Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SHTN1
  • Mouse genes Shtn1
  • Rat genes Shtn1
  • Zfish genes shtn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Shtn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	Shtn1	IDA		Rat	PMID:23453953|RGD:10054078
Molecular Function	GO:0045296	cadherin binding	SHTN1	HDA		Human	PMID:25468996
Molecular Function	GO:0050839	cell adhesion molecule binding	Shtn1	IPI	UniProtKB:Q05695	Rat	PMID:18519736|RGD:10054086
Molecular Function	GO:0019894	kinesin binding	Shtn1	IPI	UniProtKB:Q80WE4	Mouse	MGI:MGI:5505333|PMID:23864681
Molecular Function	GO:0005515	protein binding	SHTN1	IPI	UniProtKB:P05413	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SHTN1	IPI	UniProtKB:P62508	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SHTN1	IPI	UniProtKB:Q6PJR7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SHTN1	IPI	UniProtKB:Q9Y5B8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Shtn1	IPI	PR:Q80WE4	Mouse	PMID:23349951
Molecular Function	GO:0005515	protein binding	Shtn1	IPI	UniProtKB:Q63787	Rat	PMID:17030985|RGD:8554246
Cellular Component	GO:0030424	axon	Shtn1	IDA		Mouse	MGI:MGI:5505333|PMID:23864681
Cellular Component	GO:0044295	axonal growth cone	Shtn1	IDA		Mouse	PMID:23349951
Cellular Component	GO:0044295	axonal growth cone	Shtn1	IDA		Rat	PMID:18519736|RGD:10054086
Cellular Component	GO:0044295	axonal growth cone	Shtn1	IDA		Rat	PMID:23453953|RGD:10054078
Cellular Component	GO:0031252	cell leading edge	Shtn1	IDA		Mouse	MGI:MGI:5505333|PMID:23864681
Cellular Component	GO:0005737	cytoplasm	SHTN1	IDA		Human	PMID:25468996
Cellular Component	GO:0030175	filopodium	Shtn1	IDA		Rat	PMID:18519736|RGD:10054086
Cellular Component	GO:0030175	filopodium	Shtn1	IDA		Rat	PMID:23453953|RGD:10054078
Cellular Component	GO:0030426	growth cone	Shtn1	IDA		Mouse	MGI:MGI:5505333|PMID:23864681
Cellular Component	GO:0030027	lamellipodium	Shtn1	IDA		Rat	PMID:18519736|RGD:10054086
Cellular Component	GO:0030027	lamellipodium	Shtn1	IDA		Rat	PMID:23453953|RGD:10054078
Cellular Component	GO:0005875	microtubule associated complex	Shtn1	IDA		Mouse	MGI:MGI:5505333|PMID:23864681
Cellular Component	GO:0015630	microtubule cytoskeleton	Shtn1	IDA		Mouse	MGI:MGI:5505333|PMID:23864681
Cellular Component	GO:0043204	perikaryon	Shtn1	IDA		Mouse	MGI:MGI:5505333|PMID:23864681
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Shtn1	IDA		Mouse	MGI:MGI:5505333|PMID:23864681
Biological Process	GO:0061573	actin filament bundle retrograde transport	Shtn1	IMP		Rat	PMID:23453953|RGD:10054078
Biological Process	GO:0007409	axonogenesis	Shtn1	IDA		Rat	PMID:17030985|RGD:8554246
Biological Process	GO:0007409	axonogenesis	Shtn1	IMP		Rat	PMID:17439943|RGD:8554472
Biological Process	GO:0032488	Cdc42 protein signal transduction	Shtn1	IDA		Rat	PMID:23453953|RGD:10054078
Biological Process	GO:0060327	cytoplasmic actin-based contraction involved in cell motility	Shtn1	IDA		Rat	PMID:23453953|RGD:10054078
Biological Process	GO:0061163	endoplasmic reticulum polarization	Shtn1	IMP		Mouse	MGI:MGI:5505333|PMID:23864681
Biological Process	GO:0038007	netrin-activated signaling pathway	Shtn1	IDA		Rat	PMID:23453953|RGD:10054078
Biological Process	GO:0048812	neuron projection morphogenesis	Shtn1	IMP		Mouse	MGI:MGI:5505333|PMID:23864681
Biological Process	GO:0045773	positive regulation of axon extension	Shtn1	IDA		Rat	PMID:18519736|RGD:10054086
Biological Process	GO:0045773	positive regulation of axon extension	Shtn1	IDA		Rat	PMID:23453953|RGD:10054078
Biological Process	GO:2001224	positive regulation of neuron migration	SHTN1	IDA		Human	PMID:23864681
Biological Process	GO:2001224	positive regulation of neuron migration	Shtn1	IMP		Mouse	MGI:MGI:5505333|PMID:23864681
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	shtn1	IMP	ZFIN:ZDB-GENO-200520-3	Zfish	PMID:31434971
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	shtn1	IMP	ZFIN:ZDB-GENO-200520-5	Zfish	PMID:31434971
Biological Process	GO:0007265	Ras protein signal transduction	Shtn1	IDA		Rat	PMID:23453953|RGD:10054078
Biological Process	GO:2000114	regulation of establishment of cell polarity	Shtn1	IMP		Mouse	MGI:MGI:5505333|PMID:23864681
Biological Process	GO:2000114	regulation of establishment of cell polarity	Shtn1	IGI	MGI:MGI:2444576	Mouse	PMID:23349951
Biological Process	GO:2001222	regulation of neuron migration	Shtn1	IGI	MGI:MGI:2444576	Mouse	PMID:23349951
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	Shtn1	IDA		Rat	PMID:23453953|RGD:10054078

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern