Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SHMT1
  • Mouse genes Shmt1
  • Rat genes Shmt1
  • Zfish genes shmt1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Shmt1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016597	amino acid binding	Shmt1	IPI	CHEBI:16857	Rat	PMID:3110140|RGD:2300383
Molecular Function	GO:0016597	amino acid binding	Shmt1	IPI	CHEBI:17115	Rat	PMID:3110140|RGD:2300383
Molecular Function	GO:0016597	amino acid binding	Shmt1	IPI	CHEBI:28718	Rat	PMID:3110140|RGD:2300383
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT1	IDA		Human	PMID:10995219
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT1	IDA		Human	PMID:17482557
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT1	IDA		Human	PMID:24698160
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT1	IDA		Human	PMID:8505317
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	Shmt1	IGI	MGI:MGI:1277989	Mouse	PMID:19513116
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	Shmt1	IMP	MGI:MGI:1277989	Mouse	PMID:19513116
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	Shmt1	IDA		Rat	PMID:15671219|RGD:1359815
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	Shmt1	IDA		Rat	PMID:3110140|RGD:2300383
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	shmt1	IDA		Zfish	PMID:17664250
Molecular Function	GO:0042802	identical protein binding	SHMT1	IPI	UniProtKB:P34896	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	SHMT1	IPI	UniProtKB:P34896	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	Shmt1	IPI	RGD:1312011	Rat	PMID:3110140|RGD:2300383
Molecular Function	GO:0008732	L-allo-threonine aldolase activity	Shmt1	IDA		Rat	PMID:3110140|RGD:2300383
Molecular Function	GO:0048027	mRNA 5'-UTR binding	SHMT1	IDA		Human	PMID:10995219
Molecular Function	GO:0000900	mRNA regulatory element binding translation repressor activity	SHMT1	IDA		Human	PMID:10995219
Molecular Function	GO:0005515	protein binding	SHMT1	IPI	UniProtKB:P0DMM9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SHMT1	IPI	UniProtKB:P45984	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SHMT1	IPI	UniProtKB:P50213	Human	PMID:30613765
Molecular Function	GO:0005515	protein binding	SHMT1	IPI	UniProtKB:P45984	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	SHMT1	IPI	UniProtKB:P26196	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SHMT1	IPI	UniProtKB:P45984	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SHMT1	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SHMT1	IPI	UniProtKB:Q9H8Y8	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	SHMT1	IDA		Human	PMID:9753690
Molecular Function	GO:0030170	pyridoxal phosphate binding	SHMT1	IDA		Human	PMID:17482557
Molecular Function	GO:0030170	pyridoxal phosphate binding	SHMT1	IDA		Human	PMID:24698160
Molecular Function	GO:0030170	pyridoxal phosphate binding	Shmt1	IDA		Rat	PMID:3110140|RGD:2300383
Molecular Function	GO:0070905	serine binding	SHMT1	IDA		Human	PMID:24698160
Molecular Function	GO:0036094	small molecule binding	SHMT1	IPI	CHEBI:67016	Human	PMID:24698160
Cellular Component	GO:0005829	cytosol	SHMT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	SHMT1	IDA		Human	PMID:17482557
Cellular Component	GO:0005829	cytosol	Shmt1	IDA		Rat	PMID:15671219|RGD:1359815
Cellular Component	GO:0005829	cytosol	Shmt1	IDA		Rat	PMID:3110140|RGD:2300383
Cellular Component	GO:0005829	cytosol	shmt1	IDA		Zfish	PMID:17664250
Cellular Component	GO:0070062	extracellular exosome	SHMT1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SHMT1	HDA		Human	PMID:23533145
Cellular Component	GO:0005739	mitochondrion	Shmt1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Shmt1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005654	nucleoplasm	SHMT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Shmt1	IMP		Mouse	MGI:MGI:3849912|PMID:19513116
Cellular Component	GO:0005634	nucleus	Shmt1	IDA		Mouse	PMID:19513116
Cellular Component	GO:0005634	nucleus	Shmt1	IGI	MGI:MGI:1277989	Mouse	PMID:19513116
Cellular Component	GO:0005634	nucleus	shmt1	IDA		Zfish	PMID:17664250
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Shmt1	IEP		Mouse	PMID:20439489
Biological Process	GO:1904482	cellular response to tetrahydrofolate	SHMT1	IDA		Human	PMID:24698160
Biological Process	GO:0006231	dTMP biosynthetic process	Shmt1	IMP		Mouse	MGI:MGI:3849912|PMID:19513116
Biological Process	GO:0046655	folic acid metabolic process	SHMT1	IDA		Human	PMID:11278996
Biological Process	GO:0006545	glycine biosynthetic process	Shmt1	IDA		Rat	PMID:3110140|RGD:2300383
Biological Process	GO:0019264	glycine biosynthetic process from serine	Shmt1	IDA		Rat	PMID:3110140|RGD:2300383
Biological Process	GO:0006544	glycine metabolic process	SHMT1	IDA		Human	PMID:24698160
Biological Process	GO:0006544	glycine metabolic process	Shmt1	IDA		Rat	PMID:15671219|RGD:1359815
Biological Process	GO:0006565	L-serine catabolic process	SHMT1	IDA		Human	PMID:17482557
Biological Process	GO:0006563	L-serine metabolic process	SHMT1	IDA		Human	PMID:24698160
Biological Process	GO:0017148	negative regulation of translation	SHMT1	IDA		Human	PMID:10995219
Biological Process	GO:0051289	protein homotetramerization	SHMT1	IDA		Human	PMID:24698160
Biological Process	GO:0009113	purine nucleobase biosynthetic process	SHMT1	IDA		Human	PMID:11516159
Biological Process	GO:0035999	tetrahydrofolate interconversion	SHMT1	IDA		Human	PMID:24698160
Biological Process	GO:0035999	tetrahydrofolate interconversion	Shmt1	IMP	MGI:MGI:1277989	Mouse	PMID:19513116
Biological Process	GO:0046653	tetrahydrofolate metabolic process	SHMT1	IDA		Human	PMID:24698160

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern