Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SGK1
  • Mouse genes Sgk1
  • Rat genes Sgk1
  • Zfish genes sgk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sgk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043423	3-phosphoinositide-dependent protein kinase binding	Sgk1	IPI	RGD:732664	Rat	PMID:10357815|RGD:1642777
Molecular Function	GO:0005515	protein binding	SGK1	IPI	UniProtKB:Q80UE6	Human	PMID:17360471
Molecular Function	GO:0005515	protein binding	SGK1	IPI	UniProtKB:Q8N668	Human	PMID:20237237
Molecular Function	GO:0005515	protein binding	SGK1	IPI	UniProtKB:P49815	Human	PMID:27451907
Molecular Function	GO:0005515	protein binding	SGK1	IPI	UniProtKB:O15182	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SGK1	IPI	UniProtKB:Q969L2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SGK1	IPI	UniProtKB:Q9ULP0-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Sgk1	IPI	UniProtKB:Q99N57|UniProtKB:Q9Z2S7-3	Mouse	MGI:MGI:6092647|PMID:19380724
Molecular Function	GO:0005515	protein binding	Sgk1	IPI	UniProtKB:P69744	Mouse	MGI:MGI:3691711|PMID:15665527
Molecular Function	GO:0004672	protein kinase activity	Sgk1	IDA		Mouse	PMID:15383658
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Sgk1	IDA		Rat	PMID:16982696|RGD:1642763
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	SGK1	IDA		Human	PMID:22797923
Molecular Function	GO:0048156	tau protein binding	Sgk1	IPI	RGD:69329	Rat	PMID:16982696|RGD:1642763
Cellular Component	GO:0005737	cytoplasm	Sgk1	IDA		Rat	PMID:10357815|RGD:1642777
Cellular Component	GO:0005829	cytosol	SGK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043005	neuron projection	Sgk1	IDA		Rat	PMID:16982696|RGD:1642763
Cellular Component	GO:0016607	nuclear speck	SGK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Sgk1	IDA		Rat	PMID:10066787|RGD:1642789
Cellular Component	GO:0005634	nucleus	Sgk1	IDA		Rat	PMID:10357815|RGD:1642777
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Sgk1	IDA		Rat	PMID:10066787|RGD:1642789
Biological Process	GO:1904045	cellular response to aldosterone	Sgk1	IDA		Mouse	PMID:20427473
Biological Process	GO:0032869	cellular response to insulin stimulus	Sgk1	IMP		Rat	PMID:17715136|RGD:8553574
Biological Process	GO:0006974	DNA damage response	Sgk1	IDA		Mouse	PMID:15383658
Biological Process	GO:0043402	glucocorticoid mediated signaling pathway	Sgk1	IMP		Rat	PMID:16982696|RGD:1642763
Biological Process	GO:0006954	inflammatory response	sgk1	IMP	ZFIN:ZDB-MRPHLNO-140804-1	Zfish	PMID:24431232
Biological Process	GO:0006883	intracellular sodium ion homeostasis	Sgk1	IDA		Rat	PMID:11250940|RGD:628514
Biological Process	GO:0007616	long-term memory	Sgk1	IMP		Rat	PMID:11891330|RGD:729761
Biological Process	GO:0007019	microtubule depolymerization	Sgk1	IDA		Rat	PMID:16982696|RGD:1642763
Biological Process	GO:0043066	negative regulation of apoptotic process	Sgk1	IMP		Rat	PMID:15795328|RGD:1642776
Biological Process	GO:0031115	negative regulation of microtubule polymerization	Sgk1	IDA		Rat	PMID:16982696|RGD:1642763
Biological Process	GO:0048812	neuron projection morphogenesis	Sgk1	IDA		Rat	PMID:16982696|RGD:1642763
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Sgk1	IDA		Rat	PMID:16982696|RGD:1642763
Biological Process	GO:0030307	positive regulation of cell growth	Sgk1	IDA		Rat	PMID:15795328|RGD:1642776
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Sgk1	IMP		Rat	PMID:16049181|RGD:1642773
Biological Process	GO:0010765	positive regulation of sodium ion transport	Sgk1	IMP		Rat	PMID:17715136|RGD:8553574
Biological Process	GO:0006468	protein phosphorylation	Sgk1	IDA		Mouse	PMID:15383658
Biological Process	GO:0051726	regulation of cell cycle	Sgk1	IMP		Rat	PMID:10066787|RGD:1642789
Biological Process	GO:0032880	regulation of protein localization	Sgk1	IMP		Rat	PMID:17715136|RGD:8553574
Biological Process	GO:0008542	visual learning	Sgk1	IMP		Rat	PMID:14656333|RGD:1642778

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern