Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIAH2
  • Mouse genes Siah2
  • Rat genes Siah2
  • Zfish genes siah2l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Siah2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SIAH2	IPI	UniProtKB:Q7Z6J0	Human	PMID:21586138
Molecular Function	GO:0005515	protein binding	SIAH2	IPI	UniProtKB:Q92995	Human	PMID:21659512
Molecular Function	GO:0005515	protein binding	SIAH2	IPI	UniProtKB:P35372	Human	PMID:23840749
Molecular Function	GO:0005515	protein binding	SIAH2	IPI	UniProtKB:O95835	Human	PMID:25438054
Molecular Function	GO:0005515	protein binding	SIAH2	IPI	UniProtKB:Q7Z6J0	Human	PMID:25438054
Molecular Function	GO:0005515	protein binding	SIAH2	IPI	UniProtKB:Q9NRM7	Human	PMID:25438054
Molecular Function	GO:0005515	protein binding	SIAH2	IPI	UniProtKB:P20393	Human	PMID:26392558
Molecular Function	GO:0005515	protein binding	SIAH2	IPI	UniProtKB:Q14995	Human	PMID:26392558
Molecular Function	GO:0005515	protein binding	SIAH2	IPI	UniProtKB:O15169	Human	PMID:28546513
Molecular Function	GO:0005515	protein binding	Siah2	IPI	UniProtKB:P10275	Mouse	MGI:MGI:5490696|PMID:23518348
Molecular Function	GO:0005515	protein binding	Siah2	IPI	UniProtKB:Q13227	Mouse	MGI:MGI:5688415|PMID:26070566
Molecular Function	GO:0005515	protein binding	Siah2	IPI	UniProtKB:O08715	Mouse	MGI:MGI:5508596|PMID:18323779
Molecular Function	GO:0005515	protein binding	Siah2	IPI	RGD:3802	Rat	PMID:11786535|RGD:633984
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	Siah2	IDA		Rat	PMID:11786535|RGD:633984
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Siah2	IMP		Mouse	MGI:MGI:6241928|PMID:26392558
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Siah2	IDA		Mouse	MGI:MGI:5688415|PMID:26070566
Cellular Component	GO:0005829	cytosol	SIAH2	IDA		Human	PMID:21586138
Cellular Component	GO:0005829	cytosol	Siah2	IDA		Rat	PMID:11786535|RGD:633984
Cellular Component	GO:0005769	early endosome	Siah2	IDA		Rat	PMID:11786535|RGD:633984
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SIAH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043005	neuron projection	Siah2	IDA		Rat	PMID:11786535|RGD:633984
Cellular Component	GO:0043025	neuronal cell body	Siah2	IDA		Rat	PMID:11786535|RGD:633984
Cellular Component	GO:0005654	nucleoplasm	SIAH2	IDA		Human	GO_REF:0000052
Biological Process	GO:0060070	canonical Wnt signaling pathway	SIAH2	IMP		Human	PMID:28546513
Biological Process	GO:0043066	negative regulation of apoptotic process	SIAH2	IMP		Human	PMID:21586138
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SIAH2	IGI	UniProtKB:P25054	Human	PMID:12952940
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SIAH2	IGI	UniProtKB:P41221	Human	PMID:12952940
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	SIAH2	IMP		Human	PMID:21586138
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	SIAH2	IMP		Human	PMID:21586138
Biological Process	GO:0042752	regulation of circadian rhythm	SIAH2	IMP		Human	PMID:26392558
Biological Process	GO:0042752	regulation of circadian rhythm	Siah2	IMP		Mouse	MGI:MGI:6241928|PMID:26392558
Biological Process	GO:0031396	regulation of protein ubiquitination	Siah2	IDA		Rat	PMID:11786535|RGD:633984
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	SIAH2	IMP		Human	PMID:26392558
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Siah2	IDA		Mouse	MGI:MGI:5688415|PMID:26070566
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Siah2	IMP		Mouse	MGI:MGI:6241928|PMID:26392558

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern