Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIGLEC12,SIGLEC7,SIGLEC8,SIGLEC9
  • Mouse genes Siglece
  • Rat genes Siglec8
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Siglece

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048029	monosaccharide binding	Siglece	IDA		Mouse	PMID:15048729
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:O14735	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:P10620	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:P18859	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q01638-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q13635-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q15848	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q59EV6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q6UXB4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q8IY26	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q96CM8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q96GM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q96LL9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q9NRS4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC12	IPI	UniProtKB:Q9Y548	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC8	IPI	UniProtKB:P04155	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	SIGLEC7	IPI	UniProtKB:B2RUZ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC9	IPI	UniProtKB:O00206	Human	PMID:25187624
Molecular Function	GO:0005515	protein binding	SIGLEC9	IPI	UniProtKB:P11686	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC9	IPI	UniProtKB:P62166	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIGLEC9	IPI	UniProtKB:Q6PL45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Siglece	IPI	UniProtKB:Q9QUK6	Mouse	MGI:MGI:5616258|PMID:25187624
Molecular Function	GO:0005515	protein binding	Siglece	IPI	PR:P29351	Mouse	PMID:11171044
Molecular Function	GO:0033691	sialic acid binding	Siglece	IDA		Mouse	PMID:24227736
Molecular Function	GO:0033691	sialic acid binding	Siglece	IDA		Mouse	PMID:11171044
Cellular Component	GO:0009897	external side of plasma membrane	Siglece	IDA		Mouse	PMID:24227736
Biological Process	GO:0007155	cell adhesion	Siglece	IDA		Mouse	PMID:11171044
Biological Process	GO:0006954	inflammatory response	Siglece	IMP		Mouse	PMID:24227736
Biological Process	GO:0050728	negative regulation of inflammatory response	Siglece	IMP		Mouse	PMID:24227736
Biological Process	GO:0060101	negative regulation of phagocytosis, engulfment	Siglece	IMP		Mouse	PMID:24227736
Biological Process	GO:0060101	negative regulation of phagocytosis, engulfment	Siglece	IDA		Mouse	PMID:24227736
Biological Process	GO:0006911	phagocytosis, engulfment	Siglece	IMP		Mouse	PMID:24227736

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern