Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Shank2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SHANK2
- Mouse genes Shank2
- Rat genes Shank2
- Zfish genes shank2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Shank2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Shank2	IPI	UniProtKB:Q61625	Mouse	MGI:MGI:3852309\|PMID:15207857
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Shank2	IPI	UniProtKB:P23818	Mouse	MGI:MGI:3624607\|PMID:16606358
Molecular Function	GO:0005515	protein binding	SHANK2	IPI	UniProtKB:P50570	Human	PMID:11583995
Molecular Function	GO:0005515	protein binding	SHANK2	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SHANK2	IPI	UniProtKB:P19174	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SHANK2	IPI	UniProtKB:P27986	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SHANK2	IPI	UniProtKB:P46108	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SHANK2	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SHANK2	IPI	UniProtKB:O95835	Human	PMID:32661924
Molecular Function	GO:0005515	protein binding	SHANK2	IPI	UniProtKB:Q14155	Human	PMID:32661924
Molecular Function	GO:0005515	protein binding	Shank2	IPI	RGD:620768	Rat	PMID:10958799\|RGD:633972
Molecular Function	GO:0005515	protein binding	Shank2	IPI	RGD:620768	Rat	PMID:10964907\|RGD:2314401
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:Q9ES28-2	Rat	PMID:12626503\|RGD:8553890
Molecular Function	GO:0005515	protein binding	Shank2	IPI	RGD:61993	Rat	PMID:15632121\|RGD:2314508
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:P26433	Rat	PMID:16293618\|RGD:8553686
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:P13569	Rat	PMID:17244609\|RGD:8553867
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:P14270-31	Rat	PMID:17244609\|RGD:8553867
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:P14270-33	Rat	PMID:17244609\|RGD:8553867
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:P14270-4	Rat	PMID:17244609\|RGD:8553867
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:P14270-5	Rat	PMID:17244609\|RGD:8553867
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:P14270-7	Rat	PMID:17244609\|RGD:8553867
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:P14270-8	Rat	PMID:17244609\|RGD:8553867
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:P14270-9	Rat	PMID:17244609\|RGD:8553867
Molecular Function	GO:0005515	protein binding	Shank2	IPI	UniProtKB:P27732	Rat	PMID:30058071\|RGD:14402445
Molecular Function	GO:0017124	SH3 domain binding	Shank2	IPI	RGD:70941	Rat	PMID:15014124\|RGD:1599734
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank2	IDA		Rat	PMID:21217644\|RGD:13702145
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank2	IMP		Rat	PMID:21217644\|RGD:13702145
Cellular Component	GO:0016324	apical plasma membrane	Shank2	IDA		Rat	PMID:17244609\|RGD:8553867
Cellular Component	GO:0032279	asymmetric synapse	Shank2	IDA		Rat	PMID:10414979\|RGD:634008
Cellular Component	GO:0031526	brush border membrane	Shank2	IDA		Rat	PMID:15917299\|RGD:7243142
Cellular Component	GO:0060170	ciliary membrane	Shank2	IDA		Rat	PMID:18596612\|RGD:8554451
Cellular Component	GO:0043197	dendritic spine	Shank2	IDA		Mouse	MGI:MGI:3852309\|PMID:15207857
Cellular Component	GO:0098978	glutamatergic synapse	Shank2	IDA		Rat	PMID:10414979\|RGD:634008
Cellular Component	GO:0098978	glutamatergic synapse	Shank2	IDA		Rat	PMID:21217644\|RGD:13702145
Cellular Component	GO:0098978	glutamatergic synapse	Shank2	IMP		Rat	PMID:21217644\|RGD:13702145
Cellular Component	GO:0030426	growth cone	Shank2	IDA		Rat	PMID:10958799\|RGD:633972
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Shank2	IDA		Rat	PMID:10414979\|RGD:634008
Cellular Component	GO:0005883	neurofilament	Shank2	IDA		Mouse	MGI:MGI:5306573\|PMID:19299912
Cellular Component	GO:0043005	neuron projection	Shank2	IDA		Mouse	MGI:MGI:5320264\|PMID:21795692
Cellular Component	GO:0043025	neuronal cell body	Shank2	IDA		Rat	PMID:10958799\|RGD:633972
Cellular Component	GO:0001917	photoreceptor inner segment	Shank2	IDA		Mouse	MGI:MGI:5306573\|PMID:19299912
Cellular Component	GO:0001750	photoreceptor outer segment	Shank2	IDA		Mouse	MGI:MGI:5306573\|PMID:19299912
Cellular Component	GO:0005886	plasma membrane	Shank2	IDA		Mouse	MGI:MGI:3852309\|PMID:15207857
Cellular Component	GO:0014069	postsynaptic density	Shank2	IDA		Rat	PMID:10414979\|RGD:634008
Cellular Component	GO:0014069	postsynaptic density	Shank2	IDA		Rat	PMID:15014124\|RGD:1599734
Cellular Component	GO:0014069	postsynaptic density	Shank2	IDA		Rat	PMID:16439662\|RGD:1599732
Cellular Component	GO:0045211	postsynaptic membrane	Shank2	IDA		Mouse	MGI:MGI:3852309\|PMID:15207857
Cellular Component	GO:0048786	presynaptic active zone	Shank2	IDA		Rat	PMID:21119615\|RGD:8554416
Biological Process	GO:0030534	adult behavior	SHANK2	IMP		Human	PMID:20473310
Biological Process	GO:0030534	adult behavior	Shank2	IMP		Mouse	MGI:MGI:5432970\|PMID:22699620
Biological Process	GO:0008344	adult locomotory behavior	Shank2	IMP		Rat	PMID:29970986\|RGD:126790534
Biological Process	GO:0008306	associative learning	Shank2	IMP		Rat	PMID:29970986\|RGD:126790534
Biological Process	GO:0007420	brain development	Shank2	IEP		Rat	PMID:10964907\|RGD:2314401
Biological Process	GO:0035640	exploration behavior	Shank2	IMP		Mouse	MGI:MGI:5432970\|PMID:22699620
Biological Process	GO:0007612	learning	SHANK2	IMP		Human	PMID:20473310
Biological Process	GO:0007612	learning	Shank2	IMP		Mouse	MGI:MGI:5432970\|PMID:22699620
Biological Process	GO:0060292	long-term synaptic depression	Shank2	IMP		Mouse	MGI:MGI:5432970\|PMID:22699620
Biological Process	GO:0060291	long-term synaptic potentiation	Shank2	IMP		Mouse	MGI:MGI:5432970\|PMID:22699620
Biological Process	GO:0007613	memory	Shank2	IMP		Mouse	MGI:MGI:5432970\|PMID:22699620
Biological Process	GO:0035331	negative regulation of hippo signaling	SHANK2	IMP		Human	PMID:32661924
Biological Process	GO:0008284	positive regulation of cell population proliferation	SHANK2	IMP		Human	PMID:32661924
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Shank2	IMP		Mouse	MGI:MGI:5432971\|PMID:22699619
Biological Process	GO:0099175	regulation of postsynapse organization	Shank2	IDA		Rat	PMID:21217644\|RGD:13702145
Biological Process	GO:0099175	regulation of postsynapse organization	Shank2	IMP		Rat	PMID:21217644\|RGD:13702145
Biological Process	GO:0007584	response to nutrient	Shank2	IEP		Rat	PMID:15917299\|RGD:7243142
Biological Process	GO:0009410	response to xenobiotic stimulus	Shank2	IMP		Rat	PMID:29970986\|RGD:126790534
Biological Process	GO:0035176	social behavior	SHANK2	IMP		Human	PMID:20473310
Biological Process	GO:0035176	social behavior	Shank2	IMP		Mouse	MGI:MGI:5432970\|PMID:22699620
Biological Process	GO:0035176	social behavior	Shank2	IMP		Rat	PMID:29970986\|RGD:126790534
Biological Process	GO:0007416	synapse assembly	Shank2	IMP		Mouse	MGI:MGI:5432970\|PMID:22699620
Biological Process	GO:0071625	vocalization behavior	SHANK2	IMP		Human	PMID:20473310
Biological Process	GO:0071625	vocalization behavior	Shank2	IMP		Mouse	MGI:MGI:5432970\|PMID:22699620

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.