Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SFRP5
  • Mouse genes Sfrp5
  • Rat genes Sfrp5
  • Zfish genes sfrp5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sfrp5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Biological Process	GO:0060070	canonical Wnt signaling pathway	sfrp5	IMP		Zfish	ZFIN:ZDB-PUB-130605-16
Biological Process	GO:0061386	closure of optic fissure	sfrp5	IGI	ZFIN:ZDB-GENE-040310-5	Zfish	PMID:24457098
Biological Process	GO:0060028	convergent extension involved in axis elongation	Sfrp5	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0060028	convergent extension involved in axis elongation	Sfrp5	IGI	MGI:MGI:108078	Mouse	PMID:18257070
Biological Process	GO:0048546	digestive tract morphogenesis	Sfrp5	IGI	MGI:MGI:2135272	Mouse	PMID:19300477
Biological Process	GO:0048546	digestive tract morphogenesis	Sfrp5	IGI	MGI:MGI:108078	Mouse	PMID:19300477
Biological Process	GO:0048546	digestive tract morphogenesis	Sfrp5	IGI	MGI:MGI:892014	Mouse	PMID:19300477
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	sfrp5	IGI	ZFIN:ZDB-GENE-040310-5	Zfish	PMID:24457098
Biological Process	GO:0061031	endodermal digestive tract morphogenesis	sfrp5	IMP	ZFIN:ZDB-MRPHLNO-130710-3	Zfish	PMID:23638093
Biological Process	GO:0001654	eye development	sfrp5	IGI	ZFIN:ZDB-GENE-980526-332	Zfish	PMID:16854974
Biological Process	GO:0030900	forebrain development	sfrp5	IDA		Zfish	PMID:17222974
Biological Process	GO:0030900	forebrain development	sfrp5	IDA		Zfish	PMID:16854974
Biological Process	GO:0072576	liver morphogenesis	sfrp5	IMP	ZFIN:ZDB-MRPHLNO-130710-3	Zfish	PMID:23638093
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SFRP5	IMP		Human	PMID:19957335
Biological Process	GO:0008285	negative regulation of cell population proliferation	SFRP5	IMP		Human	PMID:19957335
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	SFRP5	IMP		Human	PMID:19957335
Biological Process	GO:0043508	negative regulation of JUN kinase activity	Sfrp5	IGI	MGI:MGI:108078	Mouse	PMID:19300477
Biological Process	GO:0043508	negative regulation of JUN kinase activity	Sfrp5	IGI	MGI:MGI:892014	Mouse	PMID:19300477
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	Sfrp5	IGI	MGI:MGI:108078	Mouse	PMID:18257070
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	Sfrp5	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	Sfrp5	IGI	MGI:MGI:2135272	Mouse	PMID:18257070
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	SFRP5	IMP		Human	PMID:19957335
Biological Process	GO:2000057	negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis	SFRP5	IMP		Human	PMID:18981481
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	sfrp5	IMP		Zfish	ZFIN:ZDB-PUB-130605-16
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	Sfrp5	IGI	MGI:MGI:108078	Mouse	PMID:18257070
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	Sfrp5	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	Sfrp5	IGI	MGI:MGI:2135272	Mouse	PMID:18257070
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Sfrp5	IGI	MGI:MGI:108078	Mouse	PMID:18257070
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Sfrp5	IGI	MGI:MGI:2135272	Mouse	PMID:18257070
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Sfrp5	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	sfrp5	IGI	ZFIN:ZDB-GENE-040310-5	Zfish	PMID:24457098
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	sfrp5	IGI	ZFIN:ZDB-GENE-040310-5	Zfish	PMID:24457098
Biological Process	GO:0036342	post-anal tail morphogenesis	Sfrp5	IGI	MGI:MGI:108078	Mouse	PMID:16700072
Biological Process	GO:0090175	regulation of establishment of planar polarity	Sfrp5	IGI	MGI:MGI:2135272	Mouse	PMID:19300477
Biological Process	GO:0090175	regulation of establishment of planar polarity	Sfrp5	IGI	MGI:MGI:892014	Mouse	PMID:19300477
Biological Process	GO:0090175	regulation of establishment of planar polarity	Sfrp5	IGI	MGI:MGI:108078	Mouse	PMID:19300477
Biological Process	GO:2000056	regulation of Wnt signaling pathway involved in digestive tract morphogenesis	sfrp5	IGI	ZFIN:ZDB-GENE-011108-2,ZFIN:ZDB-GENO-150729-1	Zfish	PMID:23638093

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern