Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SFPQ
  • Mouse genes Sfpq
  • Rat genes Sfpq
  • Zfish genes sfpq
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sfpq

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Sfpq	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Molecular Function	GO:0003677	DNA binding	SFPQ	IDA		Human	PMID:25765647
Molecular Function	GO:0042826	histone deacetylase binding	SFPQ	IPI	UniProtKB:Q13547	Human	PMID:16731528
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:P26599	Human	PMID:10653975
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q96ST3	Human	PMID:11259580
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:P26599	Human	PMID:11514619
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q99497	Human	PMID:15790595
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:P55160	Human	PMID:16417406
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q99497	Human	PMID:16731528
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q8AZK7	Human	PMID:18457437
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q13882	Human	PMID:19439179
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:P52272	Human	PMID:19874820
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q9Y2W1	Human	PMID:20932480
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q15233	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:P41235	Human	PMID:23714182
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q15233	Human	PMID:25765647
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q15233	Human	PMID:25959826
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q03468	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q15233	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:Q15233	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	SFPQ	IPI	UniProtKB:P09012	Human	PMID:9848648
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	UniProtKB:O35973|UniProtKB:O54943	Mouse	MGI:MGI:5444785|PMID:22966205
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	UniProtKB:O35160|UniProtKB:Q06219	Mouse	MGI:MGI:3830409|PMID:19144721
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	UniProtKB:O88609|UniProtKB:Q8R326	Mouse	MGI:MGI:5905264|PMID:23308148
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	UniProtKB:O54943	Mouse	MGI:MGI:5014424|PMID:21680841
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	PR:Q8BIF2-1	Mouse	PMID:21177649
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	PR:O55230	Mouse	PMID:20813759
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	PR:P11416-1	Mouse	PMID:18495661
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	PR:P09065	Mouse	PMID:23863478
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	PR:Q8BIF2-5	Mouse	PMID:21177649
Molecular Function	GO:0005515	protein binding	Sfpq	IPI	UniProtKB:Q62826	Rat	PMID:19874820|RGD:8554703
Molecular Function	GO:0042803	protein homodimerization activity	SFPQ	IPI	UniProtKB:P23246	Human	PMID:25765647
Molecular Function	GO:0003723	RNA binding	SFPQ	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	SFPQ	HDA		Human	PMID:22681889
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Sfpq	IDA		Mouse	MGI:MGI:5014424|PMID:21680841
Cellular Component	GO:0000785	chromatin	SFPQ	IDA		Human	PMID:16731528
Cellular Component	GO:0030425	dendrite	Sfpq	IPI		Mouse	MGI:MGI:3530979|PMID:15312650
Cellular Component	GO:0032839	dendrite cytoplasm	Sfpq	IPI		Mouse	MGI:MGI:3530979|PMID:15312650
Cellular Component	GO:0043005	neuron projection	sfpq	IDA		Zfish	PMID:28392072
Cellular Component	GO:0016363	nuclear matrix	SFPQ	IDA		Human	PMID:19874820
Cellular Component	GO:0005654	nucleoplasm	SFPQ	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SFPQ	IDA		Human	PMID:19874820
Cellular Component	GO:0005634	nucleus	SFPQ	IDA		Human	PMID:15790595
Cellular Component	GO:0005634	nucleus	sfpq	IDA		Zfish	PMID:28392072
Cellular Component	GO:0042382	paraspeckles	SFPQ	IDA		Human	PMID:19874820
Cellular Component	GO:0042382	paraspeckles	SFPQ	IDA		Human	PMID:25765647
Cellular Component	GO:0042382	paraspeckles	Sfpq	IDA		Mouse	PMID:21444682
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Sfpq	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Biological Process	GO:0002218	activation of innate immune response	SFPQ	IDA		Human	PMID:28712728
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	SFPQ	IMP		Human	PMID:19874820
Biological Process	GO:0007420	brain development	sfpq	IMP	ZFIN:ZDB-MRPHLNO-070629-5	Zfish	PMID:17393485
Biological Process	GO:0007420	brain development	sfpq	IMP	ZFIN:ZDB-GENO-980202-1106	Zfish	PMID:17393485
Biological Process	GO:0021955	central nervous system neuron axonogenesis	sfpq	IMP	ZFIN:ZDB-GENO-170922-5	Zfish	PMID:28392072
Biological Process	GO:0006338	chromatin remodeling	Sfpq	IMP		Mouse	MGI:MGI:5014424|PMID:21680841
Biological Process	GO:0051276	chromosome organization	Sfpq	IMP		Mouse	PMID:20813759
Biological Process	GO:0098963	dendritic transport of messenger ribonucleoprotein complex	Sfpq	IDA		Mouse	PMID:15312650
Biological Process	GO:0098963	dendritic transport of messenger ribonucleoprotein complex	Sfpq	IMP		Mouse	PMID:15312650
Biological Process	GO:0098963	dendritic transport of messenger ribonucleoprotein complex	Sfpq	IPI		Mouse	PMID:15312650
Biological Process	GO:0006974	DNA damage response	Sfpq	IMP		Mouse	PMID:20813759
Biological Process	GO:0000724	double-strand break repair via homologous recombination	SFPQ	IMP		Human	PMID:20813759
Biological Process	GO:0048859	formation of anatomical boundary	sfpq	IMP	ZFIN:ZDB-GENO-170922-5	Zfish	PMID:28392072
Biological Process	GO:0021547	midbrain-hindbrain boundary initiation	sfpq	IMP	ZFIN:ZDB-GENO-170922-5	Zfish	PMID:28392072
Biological Process	GO:0048681	negative regulation of axon regeneration	sfpq	IMP	ZFIN:ZDB-MRPHLNO-070629-5	Zfish	PMID:24523552
Biological Process	GO:0048681	negative regulation of axon regeneration	sfpq	IMP	ZFIN:ZDB-MRPHLNO-140620-1	Zfish	PMID:24523552
Biological Process	GO:0042754	negative regulation of circadian rhythm	Sfpq	IMP		Mouse	MGI:MGI:5014424|PMID:21680841
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sfpq	IDA		Mouse	MGI:MGI:5444785|PMID:22966205
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sfpq	IMP		Mouse	MGI:MGI:5014424|PMID:21680841
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SFPQ	IGI	UniProtKB:Q15233	Human	PMID:15790595
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SFPQ	IDA		Human	PMID:16731528
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SFPQ	IMP		Human	PMID:22783022
Biological Process	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	SFPQ	IDA		Human	PMID:15790595
Biological Process	GO:0045876	positive regulation of sister chromatid cohesion	Sfpq	IMP		Mouse	PMID:20813759
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SFPQ	IMP		Human	PMID:25765647
Biological Process	GO:0051726	regulation of cell cycle	Sfpq	IMP		Mouse	PMID:20813759
Biological Process	GO:0042752	regulation of circadian rhythm	Sfpq	IMP		Mouse	MGI:MGI:5444785|PMID:22966205
Biological Process	GO:0021654	rhombomere boundary formation	sfpq	IMP	ZFIN:ZDB-GENO-170922-5	Zfish	PMID:28392072
Biological Process	GO:0021522	spinal cord motor neuron differentiation	sfpq	IMP	ZFIN:ZDB-GENO-170922-5	Zfish	PMID:28392072
Biological Process	GO:0021591	ventricular system development	sfpq	IMP	ZFIN:ZDB-GENO-980202-1106	Zfish	PMID:9007241
Biological Process	GO:0021591	ventricular system development	sfpq	IMP	ZFIN:ZDB-GENO-980202-399	Zfish	PMID:9007238
Biological Process	GO:0021591	ventricular system development	sfpq	IMP	ZFIN:ZDB-GENO-980202-399	Zfish	PMID:9007241

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern