Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIAH1
  • Mouse genes Siah1a
  • Rat genes Siah1
  • Zfish genes siah1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Siah1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097718	disordered domain specific binding	Siah1a	IPI	UniProtKB:Q9CXW3	Mouse	MGI:MGI:5882894|PMID:15996101
Molecular Function	GO:0042802	identical protein binding	SIAH1	IPI	UniProtKB:Q8IUQ4	Human	PMID:21988832
Molecular Function	GO:0042802	identical protein binding	SIAH1	IPI	UniProtKB:Q8IUQ4	Human	PMID:22493164
Molecular Function	GO:0042802	identical protein binding	SIAH1	IPI	UniProtKB:Q8IUQ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P25054	Human	PMID:11389840
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q16633	Human	PMID:11483518
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q64693	Human	PMID:11483518
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9HB71	Human	PMID:16085652
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q69ZI1	Human	PMID:16230351
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P61086	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:O15265	Human	PMID:21078624
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:O43236-6	Human	PMID:21185211
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P98170	Human	PMID:21185211
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8IXK0	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9UHX1	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P69713	Human	PMID:21878328
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P29692	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8IXK0	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q99836	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9UHX1	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P35372	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:A2RRL9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:O00560	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:O14645	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:O43581	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:O60333	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:O60336	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:O95045	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P05111	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P08237	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P11216	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P14373	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P20591	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P29692	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P29972	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P36406	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P40121	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P41182	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P49427	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P53778	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P61086	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P62805	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P78508	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:P86479	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q01543	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q13394	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q13625-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q14088	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q2TAL8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q53H82	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q59GP6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q5T5P2-6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q6FIE9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q70IA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q7Z3E5-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q86TG7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q86WX3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q86YD7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8IXK0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8IZA0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8N2X6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8N619	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8NEY3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8TAM4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8TAN2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8TBK6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8WTR4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8WUK0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8WW36	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q8WWY3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q92692	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q96B01	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q96B01-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q96DC9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q96HA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q96KM6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9BQ24	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9BTV4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9BVG8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9BW62	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9C029	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9H0A9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9H0B3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9H2K0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9H3P2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9H6R4-4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9HA38	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9NRN7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9NU19	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9NVL8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9UBK9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9UHB7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9UHB7-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9UHX1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9UJV9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9UJX2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9UQR1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9Y4B4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q9Y5T4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:O15169	Human	PMID:28546513
Molecular Function	GO:0005515	protein binding	SIAH1	IPI	UniProtKB:Q15038	Human	PMID:33591310
Molecular Function	GO:0005515	protein binding	Siah1a	IPI	UniProtKB:P97318	Mouse	MGI:MGI:2653684|PMID:12646221
Molecular Function	GO:0005515	protein binding	Siah1a	IPI	UniProtKB:Q27934	Mouse	MGI:MGI:4441266|PMID:16615911
Molecular Function	GO:0005515	protein binding	Siah1	IPI	RGD:3802	Rat	PMID:11786535|RGD:633984
Molecular Function	GO:0005515	protein binding	Siah1	IPI	UniProtKB:P04797	Rat	PMID:15951807|RGD:8554488
Molecular Function	GO:0005515	protein binding	Siah1	IPI	UniProtKB:Q71F54	Rat	PMID:16230351|RGD:8554714
Molecular Function	GO:0005515	protein binding	Siah1	IPI	UniProtKB:P04797	Rat	PMID:19607794|RGD:8553565
Molecular Function	GO:0005515	protein binding	Siah1	IPI	UniProtKB:O88778	Rat	PMID:23403927|RGD:8554101
Molecular Function	GO:0005515	protein binding	Siah1	IPI	UniProtKB:Q9JKS6	Rat	PMID:23403927|RGD:8554101
Molecular Function	GO:0042803	protein homodimerization activity	Siah1a	IPI	UniProtKB:P61092	Mouse	MGI:MGI:4441266|PMID:16615911
Molecular Function	GO:0061630	ubiquitin protein ligase activity	SIAH1	IDA		Human	PMID:23001567
Molecular Function	GO:0061630	ubiquitin protein ligase activity	SIAH1	IMP		Human	PMID:28546513
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Siah1a	IMP		Mouse	MGI:MGI:6867117|PMID:28546513
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	SIAH1	IMP		Human	PMID:21185211
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Siah1a	IDA		Mouse	MGI:MGI:4441266|PMID:16615911
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Siah1	IDA		Rat	PMID:11786535|RGD:633984
Molecular Function	GO:0008270	zinc ion binding	SIAH1	IDA		Human	PMID:11863358
Molecular Function	GO:0008270	zinc ion binding	SIAH1	IDA		Human	PMID:16085652
Molecular Function	GO:0008270	zinc ion binding	Siah1a	IDA		Mouse	MGI:MGI:4441266|PMID:16615911
Cellular Component	GO:0030877	beta-catenin destruction complex	SIAH1	IDA		Human	PMID:16085652
Cellular Component	GO:0005829	cytosol	Siah1	IDA		Rat	PMID:11786535|RGD:633984
Cellular Component	GO:0005829	cytosol	Siah1	IDA		Rat	PMID:15951807|RGD:8554488
Cellular Component	GO:0005769	early endosome	Siah1	IDA		Rat	PMID:11786535|RGD:633984
Cellular Component	GO:0005634	nucleus	Siah1	IDA		Rat	PMID:15951807|RGD:8554488
Cellular Component	GO:0005886	plasma membrane	Siah1	IDA		Rat	PMID:11786535|RGD:633984
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	Siah1a	IMP		Mouse	MGI:MGI:5882894|PMID:15996101
Biological Process	GO:0060070	canonical Wnt signaling pathway	SIAH1	IMP		Human	PMID:28546513
Biological Process	GO:0060070	canonical Wnt signaling pathway	SIAH1	IMP		Human	PMID:32430360
Biological Process	GO:0060070	canonical Wnt signaling pathway	Siah1a	IMP		Mouse	MGI:MGI:6867117|PMID:28546513
Biological Process	GO:0007141	male meiosis I	Siah1a	IMP	MGI:MGI:2183245	Mouse	PMID:11884614
Biological Process	GO:0051402	neuron apoptotic process	Siah1	IMP		Rat	PMID:15951807|RGD:8554488
Biological Process	GO:0043065	positive regulation of apoptotic process	SIAH1	IDA		Human	PMID:21185211
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	SIAH1	IMP		Human	PMID:21185211
Biological Process	GO:0009791	post-embryonic development	Siah1a	IMP	MGI:MGI:2183245	Mouse	PMID:11884614
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	SIAH1	IMP		Human	PMID:28546513
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	SIAH1	IDA		Human	PMID:33591310
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Siah1a	IMP		Mouse	MGI:MGI:6867117|PMID:28546513
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Siah1a	IDA		Mouse	MGI:MGI:4441266|PMID:16615911
Biological Process	GO:0030163	protein catabolic process	SIAH1	IDA		Human	PMID:11389840
Biological Process	GO:0031648	protein destabilization	Siah1	IMP		Rat	PMID:2129524|RGD:727236
Biological Process	GO:0040014	regulation of multicellular organism growth	Siah1a	IMP	MGI:MGI:2183245	Mouse	PMID:11884614
Biological Process	GO:0007283	spermatogenesis	Siah1a	IMP	MGI:MGI:2183245	Mouse	PMID:11884614
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	SIAH1	IDA		Human	PMID:23001567
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Siah1a	IDA		Mouse	MGI:MGI:4441266|PMID:16615911
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Siah1	IDA		Rat	PMID:11786535|RGD:633984
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Siah1	IDA		Rat	PMID:15951807|RGD:8554488

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern