Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SHC1
  • Mouse genes Shc1
  • Rat genes Shc1
  • Zfish genes shc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Shc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046875	ephrin receptor binding	SHC1	IPI	UniProtKB:P54762	Human	PMID:12925710
Molecular Function	GO:0046875	ephrin receptor binding	Shc1	IPI	UniProtKB:Q8CBF3	Mouse	MGI:MGI:5294305|PMID:12925710
Molecular Function	GO:0048408	epidermal growth factor binding	Shc1	IPI	UniProtKB:Q01279	Mouse	MGI:MGI:3057041|PMID:15467833
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Shc1	IPI	UniProtKB:Q9QX70	Rat	PMID:7513704|RGD:8553924
Molecular Function	GO:0042802	identical protein binding	Shc1	IPI	UniProtKB:P98083-1	Mouse	MGI:MGI:6092658|PMID:18413607
Molecular Function	GO:0005158	insulin receptor binding	SHC1	IPI	UniProtKB:P06213	Human	PMID:7537849
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	SHC1	IPI	UniProtKB:P08069	Human	PMID:7541045
Molecular Function	GO:0140677	molecular function activator activity	Shc1	IDA		Mouse	PMID:12483226
Molecular Function	GO:0140677	molecular function activator activity	Shc1	IDA		Mouse	PMID:7799946
Molecular Function	GO:0005168	neurotrophin TRKA receptor binding	SHC1	IPI	UniProtKB:P04629	Human	PMID:15488758
Molecular Function	GO:0051219	phosphoprotein binding	Shc1	IPI	RGD:2598	Rat	PMID:8910399|RGD:1599952
Molecular Function	GO:0001784	phosphotyrosine residue binding	SHC1	IPI	UniProtKB:O84462	Human	PMID:20624904
Molecular Function	GO:0001784	phosphotyrosine residue binding	SHC1	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0001784	phosphotyrosine residue binding	Shc1	IPI	RGD:2561	Rat	PMID:9271418|RGD:1582133
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:10356320
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P16573	Human	PMID:11694516
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:11827484
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P05067	Human	PMID:11877420
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:12213123
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:12577067
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P06213	Human	PMID:15629149
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:15657067
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q13137	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P21860	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q15303	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P04626	Human	PMID:16843263
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q9UQC2	Human	PMID:19172738
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q05209	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q07889	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:O75131	Human	PMID:20010870
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:20935677
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P03372-4	Human	PMID:20935677
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:21278788
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:21725358
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:22057045
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:23178716
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:23178716
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:23799367
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q9H792	Human	PMID:23846654
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P03495	Human	PMID:24008843
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P21860	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q05209	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q05209	Human	PMID:24412244
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:26551075
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q05209	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:28065597
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P04626	Human	PMID:28065597
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q13137	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:31585087
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q05209	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P04626	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P21860	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:7518560
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q62120	Human	PMID:7535773
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:7542744
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q9PVZ4	Human	PMID:7559478
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:8034616
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:8491186
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:8663178
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:8939605
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:8940013
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:8995379
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:9175774
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:9254595
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P00533	Human	PMID:9544989
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P62993	Human	PMID:9544989
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:Q07889	Human	PMID:9544989
Molecular Function	GO:0005515	protein binding	SHC1	IPI	UniProtKB:P06213	Human	PMID:9593725
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:P35831|UniProtKB:Q9JKF1	Mouse	MGI:MGI:5508573|PMID:20075861
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:5553227|PMID:23452850
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:3778263|PMID:18273058
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:6355823|PMID:11259577
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:P0DMN7|UniProtKB:Q9Z179	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:Q64729	Mouse	MGI:MGI:5755306|PMID:26680585
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:P31809	Mouse	MGI:MGI:3057041|PMID:15467833
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:3687832|PMID:10748054
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:5508319|PMID:7535773
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:5508320|PMID:7529871
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:Q60631|UniProtKB:Q62312|UniProtKB:Q62312|UniProtKB:Q64729	Mouse	MGI:MGI:5508603|PMID:17673906
Molecular Function	GO:0005515	protein binding	Shc1	IPI	PR:Q9Z179	Mouse	PMID:25153088
Molecular Function	GO:0005515	protein binding	Shc1	IPI	PR:Q6P549	Mouse	PMID:14502564
Molecular Function	GO:0005515	protein binding	Shc1	IPI	UniProtKB:P62994	Rat	PMID:11694516|RGD:11041061
Molecular Function	GO:0005515	protein binding	Shc1	IPI	RGD:620795	Rat	PMID:12837289|RGD:1304398
Molecular Function	GO:0005515	protein binding	Shc1	IPI	RGD:68396	Rat	PMID:12933696|RGD:1626126
Molecular Function	GO:0051721	protein phosphatase 2A binding	Shc1	IDA		Rat	PMID:11884620|RGD:729591
Molecular Function	GO:0051721	protein phosphatase 2A binding	Shc1	IPI	RGD:3380	Rat	PMID:11884620|RGD:729591
Molecular Function	GO:0044877	protein-containing complex binding	Shc1	IPI	RGD:3380	Rat	PMID:11884620|RGD:729591
Molecular Function	GO:0044877	protein-containing complex binding	Shc1	IPI	RGD:1353820	Rat	PMID:17274988|RGD:1643181
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Shc1	IPI	UniProtKB:P15209	Mouse	MGI:MGI:3772008|PMID:12367511
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Shc1	IPI	UniProtKB:Q63604	Rat	PMID:9582017|RGD:8554617
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	Shc1	IDA		Mouse	PMID:12483226
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	Shc1	IDA		Mouse	PMID:7799946
Cellular Component	GO:0005737	cytoplasm	Shc1	IDA		Rat	PMID:15375560|RGD:1643188
Cellular Component	GO:0010008	endosome membrane	Shc1	IDA		Rat	PMID:17363458|RGD:1643180
Cellular Component	GO:0005634	nucleus	Shc1	IDA		Rat	PMID:15375560|RGD:1643188
Cellular Component	GO:0005886	plasma membrane	SHC1	IDA		Human	PMID:14676841
Cellular Component	GO:0005886	plasma membrane	Shc1	IDA		Rat	PMID:12837289|RGD:1304398
Cellular Component	GO:0070435	Shc-EGFR complex	Shc1	IDA		Rat	PMID:7513704|RGD:8553924
Biological Process	GO:0030036	actin cytoskeleton organization	Shc1	IMP	MGI:MGI:2384189	Mouse	PMID:10809671
Biological Process	GO:0030036	actin cytoskeleton organization	Shc1	IMP		Rat	PMID:15262993|RGD:1580336
Biological Process	GO:0001525	angiogenesis	Shc1	IMP	MGI:MGI:2384189	Mouse	PMID:10809671
Biological Process	GO:0001525	angiogenesis	shc1	IMP	ZFIN:ZDB-MRPHLNO-130611-6	Zfish	PMID:22096252
Biological Process	GO:0031100	animal organ regeneration	Shc1	IEP		Rat	PMID:15067377|RGD:1643190
Biological Process	GO:0098609	cell-cell adhesion	Shc1	IMP	MGI:MGI:2384189	Mouse	PMID:10809671
Biological Process	GO:0071363	cellular response to growth factor stimulus	SHC1	IDA		Human	PMID:20010870
Biological Process	GO:0032869	cellular response to insulin stimulus	Shc1	IEP		Rat	PMID:11884620|RGD:729591
Biological Process	GO:0042742	defense response to bacterium	SHC1	IMP		Human	PMID:20624904
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Shc1	IDA		Mouse	PMID:23846654
Biological Process	GO:0007507	heart development	Shc1	IMP	MGI:MGI:2384189	Mouse	PMID:10809671
Biological Process	GO:0008286	insulin receptor signaling pathway	Shc1	IDA		Rat	PMID:17925406|RGD:8553954
Biological Process	GO:0008286	insulin receptor signaling pathway	Shc1	IMP		Rat	PMID:7513704|RGD:8553924
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Shc1	IGI	MGI:MGI:96433	Mouse	PMID:12483226
Biological Process	GO:0043066	negative regulation of apoptotic process	SHC1	IMP		Human	PMID:20624904
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	SHC1	IMP		Human	PMID:20624904
Biological Process	GO:0030182	neuron differentiation	Shc1	IMP		Rat	PMID:17274988|RGD:1643181
Biological Process	GO:0031175	neuron projection development	Shc1	IMP		Rat	PMID:15485499|RGD:1643187
Biological Process	GO:0008284	positive regulation of cell population proliferation	Shc1	IMP		Rat	PMID:7513704|RGD:8553924
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SHC1	IMP		Human	PMID:20624904
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	SHC1	IMP		Human	PMID:20624904
Biological Process	GO:0043410	positive regulation of MAPK cascade	SHC1	IDA		Human	PMID:14676841
Biological Process	GO:0043410	positive regulation of MAPK cascade	SHC1	IMP		Human	PMID:20624904
Biological Process	GO:0043410	positive regulation of MAPK cascade	Shc1	IMP	MGI:MGI:2384189	Mouse	PMID:10809671
Biological Process	GO:0043410	positive regulation of MAPK cascade	Shc1	IMP		Rat	PMID:15262993|RGD:1580336
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Shc1	IMP		Rat	PMID:12837289|RGD:1304398
Biological Process	GO:0045907	positive regulation of vasoconstriction	Shc1	IMP		Rat	PMID:16242150|RGD:1643184
Biological Process	GO:0042127	regulation of cell population proliferation	Shc1	IMP		Mouse	PMID:23846654
Biological Process	GO:0006940	regulation of smooth muscle contraction	Shc1	IMP		Rat	PMID:27270176|RGD:12792230
Biological Process	GO:1990839	response to endothelin	Shc1	IMP		Rat	PMID:27270176|RGD:12792230
Biological Process	GO:0051384	response to glucocorticoid	Shc1	IEP		Rat	PMID:10612430|RGD:1643179
Biological Process	GO:0042542	response to hydrogen peroxide	Shc1	IEP		Rat	PMID:16699171|RGD:1643182
Biological Process	GO:0001666	response to hypoxia	Shc1	IEP		Rat	PMID:16439820|RGD:1643183
Biological Process	GO:0032868	response to insulin	Shc1	IEP		Rat	PMID:11954667|RGD:1643178
Biological Process	GO:0035094	response to nicotine	Shc1	IEP		Rat	PMID:17068140|RGD:1643175
Biological Process	GO:0014070	response to organic cyclic compound	Shc1	IEP		Rat	PMID:16699171|RGD:1643182
Biological Process	GO:0009636	response to toxic substance	Shc1	IEP		Rat	PMID:16699171|RGD:1643182

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern