Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SH3BP1
  • Mouse genes Sh3bp1
  • Rat genes Sh3bp1
  • Zfish genes sh3bp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sh3bp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	SH3BP1	IMP		Human	PMID:22891260
Molecular Function	GO:0005096	GTPase activator activity	SH3BP1	IMP		Human	PMID:24841563
Molecular Function	GO:0005096	GTPase activator activity	Sh3bp1	IDA		Mouse	MGI:MGI:74310|PMID:7621827
Molecular Function	GO:0005096	GTPase activator activity	Sh3bp1	IMP		Rat	PMID:21658605|RGD:13210533
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:Q8IYI6	Human	PMID:21658605
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:Q96A65	Human	PMID:21658605
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:P52907	Human	PMID:22891260
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:P55196	Human	PMID:22891260
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:Q0VF96	Human	PMID:22891260
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:Q9Y5K6	Human	PMID:22891260
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:Q15642	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:P02671-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:Q15642-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:Q8IYE0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:Q9NYB9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH3BP1	IPI	UniProtKB:Q9P2A4	Human	PMID:32296183
Molecular Function	GO:0030215	semaphorin receptor binding	SH3BP1	IPI	UniProtKB:Q9Y4D7	Human	PMID:24841563
Molecular Function	GO:0017124	SH3 domain binding	Sh3bp1	IPI	PR:P00520	Mouse	PMID:8438166
Cellular Component	GO:0005912	adherens junction	SH3BP1	IDA		Human	PMID:22891260
Cellular Component	GO:0005923	bicellular tight junction	SH3BP1	IDA		Human	PMID:22891260
Cellular Component	GO:0005923	bicellular tight junction	Sh3bp1	IDA		Mouse	MGI:MGI:6188997|PMID:22891260
Cellular Component	GO:0031252	cell leading edge	SH3BP1	IDA		Human	PMID:21658605
Cellular Component	GO:0031252	cell leading edge	Sh3bp1	IDA		Rat	PMID:21658605|RGD:13210533
Cellular Component	GO:0005829	cytosol	SH3BP1	IDA		Human	PMID:22891260
Cellular Component	GO:0030027	lamellipodium	SH3BP1	IDA		Human	PMID:24841563
Cellular Component	GO:0005634	nucleus	SH3BP1	IDA		Human	PMID:22891260
Cellular Component	GO:0001891	phagocytic cup	SH3BP1	IDA		Human	PMID:26465210
Biological Process	GO:0007015	actin filament organization	SH3BP1	IMP		Human	PMID:22891260
Biological Process	GO:0007015	actin filament organization	SH3BP1	IMP		Human	PMID:26465210
Biological Process	GO:0034329	cell junction assembly	SH3BP1	IMP		Human	PMID:22891260
Biological Process	GO:0016477	cell migration	SH3BP1	IMP		Human	PMID:21658605
Biological Process	GO:0016477	cell migration	Sh3bp1	IMP		Rat	PMID:21658605|RGD:13210533
Biological Process	GO:0045198	establishment of epithelial cell apical/basal polarity	SH3BP1	IMP		Human	PMID:22891260
Biological Process	GO:0046847	filopodium assembly	Sh3bp1	IMP		Rat	PMID:21658605|RGD:13210533
Biological Process	GO:0051058	negative regulation of small GTPase mediated signal transduction	SH3BP1	IMP		Human	PMID:22891260
Biological Process	GO:0051058	negative regulation of small GTPase mediated signal transduction	SH3BP1	IMP		Human	PMID:24841563
Biological Process	GO:0051058	negative regulation of small GTPase mediated signal transduction	SH3BP1	IMP		Human	PMID:26465210
Biological Process	GO:0006911	phagocytosis, engulfment	SH3BP1	IMP		Human	PMID:26465210
Biological Process	GO:0043547	positive regulation of GTPase activity	SH3BP1	IMP		Human	PMID:22891260
Biological Process	GO:0043547	positive regulation of GTPase activity	SH3BP1	IMP		Human	PMID:24841563
Biological Process	GO:0043547	positive regulation of GTPase activity	Sh3bp1	IDA		Mouse	MGI:MGI:74310|PMID:7621827
Biological Process	GO:0043547	positive regulation of GTPase activity	Sh3bp1	IMP		Rat	PMID:21658605|RGD:13210533
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	SH3BP1	IMP		Human	PMID:24841563
Biological Process	GO:0030834	regulation of actin filament depolymerization	SH3BP1	IMP		Human	PMID:24841563
Biological Process	GO:0043535	regulation of blood vessel endothelial cell migration	SH3BP1	IMP		Human	PMID:24841563
Biological Process	GO:0097178	ruffle assembly	Sh3bp1	IMP		Mouse	MGI:MGI:74310|PMID:7621827
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	SH3BP1	IMP		Human	PMID:24841563

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern