Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Shank3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SHANK3
- Mouse genes Shank3
- Rat genes Shank3
- Zfish genes shank3a,shank3b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Shank3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	Shank3	IPI	RGD:620768	Rat	PMID:10958799\|RGD:633972
Molecular Function	GO:0042802	identical protein binding	Shank3	IPI	UniProtKB:Q9JLU4	Rat	PMID:10433268\|RGD:68848
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Shank3	IPI	UniProtKB:P23818	Mouse	MGI:MGI:3624607\|PMID:16606358
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Shank3	IPI	UniProtKB:Q61625	Mouse	MGI:MGI:3852309\|PMID:15207857
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:P19174	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:O75525	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:P07910	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:P12814	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:P21333	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:P55036	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:Q14155	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:Q8IXJ6	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:Q99435	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:Q9NRD5	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:P16333	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:P62993	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SHANK3	IPI	UniProtKB:Q9UQM7	Human	PMID:28130356
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q8BKX1\|UniProtKB:Q91XM9	Mouse	MGI:MGI:6103173\|PMID:29111324
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q5SQX6\|UniProtKB:Q9D415	Mouse	MGI:MGI:6092779\|PMID:28671696
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q8BKX1\|UniProtKB:Q91XM9	Mouse	MGI:MGI:6092779\|PMID:28671696
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q9Z2Y3	Mouse	MGI:MGI:6433715\|PMID:28701918
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:O60741\|UniProtKB:Q9P1Z3\|UniProtKB:Q9UL51	Mouse	MGI:MGI:5919059\|PMID:26966193
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q8BKX1\|UniProtKB:Q91XM9	Mouse	MGI:MGI:6378693\|PMID:28469556
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q9Z2Y3	Mouse	MGI:MGI:6378693\|PMID:28469556
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:P23818	Mouse	MGI:MGI:3624607\|PMID:16606358
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q9Z2Y3	Mouse	MGI:MGI:6092779\|PMID:28671696
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q9Z2Y3	Mouse	MGI:MGI:6103173\|PMID:29111324
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q8BWT5	Mouse	MGI:MGI:6364690\|PMID:31600191
Molecular Function	GO:0005515	protein binding	Shank3	IPI	PR:P35546-2	Mouse	PMID:15569713
Molecular Function	GO:0005515	protein binding	Shank3	IPI	PR:Q60631	Mouse	PMID:15569713
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:P97838	Rat	PMID:10433269\|RGD:8554380
Molecular Function	GO:0005515	protein binding	Shank3	IPI	RGD:621714	Rat	PMID:11509555\|RGD:628460
Molecular Function	GO:0005515	protein binding	Shank3	IPI	RGD:619814	Rat	PMID:12421375\|RGD:11576289
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q9ES28-2	Rat	PMID:12626503\|RGD:8553890
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q8K1Q4	Rat	PMID:16522626\|RGD:8553782
Molecular Function	GO:0005515	protein binding	Shank3	IPI	UniProtKB:Q9QZM5	Rat	PMID:17304222\|RGD:8553800
Molecular Function	GO:0043621	protein self-association	Shank3	IDA		Rat	PMID:16439662\|RGD:1599732
Molecular Function	GO:0044877	protein-containing complex binding	Shank3	IDA		Rat	PMID:16439662\|RGD:1599732
Molecular Function	GO:0097110	scaffold protein binding	Shank3	IPI	UniProtKB:Q62108	Mouse	MGI:MGI:3624607\|PMID:16606358
Molecular Function	GO:0097110	scaffold protein binding	Shank3	IPI	UniProtKB:P97838	Rat	PMID:10433269\|RGD:8554380
Molecular Function	GO:0097110	scaffold protein binding	Shank3	IPI	UniProtKB:Q9Z214	Rat	PMID:10433269\|RGD:8554380
Molecular Function	GO:0017124	SH3 domain binding	Shank3	IPI	RGD:70941	Rat	PMID:15014124\|RGD:1599734
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank3	IDA		Mouse	PMID:27161151
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank3	IEP		Mouse	PMID:27161151
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank3	IMP		Mouse	PMID:27161151
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank3	IDA		Rat	PMID:10433269\|RGD:8554380
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank3	IDA		Rat	PMID:21217644\|RGD:13702145
Molecular Function	GO:0098919	structural constituent of postsynaptic density	Shank3	IMP		Rat	PMID:21217644\|RGD:13702145
Molecular Function	GO:0030160	synaptic receptor adaptor activity	Shank3	IDA		Rat	PMID:10433269\|RGD:8554380
Molecular Function	GO:0008270	zinc ion binding	Shank3	IDA		Rat	PMID:16439662\|RGD:1599732
Cellular Component	GO:0060170	ciliary membrane	Shank3	IDA		Rat	PMID:18596612\|RGD:8554451
Cellular Component	GO:0098978	glutamatergic synapse	Shank3	IDA		Mouse	PMID:27161151
Cellular Component	GO:0098978	glutamatergic synapse	Shank3	IEP		Mouse	PMID:27161151
Cellular Component	GO:0098978	glutamatergic synapse	Shank3	IMP		Mouse	PMID:27161151
Cellular Component	GO:0098978	glutamatergic synapse	Shank3	IDA		Rat	PMID:10433269\|RGD:8554380
Cellular Component	GO:0098978	glutamatergic synapse	Shank3	IDA		Rat	PMID:15894489\|RGD:12050114
Cellular Component	GO:0098978	glutamatergic synapse	Shank3	IDA		Rat	PMID:21217644\|RGD:13702145
Cellular Component	GO:0098978	glutamatergic synapse	Shank3	IMP		Rat	PMID:21217644\|RGD:13702145
Cellular Component	GO:0098978	glutamatergic synapse	Shank3	IDA		Rat	PMID:23719161\|RGD:12050098
Cellular Component	GO:0098978	glutamatergic synapse	Shank3	IMP		Rat	PMID:23719161\|RGD:12050098
Cellular Component	GO:0043005	neuron projection	Shank3	IDA		Mouse	MGI:MGI:5320264\|PMID:21795692
Cellular Component	GO:0044309	neuron spine	Shank3	IDA		Mouse	MGI:MGI:3624607\|PMID:16606358
Cellular Component	GO:0005886	plasma membrane	Shank3	IDA		Mouse	MGI:MGI:3624607\|PMID:16606358
Cellular Component	GO:0014069	postsynaptic density	Shank3	IDA		Rat	PMID:23719161\|RGD:12050098
Cellular Component	GO:0014069	postsynaptic density	Shank3	IMP		Rat	PMID:23719161\|RGD:12050098
Cellular Component	GO:0014069	postsynaptic density	Shank3	IDA		Rat	PMID:10433269\|RGD:8554380
Cellular Component	GO:0014069	postsynaptic density	Shank3	IDA		Rat	PMID:15014124\|RGD:1599734
Cellular Component	GO:0014069	postsynaptic density	Shank3	IDA		Rat	PMID:15894489\|RGD:12050114
Cellular Component	GO:0014069	postsynaptic density	Shank3	IDA		Rat	PMID:16439662\|RGD:1599732
Cellular Component	GO:0014069	postsynaptic density	Shank3	IDA		Rat	PMID:16522626\|RGD:8553782
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Shank3	IDA		Rat	PMID:15894489\|RGD:12050114
Cellular Component	GO:0045202	synapse	Shank3	IDA		Rat	PMID:11509555\|RGD:628460
Biological Process	GO:0030534	adult behavior	SHANK3	IMP		Human	PMID:17173049
Biological Process	GO:0030534	adult behavior	SHANK3	IMP		Human	PMID:21378602
Biological Process	GO:0097113	AMPA glutamate receptor clustering	Shank3	IMP		Mouse	MGI:MGI:5320264\|PMID:21795692
Biological Process	GO:0097113	AMPA glutamate receptor clustering	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:0008306	associative learning	Shank3	IMP		Mouse	PMID:26158416
Biological Process	GO:0048854	brain morphogenesis	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:0048854	brain morphogenesis	shank3a	IMP	ZFIN:ZDB-MRPHLNO-150925-4	Zfish	PMID:25882707
Biological Process	GO:0048854	brain morphogenesis	shank3a	IGI	ZFIN:ZDB-MRPHLNO-150925-4,ZFIN:ZDB-MRPHLNO-150928-10	Zfish	PMID:25882707
Biological Process	GO:0060997	dendritic spine morphogenesis	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:0060997	dendritic spine morphogenesis	Shank3	IMP		Mouse	MGI:MGI:5285139\|PMID:21167025
Biological Process	GO:0060997	dendritic spine morphogenesis	Shank3	IMP	MGI:MGI:5056336	Mouse	PMID:21558424
Biological Process	GO:0001838	embryonic epithelial tube formation	Shank3	IGI	MGI:MGI:97902	Mouse	PMID:15569713
Biological Process	GO:0035640	exploration behavior	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:0010467	gene expression	Shank3	IMP	MGI:MGI:4949738	Mouse	PMID:30116174
Biological Process	GO:0014009	glial cell proliferation	Shank3	IMP	MGI:MGI:5085999	Mouse	PMID:27785461
Biological Process	GO:0097117	guanylate kinase-associated protein clustering	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:0120054	intestinal motility	shank3b	IGI	ZFIN:ZDB-GENO-200313-2	Zfish	PMID:30733854
Biological Process	GO:0120054	intestinal motility	shank3a	IGI	ZFIN:ZDB-GENO-200313-2	Zfish	PMID:30733854
Biological Process	GO:0007612	learning	SHANK3	IMP		Human	PMID:17173049
Biological Process	GO:0007612	learning	SHANK3	IMP		Human	PMID:21378602
Biological Process	GO:0007612	learning	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:0007611	learning or memory	Shank3	IMP	MGI:MGI:5056336	Mouse	PMID:21558424
Biological Process	GO:0040011	locomotion	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:0007626	locomotory behavior	Shank3	IMP	MGI:MGI:5056336	Mouse	PMID:21558424
Biological Process	GO:0035641	locomotory exploration behavior	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:0035641	locomotory exploration behavior	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:0060292	long-term synaptic depression	Shank3	IMP		Mouse	MGI:MGI:5320264\|PMID:21795692
Biological Process	GO:0060291	long-term synaptic potentiation	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:0000165	MAPK cascade	Shank3	IGI	MGI:MGI:95805	Mouse	PMID:15569713
Biological Process	GO:0000165	MAPK cascade	Shank3	IGI	MGI:MGI:97902	Mouse	PMID:15569713
Biological Process	GO:0007613	memory	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Shank3	IDA		Mouse	PMID:27161151
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Shank3	IEP		Mouse	PMID:27161151
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Shank3	IMP		Mouse	PMID:27161151
Biological Process	GO:0032232	negative regulation of actin filament bundle assembly	Shank3	IDA		Mouse	PMID:19208628
Biological Process	GO:0045794	negative regulation of cell volume	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:0061351	neural precursor cell proliferation	Shank3	IMP	MGI:MGI:5085999	Mouse	PMID:27785461
Biological Process	GO:0050885	neuromuscular process controlling balance	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:0097114	NMDA glutamate receptor clustering	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:2000969	positive regulation of AMPA receptor activity	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:0060999	positive regulation of dendritic spine development	Shank3	IMP		Mouse	MGI:MGI:5320264\|PMID:21795692
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Shank3	IMP		Mouse	MGI:MGI:5320264\|PMID:21795692
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Shank3	IMP		Mouse	MGI:MGI:5285139\|PMID:21167025
Biological Process	GO:1900451	positive regulation of glutamate receptor signaling pathway	Shank3	IMP		Mouse	MGI:MGI:5320264\|PMID:21795692
Biological Process	GO:1900451	positive regulation of glutamate receptor signaling pathway	Shank3	IMP		Rat	PMID:21795692\|RGD:7349315
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	Shank3	IMP		Mouse	MGI:MGI:5285139\|PMID:21167025
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Shank3	IMP		Mouse	MGI:MGI:5285139\|PMID:21167025
Biological Process	GO:0051835	positive regulation of synapse structural plasticity	Shank3	IMP		Mouse	MGI:MGI:5285139\|PMID:21167025
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Shank3	IMP		Mouse	MGI:MGI:5285139\|PMID:21167025
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Shank3	IMP		Mouse	MGI:MGI:5320264\|PMID:21795692
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:0097107	postsynaptic density assembly	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:1904717	regulation of AMPA glutamate receptor clustering	Shank3	IMP	MGI:MGI:5056336	Mouse	PMID:21558424
Biological Process	GO:2000822	regulation of behavioral fear response	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	Shank3	IMP		Mouse	MGI:MGI:5320264\|PMID:21795692
Biological Process	GO:2000821	regulation of grooming behavior	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:2000821	regulation of grooming behavior	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:1900452	regulation of long-term synaptic depression	Shank3	IMP		Mouse	MGI:MGI:5320264\|PMID:21795692
Biological Process	GO:1900271	regulation of long-term synaptic potentiation	Shank3	IMP		Mouse	MGI:MGI:5013997\|PMID:21558424
Biological Process	GO:0099175	regulation of postsynapse organization	Shank3	IDA		Rat	PMID:21217644\|RGD:13702145
Biological Process	GO:0099175	regulation of postsynapse organization	Shank3	IMP		Rat	PMID:21217644\|RGD:13702145
Biological Process	GO:0048167	regulation of synaptic plasticity	Shank3	IMP	MGI:MGI:5056336	Mouse	PMID:21558424
Biological Process	GO:0097396	response to interleukin-17	Shank3	IMP	MGI:MGI:4949738	Mouse	PMID:31853066
Biological Process	GO:0035176	social behavior	SHANK3	IMP		Human	PMID:17173049
Biological Process	GO:0035176	social behavior	SHANK3	IMP		Human	PMID:21378602
Biological Process	GO:0035176	social behavior	Shank3	IMP		Mouse	MGI:MGI:5285139\|PMID:21167025
Biological Process	GO:0035176	social behavior	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:0035176	social behavior	Shank3	IMP	MGI:MGI:1857169	Mouse	PMID:31853066
Biological Process	GO:0035176	social behavior	Shank3	IMP	MGI:MGI:4949738	Mouse	PMID:31853066
Biological Process	GO:0035176	social behavior	Shank3	IMP	MGI:MGI:2677631	Mouse	PMID:31853066
Biological Process	GO:0035176	social behavior	Shank3	IMP	MGI:MGI:5056336	Mouse	PMID:21558424
Biological Process	GO:0021773	striatal medium spiny neuron differentiation	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:0036269	swimming behavior	shank3a	IGI	ZFIN:ZDB-MRPHLNO-150925-4,ZFIN:ZDB-MRPHLNO-150928-10	Zfish	PMID:25882707
Biological Process	GO:0036269	swimming behavior	shank3a	IMP	ZFIN:ZDB-MRPHLNO-150925-4	Zfish	PMID:25882707
Biological Process	GO:0007416	synapse assembly	Shank3	IMP		Mouse	MGI:MGI:4948759\|PMID:21423165
Biological Process	GO:0042297	vocal learning	SHANK3	IMP		Human	PMID:17173049
Biological Process	GO:0042297	vocal learning	SHANK3	IMP		Human	PMID:21378602
Biological Process	GO:0071625	vocalization behavior	SHANK3	IMP		Human	PMID:17173049
Biological Process	GO:0071625	vocalization behavior	SHANK3	IMP		Human	PMID:21378602
Biological Process	GO:0071625	vocalization behavior	Shank3	IMP		Mouse	MGI:MGI:5285139\|PMID:21167025
Biological Process	GO:0071625	vocalization behavior	Shank3	IMP	MGI:MGI:5056336	Mouse	PMID:21558424

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.