Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIGLEC10,SIGLEC11,SIGLEC16
  • Mouse genes Siglecg
  • Rat genes Siglec10
  • Zfish genes bckdhbl,zmp:0000000650
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Siglecg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019902	phosphatase binding	SIGLEC10	IPI	UniProtKB:P29350	Human	PMID:12163025
Molecular Function	GO:0019902	phosphatase binding	SIGLEC11	IPI	UniProtKB:P29350|UniProtKB:Q06124	Human	PMID:11986327
Molecular Function	GO:0005515	protein binding	SIGLEC16	IPI	UniProtKB:O43914	Human	PMID:28100677
Molecular Function	GO:0005515	protein binding	SIGLEC10	IPI	UniProtKB:P24807	Human	PMID:19264983
Molecular Function	GO:0005515	protein binding	SIGLEC10	IPI	UniProtKB:P0DTC2	Human	PMID:32915505
Molecular Function	GO:0005515	protein binding	Siglecg	IPI	UniProtKB:Q6Q899	Mouse	MGI:MGI:5468580|PMID:23374343
Molecular Function	GO:0005515	protein binding	Siglecg	IPI	UniProtKB:P24807	Mouse	MGI:MGI:5913663|PMID:19264983
Molecular Function	GO:0042169	SH2 domain binding	SIGLEC10	IMP		Human	PMID:12163025
Molecular Function	GO:0033691	sialic acid binding	SIGLEC11	IDA		Human	PMID:11986327
Cellular Component	GO:0005886	plasma membrane	SIGLEC10	IDA		Human	PMID:11284738
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Siglecg	IMP		Mouse	PMID:24029230
Biological Process	GO:0050849	negative regulation of calcium-mediated signaling	Siglecg	IGI	UniProtKB:P35329	Mouse	MGI:MGI:4453395|PMID:20200274
Biological Process	GO:0002638	negative regulation of immunoglobulin production	Siglecg	IGI	UniProtKB:P35329	Mouse	MGI:MGI:4453395|PMID:20200274
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding	SIGLEC10	IPI	UniProtKB:P24807	Human	PMID:19264983
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding	Siglecg	IPI	UniProtKB:P24807	Mouse	MGI:MGI:5913663|PMID:19264983
Biological Process	GO:1900426	positive regulation of defense response to bacterium	SIGLEC16	IDA		Human	PMID:28100677
Biological Process	GO:0032755	positive regulation of interleukin-6 production	SIGLEC16	IDA		Human	PMID:28100677
Biological Process	GO:0030888	regulation of B cell proliferation	Siglecg	IMP		Mouse	MGI:MGI:4453395|PMID:20200274
Biological Process	GO:0030888	regulation of B cell proliferation	Siglecg	IGI	UniProtKB:P35329	Mouse	MGI:MGI:4453395|PMID:20200274
Biological Process	GO:0050776	regulation of immune response	Siglecg	IGI	UniProtKB:P35329	Mouse	MGI:MGI:4453395|PMID:20200274

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern