Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Shmt2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SHMT2
- Mouse genes Shmt2
- Rat genes Shmt2
- Zfish genes shmt2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Shmt2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016597	amino acid binding	Shmt2	IPI	CHEBI:16857	Rat	PMID:3110140\|RGD:2300383
Molecular Function	GO:0016597	amino acid binding	Shmt2	IPI	CHEBI:17115	Rat	PMID:3110140\|RGD:2300383
Molecular Function	GO:0016597	amino acid binding	Shmt2	IPI	CHEBI:28718	Rat	PMID:3110140\|RGD:2300383
Molecular Function	GO:0003682	chromatin binding	SHMT2	IDA		Human	PMID:18063578
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT2	IDA		Human	PMID:17482557
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT2	IDA		Human	PMID:24075985
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT2	IDA		Human	PMID:25619277
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT2	IDA		Human	PMID:29180469
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT2	IDA		Human	PMID:29364879
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT2	IDA		Human	PMID:29452640
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT2	IMP		Human	PMID:33015733
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	SHMT2	IDA		Human	PMID:8505317
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	Shmt2	IGI	MGI:MGI:98299	Mouse	PMID:19513116
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	Shmt2	IMP	MGI:MGI:98299	Mouse	PMID:19513116
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	Shmt2	IDA		Rat	PMID:10457370\|RGD:2300380
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	Shmt2	IDA		Rat	PMID:15671219\|RGD:1359815
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	Shmt2	IDA		Rat	PMID:3110140\|RGD:2300383
Molecular Function	GO:0004372	glycine hydroxymethyltransferase activity	shmt2	IDA		Zfish	PMID:17664250
Molecular Function	GO:0042802	identical protein binding	Shmt2	IPI	RGD:1308582	Rat	PMID:3110140\|RGD:2300383
Molecular Function	GO:0008732	L-allo-threonine aldolase activity	Shmt2	IDA		Rat	PMID:3110140\|RGD:2300383
Molecular Function	GO:0005515	protein binding	SHMT2	IPI	UniProtKB:Q15041	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SHMT2	IPI	UniProtKB:Q96DZ9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SHMT2	IPI	UniProtKB:Q8IZU9	Human	PMID:25902260
Molecular Function	GO:0005515	protein binding	SHMT2	IPI	UniProtKB:Q15041	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	SHMT2	IPI	UniProtKB:Q969L2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	SHMT2	IPI	UniProtKB:Q96DZ9-2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	SHMT2	IPI	UniProtKB:Q96DZ9	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	SHMT2	IPI	UniProtKB:Q9Y376	Human	PMID:32296183
Molecular Function	GO:0030170	pyridoxal phosphate binding	SHMT2	IDA		Human	PMID:25619277
Molecular Function	GO:0030170	pyridoxal phosphate binding	Shmt2	IDA		Rat	PMID:3110140\|RGD:2300383
Molecular Function	GO:0030170	pyridoxal phosphate binding	shmt2	IDA		Zfish	PMID:17664250
Cellular Component	GO:0070552	BRISC complex	SHMT2	IDA		Human	PMID:24075985
Cellular Component	GO:0005737	cytoplasm	SHMT2	IDA		Human	PMID:24075985
Cellular Component	GO:0070062	extracellular exosome	SHMT2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SHMT2	HDA		Human	PMID:20458337
Cellular Component	GO:0015630	microtubule cytoskeleton	SHMT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005743	mitochondrial inner membrane	SHMT2	IDA		Human	PMID:21876188
Cellular Component	GO:0005743	mitochondrial inner membrane	Shmt2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005743	mitochondrial inner membrane	Shmt2	IDA		Rat	PMID:4107181\|RGD:2300394
Cellular Component	GO:0005758	mitochondrial intermembrane space	Shmt2	IDA		Rat	PMID:4107181\|RGD:2300394
Cellular Component	GO:0005759	mitochondrial matrix	SHMT2	IDA		Human	PMID:11516159
Cellular Component	GO:0005759	mitochondrial matrix	SHMT2	IDA		Human	PMID:21876188
Cellular Component	GO:0005759	mitochondrial matrix	Shmt2	IDA		Rat	PMID:4107181\|RGD:2300394
Cellular Component	GO:0042645	mitochondrial nucleoid	SHMT2	IDA		Human	PMID:18063578
Cellular Component	GO:0005739	mitochondrion	SHMT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	SHMT2	IDA		Human	PMID:17482557
Cellular Component	GO:0005739	mitochondrion	SHMT2	IDA		Human	PMID:24075985
Cellular Component	GO:0005739	mitochondrion	Shmt2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Shmt2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Shmt2	IDA		Rat	PMID:10457370\|RGD:2300380
Cellular Component	GO:0005739	mitochondrion	Shmt2	IDA		Rat	PMID:15671219\|RGD:1359815
Cellular Component	GO:0005739	mitochondrion	Shmt2	IDA		Rat	PMID:3110140\|RGD:2300383
Cellular Component	GO:0005739	mitochondrion	shmt2	IDA		Zfish	PMID:17664250
Cellular Component	GO:0005634	nucleus	SHMT2	IDA		Human	PMID:24075985
Cellular Component	GO:0005634	nucleus	Shmt2	IGI	MGI:MGI:98299	Mouse	PMID:19513116
Cellular Component	GO:0005634	nucleus	Shmt2	IDA		Mouse	PMID:19513116
Biological Process	GO:0006545	glycine biosynthetic process	Shmt2	IDA		Rat	PMID:3110140\|RGD:2300383
Biological Process	GO:0019264	glycine biosynthetic process from serine	Shmt2	IDA		Rat	PMID:3110140\|RGD:2300383
Biological Process	GO:0006544	glycine metabolic process	SHMT2	IDA		Human	PMID:25619277
Biological Process	GO:0006544	glycine metabolic process	SHMT2	IDA		Human	PMID:29180469
Biological Process	GO:0006544	glycine metabolic process	SHMT2	IMP		Human	PMID:33015733
Biological Process	GO:0006544	glycine metabolic process	Shmt2	IDA		Rat	PMID:10457370\|RGD:2300380
Biological Process	GO:0006544	glycine metabolic process	Shmt2	IDA		Rat	PMID:15671219\|RGD:1359815
Biological Process	GO:0006564	L-serine biosynthetic process	Shmt2	IDA		Rat	PMID:10457370\|RGD:2300380
Biological Process	GO:0006563	L-serine metabolic process	SHMT2	IDA		Human	PMID:25619277
Biological Process	GO:0006563	L-serine metabolic process	SHMT2	IDA		Human	PMID:29180469
Biological Process	GO:0006563	L-serine metabolic process	SHMT2	IMP		Human	PMID:33015733
Biological Process	GO:0006730	one-carbon metabolic process	SHMT2	IDA		Human	PMID:11516159
Biological Process	GO:0006730	one-carbon metabolic process	SHMT2	IDA		Human	PMID:29180469
Biological Process	GO:0006730	one-carbon metabolic process	SHMT2	IDA		Human	PMID:29364879
Biological Process	GO:0006730	one-carbon metabolic process	SHMT2	IDA		Human	PMID:29452640
Biological Process	GO:0006730	one-carbon metabolic process	SHMT2	IMP		Human	PMID:33015733
Biological Process	GO:0008284	positive regulation of cell population proliferation	Shmt2	IDA		Rat	PMID:12138190\|RGD:2300332
Biological Process	GO:0051289	protein homotetramerization	SHMT2	IDA		Human	PMID:29180469
Biological Process	GO:0070536	protein K63-linked deubiquitination	SHMT2	IMP		Human	PMID:24075985
Biological Process	GO:0051262	protein tetramerization	SHMT2	IDA		Human	PMID:25619277
Biological Process	GO:1903715	regulation of aerobic respiration	SHMT2	IMP		Human	PMID:29364879
Biological Process	GO:1903715	regulation of aerobic respiration	SHMT2	IMP		Human	PMID:29452640
Biological Process	GO:1903715	regulation of aerobic respiration	Shmt2	IMP		Mouse	MGI:MGI:6148506\|PMID:29323231
Biological Process	GO:0070129	regulation of mitochondrial translation	SHMT2	IMP		Human	PMID:29364879
Biological Process	GO:0070129	regulation of mitochondrial translation	SHMT2	IMP		Human	PMID:29452640
Biological Process	GO:0070129	regulation of mitochondrial translation	Shmt2	IMP		Mouse	MGI:MGI:6148666\|PMID:29452640
Biological Process	GO:0070129	regulation of mitochondrial translation	Shmt2	IMP		Mouse	MGI:MGI:6148506\|PMID:29323231
Biological Process	GO:0002082	regulation of oxidative phosphorylation	SHMT2	IMP		Human	PMID:29364879
Biological Process	GO:0002082	regulation of oxidative phosphorylation	SHMT2	IMP		Human	PMID:29452640
Biological Process	GO:0002082	regulation of oxidative phosphorylation	Shmt2	IMP		Mouse	MGI:MGI:6148506\|PMID:29323231
Biological Process	GO:0034340	response to type I interferon	SHMT2	IDA		Human	PMID:24075985
Biological Process	GO:0035999	tetrahydrofolate interconversion	Shmt2	IMP	MGI:MGI:98299	Mouse	PMID:19513116
Biological Process	GO:0046653	tetrahydrofolate metabolic process	SHMT2	IDA		Human	PMID:24075985
Biological Process	GO:0046653	tetrahydrofolate metabolic process	SHMT2	IDA		Human	PMID:25619277

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.