Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sfrp2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SFRP2
- Mouse genes Sfrp2
- Rat genes Sfrp2
- Zfish genes sfrp2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sfrp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061133	endopeptidase activator activity	Sfrp2	IDA		Mouse	PMID:19079247
Molecular Function	GO:0008047	enzyme activator activity	Sfrp2	IDA		Mouse	PMID:19079247
Molecular Function	GO:0005515	protein binding	Sfrp2	IPI	UniProtKB:P13497-2	Mouse	MGI:MGI:5917067\|PMID:21078975
Molecular Function	GO:0005515	protein binding	Sfrp2	IPI	PR:P98063	Mouse	PMID:19079247
Molecular Function	GO:0005515	protein binding	Sfrp2	IPI	PR:P22724	Mouse	PMID:9853965
Molecular Function	GO:0005515	protein binding	Sfrp2	IPI	UniProtKB:P09615	Mouse	PMID:9096311
Molecular Function	GO:0048018	receptor ligand activity	Sfrp2	IDA		Mouse	MGI:MGI:4837797\|PMID:20723538
Molecular Function	GO:0017147	Wnt-protein binding	Sfrp2	IPI	PR:P22725	Mouse	PMID:17462603
Molecular Function	GO:0017147	Wnt-protein binding	Sfrp2	IPI	PR:P27467	Mouse	PMID:17462603
Cellular Component	GO:0005615	extracellular space	SFRP2	IDA		Human	PMID:10980594
Cellular Component	GO:0005615	extracellular space	Sfrp2	IDA		Mouse	MGI:MGI:4835156\|PMID:9391078
Cellular Component	GO:0005615	extracellular space	Sfrp2	IDA		Mouse	MGI:MGI:4835154\|PMID:10980594
Cellular Component	GO:0005615	extracellular space	Sfrp2	IDA		Mouse	MGI:MGI:1349347\|PMID:10654605
Biological Process	GO:0009952	anterior/posterior pattern specification	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:16467359
Biological Process	GO:0006915	apoptotic process	Sfrp2	IMP	MGI:MGI:3810257	Mouse	PMID:18729207
Biological Process	GO:0030509	BMP signaling pathway	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19850029
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Sfrp2	IDA		Mouse	MGI:MGI:4835126\|PMID:19458075
Biological Process	GO:0060070	canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19850029
Biological Process	GO:0060070	canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:1329040	Mouse	PMID:18257070
Biological Process	GO:0060070	canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0060070	canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:98956	Mouse	PMID:19896444
Biological Process	GO:0060070	canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19896444
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	SFRP2	IMP		Human	PMID:19593212
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	Sfrp2	IDA		Mouse	PMID:17251350
Biological Process	GO:0051216	cartilage development	Sfrp2	IMP	MGI:MGI:3810257	Mouse	PMID:18729207
Biological Process	GO:0031668	cellular response to extracellular stimulus	Sfrp2	IDA		Mouse	PMID:10322635
Biological Process	GO:0071481	cellular response to X-ray	Sfrp2	IDA		Mouse	MGI:MGI:4835111\|PMID:19778523
Biological Process	GO:0002063	chondrocyte development	Sfrp2	IMP	MGI:MGI:3810257	Mouse	PMID:18729207
Biological Process	GO:0030199	collagen fibril organization	Sfrp2	IMP	MGI:MGI:3664776	Mouse	PMID:19079247
Biological Process	GO:0060028	convergent extension involved in axis elongation	Sfrp2	IGI	MGI:MGI:108078	Mouse	PMID:18257070
Biological Process	GO:0060028	convergent extension involved in axis elongation	Sfrp2	IGI	MGI:MGI:1860298	Mouse	PMID:18257070
Biological Process	GO:0046546	development of primary male sexual characteristics	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19100252
Biological Process	GO:0048546	digestive tract morphogenesis	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19300477
Biological Process	GO:0048546	digestive tract morphogenesis	Sfrp2	IGI	MGI:MGI:1860298	Mouse	PMID:19300477
Biological Process	GO:0048546	digestive tract morphogenesis	Sfrp2	IGI	MGI:MGI:2135272	Mouse	PMID:19300477
Biological Process	GO:0042733	embryonic digit morphogenesis	Sfrp2	IMP	MGI:MGI:3810257	Mouse	PMID:18729207
Biological Process	GO:0071425	hematopoietic stem cell proliferation	Sfrp2	IDA		Mouse	MGI:MGI:4835111\|PMID:19778523
Biological Process	GO:0008584	male gonad development	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19100252
Biological Process	GO:0007501	mesodermal cell fate specification	Sfrp2	IGI	MGI:MGI:98956	Mouse	PMID:17462603
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19850029
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Sfrp2	IDA		Mouse	PMID:19850029
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SFRP2	IDA		Human	PMID:17471511
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:98956	Mouse	PMID:19896444
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19896444
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:1329040	Mouse	PMID:18257070
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp2	IDA		Mouse	PMID:17804636
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:98956	Mouse	PMID:17462603
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19850029
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Sfrp2	IGI	UniProtKB:P27467	Rat	PMID:24080158\|RGD:10448946
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Sfrp2	IDA		Mouse	PMID:17251350
Biological Process	GO:0030308	negative regulation of cell growth	SFRP2	IDA		Human	PMID:20208569
Biological Process	GO:0030336	negative regulation of cell migration	Sfrp2	IDA		Mouse	MGI:MGI:4835154\|PMID:10980594
Biological Process	GO:0008285	negative regulation of cell population proliferation	SFRP2	IMP		Human	PMID:17848950
Biological Process	GO:0008285	negative regulation of cell population proliferation	SFRP2	IDA		Human	PMID:20208569
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Sfrp2	IDA		Mouse	PMID:17251350
Biological Process	GO:0061185	negative regulation of dermatome development	Sfrp2	IDA		Mouse	MGI:MGI:1349347\|PMID:10654605
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	SFRP2	IDA		Human	PMID:19095296
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	SFRP2	IDA		Human	PMID:19095296
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	SFRP2	IDA		Human	PMID:19095296
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Sfrp2	IDA		Mouse	MGI:MGI:4835156\|PMID:9391078
Biological Process	GO:0010629	negative regulation of gene expression	Sfrp2	IDA		Mouse	MGI:MGI:4835154\|PMID:10980594
Biological Process	GO:0043508	negative regulation of JUN kinase activity	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19300477
Biological Process	GO:0043508	negative regulation of JUN kinase activity	Sfrp2	IGI	MGI:MGI:1860298	Mouse	PMID:19300477
Biological Process	GO:0042662	negative regulation of mesodermal cell fate specification	Sfrp2	IGI	MGI:MGI:98956	Mouse	PMID:17462603
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Sfrp2	IDA		Mouse	MGI:MGI:4835154\|PMID:10980594
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	Sfrp2	IGI	MGI:MGI:2135272	Mouse	PMID:18257070
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	Sfrp2	IGI	MGI:MGI:1860298	Mouse	PMID:18257070
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	SFRP2	IDA		Human	PMID:20208569
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Sfrp2	IDA		Mouse	MGI:MGI:5700314\|PMID:11357136
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Sfrp2	IDA		Mouse	MGI:MGI:1349347\|PMID:10654605
Biological Process	GO:0001843	neural tube closure	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19850029
Biological Process	GO:0021915	neural tube development	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19850029
Biological Process	GO:0003151	outflow tract morphogenesis	SFRP2	IMP		Human	PMID:19593212
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	Sfrp2	IGI	MGI:MGI:1860298	Mouse	PMID:18257070
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	Sfrp2	IGI	MGI:MGI:2135272	Mouse	PMID:18257070
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Sfrp2	IGI	MGI:MGI:2135272	Mouse	PMID:18257070
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Sfrp2	IGI	MGI:MGI:1860298	Mouse	PMID:18257070
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0045766	positive regulation of angiogenesis	Sfrp2	IDA		Mouse	MGI:MGI:4835126\|PMID:19458075
Biological Process	GO:0043065	positive regulation of apoptotic process	SFRP2	IMP		Human	PMID:17848950
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Sfrp2	IDA		Mouse	MGI:MGI:4837797\|PMID:20723538
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Sfrp2	IDA		Mouse	MGI:MGI:5700300\|PMID:19001373
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Sfrp2	IGI	MGI:MGI:98956	Mouse	PMID:18166153
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Sfrp2	IGI	UniProtKB:P27467	Rat	PMID:24080158\|RGD:10448946
Biological Process	GO:0030307	positive regulation of cell growth	Sfrp2	IDA		Mouse	MGI:MGI:4835154\|PMID:10980594
Biological Process	GO:0008284	positive regulation of cell population proliferation	SFRP2	IDA		Human	PMID:10980594
Biological Process	GO:0008284	positive regulation of cell population proliferation	Sfrp2	IDA		Mouse	MGI:MGI:4835154\|PMID:10980594
Biological Process	GO:0010950	positive regulation of endopeptidase activity	Sfrp2	IDA		Mouse	PMID:19079247
Biological Process	GO:0045600	positive regulation of fat cell differentiation	SFRP2	IDA		Human	PMID:12055200
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Sfrp2	IGI	MGI:MGI:98956	Mouse	PMID:18166153
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Sfrp2	IDA		Mouse	MGI:MGI:4837797\|PMID:20723538
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sfrp2	IDA		Mouse	MGI:MGI:4837797\|PMID:20723538
Biological Process	GO:0036342	post-anal tail morphogenesis	Sfrp2	IMP	MGI:MGI:3810257	Mouse	PMID:18729207
Biological Process	GO:0042981	regulation of apoptotic process	Sfrp2	IMP	MGI:MGI:3810257	Mouse	PMID:18729207
Biological Process	GO:0042127	regulation of cell population proliferation	Sfrp2	IMP	MGI:MGI:3810257	Mouse	PMID:18729207
Biological Process	GO:0090175	regulation of establishment of planar polarity	Sfrp2	IGI	MGI:MGI:2135272	Mouse	PMID:19300477
Biological Process	GO:0090175	regulation of establishment of planar polarity	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:19300477
Biological Process	GO:0090175	regulation of establishment of planar polarity	Sfrp2	IGI	MGI:MGI:1860298	Mouse	PMID:19300477
Biological Process	GO:1904956	regulation of midbrain dopaminergic neuron differentiation	Sfrp2	IGI	UniProtKB:Q8C4U3	Mouse	MGI:MGI:5448935\|PMID:22290867
Biological Process	GO:0010975	regulation of neuron projection development	Sfrp2	IDA		Mouse	MGI:MGI:5448935\|PMID:22290867
Biological Process	GO:2000035	regulation of stem cell division	Sfrp2	IDA		Mouse	MGI:MGI:4835111\|PMID:19778523
Biological Process	GO:0030111	regulation of Wnt signaling pathway	Sfrp2	IDA		Mouse	MGI:MGI:4835156\|PMID:9391078
Biological Process	GO:0007584	response to nutrient	Sfrp2	IEP		Rat	PMID:17341692\|RGD:4107716
Biological Process	GO:0009410	response to xenobiotic stimulus	Sfrp2	IDA		Mouse	MGI:MGI:4835111\|PMID:19778523
Biological Process	GO:0061056	sclerotome development	Sfrp2	IEP		Mouse	MGI:MGI:1349347\|PMID:10654605
Biological Process	GO:0001756	somitogenesis	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:16467359
Biological Process	GO:0048866	stem cell fate specification	Sfrp2	IGI	MGI:MGI:98956	Mouse	PMID:17462603
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	Sfrp2	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	Sfrp2	IGI	MGI:MGI:1329040	Mouse	PMID:18257070

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.