Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SHOX2
  • Mouse genes Shox2
  • Rat genes Shox2
  • Zfish genes shox2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Shox2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043565	sequence-specific DNA binding	Shox2	IDA		Mouse	MGI:MGI:5902677|PMID:23332764
Biological Process	GO:0003209	cardiac atrium morphogenesis	Shox2	IMP	MGI:MGI:3794658	Mouse	PMID:17372176
Biological Process	GO:0060920	cardiac pacemaker cell differentiation	Shox2	IMP		Mouse	MGI:MGI:3836832|PMID:19166829
Biological Process	GO:0003213	cardiac right atrium morphogenesis	Shox2	IMP		Mouse	MGI:MGI:3836832|PMID:19166829
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Shox2	IMP	MGI:MGI:3628798	Mouse	PMID:16537395
Biological Process	GO:0002063	chondrocyte development	Shox2	IMP	MGI:MGI:3605739	Mouse	PMID:17481601
Biological Process	GO:0002062	chondrocyte differentiation	Shox2	IMP		Mouse	PMID:22916278
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	Shox2	IMP	MGI:MGI:3605739	Mouse	PMID:16141225
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Shox2	IMP		Mouse	PMID:22916278
Biological Process	GO:0030326	embryonic limb morphogenesis	Shox2	IMP	MGI:MGI:3628798	Mouse	PMID:16537395
Biological Process	GO:0030326	embryonic limb morphogenesis	Shox2	IMP	MGI:MGI:3605739	Mouse	PMID:17481601
Biological Process	GO:0048598	embryonic morphogenesis	Shox2	IMP	MGI:MGI:3605739	Mouse	PMID:16141225
Biological Process	GO:0060272	embryonic skeletal joint morphogenesis	Shox2	IMP	MGI:MGI:3626291	Mouse	PMID:18514492
Biological Process	GO:0007507	heart development	shox2	IMP	ZFIN:ZDB-MRPHLNO-071220-4	Zfish	PMID:17372176
Biological Process	GO:0007507	heart development	shox2	IMP	ZFIN:ZDB-MRPHLNO-071220-3	Zfish	PMID:17372176
Biological Process	GO:0003170	heart valve development	Shox2	IMP	MGI:MGI:3794658	Mouse	PMID:17372176
Biological Process	GO:0010463	mesenchymal cell proliferation	Shox2	IMP	MGI:MGI:3626291	Mouse	PMID:18514492
Biological Process	GO:0060415	muscle tissue morphogenesis	Shox2	IMP		Mouse	MGI:MGI:4946446|PMID:21156168
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Shox2	IMP		Mouse	MGI:MGI:5285465|PMID:21640717
Biological Process	GO:0001649	osteoblast differentiation	Shox2	IMP	MGI:MGI:3626291	Mouse	PMID:18514492
Biological Process	GO:0050772	positive regulation of axonogenesis	Shox2	IMP		Mouse	MGI:MGI:4946446|PMID:21156168
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Shox2	IMP	MGI:MGI:3626291	Mouse	PMID:18514492
Biological Process	GO:0048743	positive regulation of skeletal muscle fiber development	Shox2	IMP		Mouse	MGI:MGI:4946446|PMID:21156168
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Shox2	IMP	MGI:MGI:3605739	Mouse	PMID:17481601
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Shox2	IMP	MGI:MGI:3626291	Mouse	PMID:18514492
Biological Process	GO:2000172	regulation of branching morphogenesis of a nerve	Shox2	IMP		Mouse	MGI:MGI:4946446|PMID:21156168
Biological Process	GO:0032330	regulation of chondrocyte differentiation	Shox2	IMP	MGI:MGI:3628798	Mouse	PMID:16537395
Biological Process	GO:0008016	regulation of heart contraction	shox2	IMP	ZFIN:ZDB-MRPHLNO-071220-4	Zfish	PMID:23455426
Biological Process	GO:0002027	regulation of heart rate	Shox2	IMP		Mouse	MGI:MGI:3836832|PMID:19166829
Biological Process	GO:0060931	sinoatrial node cell development	Shox2	IMP		Mouse	MGI:MGI:5285465|PMID:21640717
Biological Process	GO:0003163	sinoatrial node development	Shox2	IMP		Mouse	MGI:MGI:3836832|PMID:19166829
Biological Process	GO:0003172	sinoatrial valve development	Shox2	IMP		Mouse	MGI:MGI:3836832|PMID:19166829
Biological Process	GO:0007224	smoothened signaling pathway	Shox2	IMP	MGI:MGI:3605739	Mouse	PMID:17481601
Biological Process	GO:0072089	stem cell proliferation	Shox2	IMP	MGI:MGI:3626291	Mouse	PMID:18514492

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern