Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SH2B2
  • Mouse genes Sh2b2
  • Rat genes Sh2b2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sh2b2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Sh2b2	IPI	UniProtKB:Q9Z200	Rat	PMID:16824542|RGD:8553391
Molecular Function	GO:0005515	protein binding	SH2B2	IPI	UniProtKB:P22681	Human	PMID:15737992
Molecular Function	GO:0005515	protein binding	SH2B2	IPI	UniProtKB:P22681	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	Sh2b2	IPI	UniProtKB:Q61851	Mouse	MGI:MGI:2179171|PMID:11827956
Molecular Function	GO:0005515	protein binding	Sh2b2	IPI	PR:P05532	Mouse	PMID:10872802
Molecular Function	GO:0005515	protein binding	Sh2b2	IPI	PR:Q3TJD7	Mouse	PMID:15946664
Molecular Function	GO:0005515	protein binding	Sh2b2	IPI	PR:P15208	Mouse	PMID:10196204
Molecular Function	GO:0005515	protein binding	Sh2b2	IPI	PR:Q62120	Mouse	PMID:10872802
Molecular Function	GO:0005515	protein binding	Sh2b2	IPI	PR:P39688	Mouse	PMID:10872802
Molecular Function	GO:0005515	protein binding	Sh2b2	IPI	PR:Q62137	Mouse	PMID:10872802
Molecular Function	GO:0005515	protein binding	Sh2b2	IPI	PR:P48025	Mouse	PMID:10872802
Molecular Function	GO:0042169	SH2 domain binding	SH2B2	IDA		Human	PMID:9233773
Molecular Function	GO:0035591	signaling adaptor activity	SH2B2	IDA		Human	PMID:9233773
Molecular Function	GO:0035591	signaling adaptor activity	Sh2b2	IDA		Mouse	MGI:MGI:1859033|PMID:10872802
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	Sh2b2	IDA		Mouse	PMID:10196204
Cellular Component	GO:0005884	actin filament	Sh2b2	IDA		Mouse	PMID:14993264
Cellular Component	GO:0005737	cytoplasm	SH2B2	IDA		Human	PMID:9989826
Cellular Component	GO:0005886	plasma membrane	SH2B2	IDA		Human	PMID:9989826
Cellular Component	GO:0001726	ruffle	Sh2b2	IDA		Mouse	PMID:15946664
Cellular Component	GO:0001725	stress fiber	Sh2b2	IDA		Mouse	PMID:15946664
Biological Process	GO:0030036	actin cytoskeleton organization	Sh2b2	IMP	MGI:MGI:2680256	Mouse	PMID:14993264
Biological Process	GO:0030036	actin cytoskeleton organization	Sh2b2	IPI	PR:Q3TJD7	Mouse	PMID:15946664
Biological Process	GO:0050853	B cell receptor signaling pathway	SH2B2	IDA		Human	PMID:9233773
Biological Process	GO:0050853	B cell receptor signaling pathway	Sh2b2	IDA		Mouse	PMID:10872802
Biological Process	GO:0001922	B-1 B cell homeostasis	Sh2b2	IMP	MGI:MGI:2680256	Mouse	PMID:14993264
Biological Process	GO:0050873	brown fat cell differentiation	Sh2b2	IDA		Mouse	PMID:18492766
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Sh2b2	IDA		Mouse	PMID:10872802
Biological Process	GO:0008286	insulin receptor signaling pathway	Sh2b2	IDA		Mouse	PMID:10196204
Biological Process	GO:0035556	intracellular signal transduction	Sh2b2	IDA		Mouse	MGI:MGI:1859033|PMID:10872802
Biological Process	GO:0007399	nervous system development	Sh2b2	IMP		Rat	PMID:9856458|RGD:68805
Biological Process	GO:0050776	regulation of immune response	Sh2b2	IMP	MGI:MGI:2680256	Mouse	PMID:14993264
Biological Process	GO:0019222	regulation of metabolic process	Sh2b2	IMP	MGI:MGI:2680256	Mouse	PMID:14578283
Biological Process	GO:0046578	regulation of Ras protein signal transduction	Sh2b2	IDA		Rat	PMID:9856458|RGD:68805

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern