Function	GO:0019901	protein kinase binding	Sfn	IDA		Mouse	MGI:MGI:1890017\|PMID:10767298
Cellular Component	GO:0005737	cytoplasm	Sfn	IDA		Mouse	MGI:MGI:3625597\|PMID:16710422
Cellular Component	GO:0005829	cytosol	SFN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	SFN	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SFN	HDA		Human	PMID:23533145
Cellular Component	GO:0005634	nucleus	Sfn	IDA		Mouse	MGI:MGI:3625597\|PMID:16710422
Biological Process	GO:0061436	establishment of skin barrier	Sfn	IMP		Mouse	MGI:MGI:5529391\|PMID:24075906
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	SFN	IDA		Human	PMID:11574543
Biological Process	GO:0031424	keratinization	Sfn	IMP	MGI:MGI:1861121	Mouse	PMID:6174530
Biological Process	GO:0003334	keratinocyte development	Sfn	IGI	MGI:MGI:1916323	Mouse	PMID:24075906
Biological Process	GO:0030216	keratinocyte differentiation	Sfn	IMP	MGI:MGI:1861121	Mouse	PMID:16239341
Biological Process	GO:0043616	keratinocyte proliferation	Sfn	IGI	MGI:MGI:1916323	Mouse	PMID:24075906
Biological Process	GO:0043616	keratinocyte proliferation	Sfn	IGI	MGI:MGI:1859211	Mouse	PMID:17041603
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	SFN	IDA		Human	PMID:11574543
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	Sfn	IGI	MGI:MGI:1916323	Mouse	PMID:24075906
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	Sfn	IGI	MGI:MGI:1859211	Mouse	PMID:17041603
Biological Process	GO:2000647	negative regulation of stem cell proliferation	Sfn	IGI	MGI:MGI:1916323	Mouse	PMID:24075906
Biological Process	GO:2000647	negative regulation of stem cell proliferation	Sfn	IGI	MGI:MGI:1859211	Mouse	PMID:17041603
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sfn	IDA		Mouse	PMID:18606808
Biological Process	GO:0030307	positive regulation of cell growth	Sfn	IDA		Mouse	MGI:MGI:3625597\|PMID:16710422
Biological Process	GO:0045606	positive regulation of epidermal cell differentiation	Sfn	IMP		Mouse	MGI:MGI:5529391\|PMID:24075906
Biological Process	GO:0046827	positive regulation of protein export from nucleus	Sfn	IDA		Mouse	MGI:MGI:3768327\|PMID:17938205
Biological Process	GO:0006611	protein export from nucleus	Sfn	IDA		Mouse	PMID:18606808
Biological Process	GO:0010737	protein kinase A signaling	Sfn	IDA		Mouse	PMID:18606808
Biological Process	GO:0051726	regulation of cell cycle	Sfn	IDA		Mouse	PMID:10767298
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	Sfn	IDA		Mouse	PMID:10767298
Biological Process	GO:0010482	regulation of epidermal cell division	Sfn	IMP		Mouse	MGI:MGI:5529391\|PMID:24075906
Biological Process	GO:0001836	release of cytochrome c from mitochondria	SFN	IDA		Human	PMID:11574543
Biological Process	GO:0043588	skin development	Sfn	IMP	MGI:MGI:1861121	Mouse	PMID:16239341
Biological Process	GO:0043588	skin development	Sfn	IGI	MGI:MGI:1859211	Mouse	PMID:17041603
Biological Process	GO:0072089	stem cell proliferation	Sfn	IGI	MGI:MGI:1859211	Mouse	PMID:17041603
Biological Process	GO:0072089	stem cell proliferation	Sfn	IGI	MGI:MGI:1916323	Mouse	PMID:24075906

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.