Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIK1
  • Mouse genes Sik1
  • Rat genes Sik1
  • Zfish genes sik1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sik1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	SIK1	IDA		Human	PMID:18348280
Molecular Function	GO:0005524	ATP binding	SIK1	IDA		Human	PMID:14976552
Molecular Function	GO:0005524	ATP binding	Sik1	IDA		Mouse	MGI:MGI:3044497|PMID:15177563
Molecular Function	GO:0008140	cAMP response element binding protein binding	Sik1	IDA		Mouse	MGI:MGI:2389532|PMID:12200423
Molecular Function	GO:0042826	histone deacetylase binding	Sik1	IPI	UniProtKB:Q6NZM9|UniProtKB:Q9Z2V6	Mouse	MGI:MGI:3712602|PMID:17468767
Molecular Function	GO:0000287	magnesium ion binding	SIK1	IDA		Human	PMID:14976552
Molecular Function	GO:0000287	magnesium ion binding	Sik1	IDA		Mouse	MGI:MGI:3044497|PMID:15177563
Molecular Function	GO:0005515	protein binding	SIK1	IPI	UniProtKB:P63104	Human	PMID:16306228
Molecular Function	GO:0005515	protein binding	SIK1	IPI	UniProtKB:P63104	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Sik1	IPI	UniProtKB:Q9WTN3	Mouse	MGI:MGI:5294536|PMID:19244231
Molecular Function	GO:0005515	protein binding	Sik1	IPI	UniProtKB:P06685	Rat	PMID:17939993|RGD:8554378
Molecular Function	GO:0005515	protein binding	Sik1	IPI	UniProtKB:Q4FZT2	Rat	PMID:17939993|RGD:8554378
Molecular Function	GO:0019901	protein kinase binding	SIK1	IPI	UniProtKB:P49841	Human	PMID:18348280
Molecular Function	GO:0019901	protein kinase binding	Sik1	IPI	UniProtKB:P05132	Mouse	MGI:MGI:2389532|PMID:12200423
Molecular Function	GO:0019901	protein kinase binding	Sik1	IPI	UniProtKB:Q63450	Rat	PMID:17939993|RGD:8554378
Molecular Function	GO:0004674	protein serine/threonine kinase activity	SIK1	IDA		Human	PMID:14976552
Molecular Function	GO:0004674	protein serine/threonine kinase activity	SIK1	IDA		Human	PMID:18348280
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Sik1	IDA		Mouse	MGI:MGI:3606826|PMID:16148943
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Sik1	IDA		Mouse	MGI:MGI:3044497|PMID:15177563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Sik1	IDA		Mouse	MGI:MGI:3712602|PMID:17468767
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Sik1	IDA		Mouse	MGI:MGI:5294536|PMID:19244231
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Sik1	IDA		Mouse	PMID:12624099
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Sik1	IMP		Rat	PMID:12530631|RGD:1299210
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Sik1	IDA		Rat	PMID:17939993|RGD:8554378
Cellular Component	GO:0005737	cytoplasm	SIK1	IDA		Human	PMID:16306228
Cellular Component	GO:0005737	cytoplasm	Sik1	IDA		Mouse	MGI:MGI:3710425|PMID:16817901
Cellular Component	GO:0005737	cytoplasm	Sik1	IDA		Mouse	MGI:MGI:2389532|PMID:12200423
Cellular Component	GO:0005737	cytoplasm	Sik1	IDA		Mouse	MGI:MGI:3044497|PMID:15177563
Cellular Component	GO:0005829	cytosol	Sik1	IDA		Rat	PMID:12530631|RGD:1299210
Cellular Component	GO:0005634	nucleus	SIK1	IDA		Human	PMID:16306228
Cellular Component	GO:0005634	nucleus	Sik1	IDA		Mouse	MGI:MGI:3710425|PMID:16817901
Cellular Component	GO:0005634	nucleus	Sik1	IDA		Mouse	MGI:MGI:2389532|PMID:12200423
Cellular Component	GO:0005634	nucleus	Sik1	IDA		Mouse	PMID:12624099
Cellular Component	GO:0005634	nucleus	Sik1	IDA		Rat	PMID:12530631|RGD:1299210
Biological Process	GO:0043276	anoikis	Sik1	IMP		Mouse	MGI:MGI:4887544|PMID:19622832
Biological Process	GO:0055007	cardiac muscle cell differentiation	Sik1	IMP		Mouse	MGI:MGI:4437512|PMID:20140255
Biological Process	GO:0043153	entrainment of circadian clock by photoperiod	Sik1	IMP		Mouse	MGI:MGI:5532783|PMID:23993098
Biological Process	GO:0035556	intracellular signal transduction	SIK1	IDA		Human	PMID:14976552
Biological Process	GO:0035556	intracellular signal transduction	Sik1	IDA		Mouse	MGI:MGI:3044497|PMID:15177563
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	Sik1	IMP		Mouse	MGI:MGI:5532783|PMID:23993098
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	Sik1	IDA		Mouse	MGI:MGI:3606826|PMID:16148943
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	Sik1	IDA		Mouse	MGI:MGI:2389532|PMID:12200423
Biological Process	GO:0045721	negative regulation of gluconeogenesis	Sik1	IDA		Mouse	MGI:MGI:3606826|PMID:16148943
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sik1	IMP		Rat	PMID:12530631|RGD:1299210
Biological Process	GO:0010868	negative regulation of triglyceride biosynthetic process	Sik1	IDA		Mouse	MGI:MGI:5294536|PMID:19244231
Biological Process	GO:2000210	positive regulation of anoikis	SIK1	IMP		Human	PMID:19622832
Biological Process	GO:0046777	protein autophosphorylation	SIK1	IDA		Human	PMID:18348280
Biological Process	GO:0006468	protein phosphorylation	SIK1	IDA		Human	PMID:14976552
Biological Process	GO:0006468	protein phosphorylation	Sik1	IDA		Mouse	MGI:MGI:3044497|PMID:15177563
Biological Process	GO:0006468	protein phosphorylation	Sik1	IDA		Mouse	MGI:MGI:5532783|PMID:23993098
Biological Process	GO:0006468	protein phosphorylation	Sik1	IDA		Mouse	PMID:12624099
Biological Process	GO:0006468	protein phosphorylation	Sik1	IMP		Rat	PMID:12530631|RGD:1299210
Biological Process	GO:0045595	regulation of cell differentiation	Sik1	IEP		Mouse	MGI:MGI:3044497|PMID:15177563
Biological Process	GO:0007346	regulation of mitotic cell cycle	Sik1	IDA		Mouse	MGI:MGI:3044497|PMID:15177563
Biological Process	GO:0010830	regulation of myotube differentiation	Sik1	IDA		Mouse	MGI:MGI:3712602|PMID:17468767
Biological Process	GO:0002028	regulation of sodium ion transport	Sik1	IDA		Rat	PMID:17939993|RGD:8554378

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern