Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIK2
  • Mouse genes Sik2
  • Rat genes Sik2
  • Zfish genes sik2a,sik2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sik2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	SIK2	IDA		Human	PMID:14976552
Molecular Function	GO:0005524	ATP binding	Sik2	IDA		Mouse	MGI:MGI:2662666|PMID:12624099
Molecular Function	GO:0008047	enzyme activator activity	SIK2	IDA		Human	PMID:24129571
Molecular Function	GO:0004857	enzyme inhibitor activity	SIK2	IDA		Human	PMID:26983400
Molecular Function	GO:0004857	enzyme inhibitor activity	Sik2	IMP		Mouse	PMID:21084751
Molecular Function	GO:0004857	enzyme inhibitor activity	Sik2	IDA		Mouse	PMID:21084751
Molecular Function	GO:0000287	magnesium ion binding	SIK2	IDA		Human	PMID:14976552
Molecular Function	GO:0000287	magnesium ion binding	Sik2	IDA		Mouse	MGI:MGI:2662666|PMID:12624099
Molecular Function	GO:0060589	nucleoside-triphosphatase regulator activity	SIK2	IDA		Human	PMID:24129571
Molecular Function	GO:0005515	protein binding	SIK2	IPI	UniProtKB:P55072	Human	PMID:16306228
Molecular Function	GO:0005515	protein binding	SIK2	IPI	UniProtKB:Q9BV73	Human	PMID:20708153
Molecular Function	GO:0005515	protein binding	SIK2	IPI	UniProtKB:P60520	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIK2	IPI	UniProtKB:P27986	Human	PMID:27478041
Molecular Function	GO:0005515	protein binding	SIK2	IPI	UniProtKB:P55072	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Sik2	IPI	UniProtKB:P61809	Mouse	MGI:MGI:5582660|PMID:24561619
Molecular Function	GO:0106310	protein serine kinase activity	SIK2	IDA		Human	PMID:24129571
Molecular Function	GO:0106310	protein serine kinase activity	Sik2	IMP		Mouse	PMID:21084751
Molecular Function	GO:0106310	protein serine kinase activity	Sik2	IDA		Mouse	PMID:21084751
Molecular Function	GO:0004674	protein serine/threonine kinase activity	SIK2	IDA		Human	PMID:14976552
Molecular Function	GO:0004674	protein serine/threonine kinase activity	SIK2	IDA		Human	PMID:18348280
Molecular Function	GO:0004674	protein serine/threonine kinase activity	SIK2	IDA		Human	PMID:26983400
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Sik2	IDA		Mouse	PMID:12624099
Cellular Component	GO:0005737	cytoplasm	Sik2	IDA		Mouse	MGI:MGI:2662666|PMID:12624099
Cellular Component	GO:0005789	endoplasmic reticulum membrane	SIK2	IDA		Human	PMID:24129571
Cellular Component	GO:0005634	nucleus	Sik2	IDA		Mouse	PMID:12624099
Biological Process	GO:0008286	insulin receptor signaling pathway	Sik2	IDA		Mouse	PMID:12624099
Biological Process	GO:0035556	intracellular signal transduction	SIK2	IDA		Human	PMID:14976552
Biological Process	GO:0035556	intracellular signal transduction	Sik2	IDA		Mouse	MGI:MGI:2662666|PMID:12624099
Biological Process	GO:0045820	negative regulation of glycolytic process	Sik2	IMP		Mouse	PMID:21084751
Biological Process	GO:0051055	negative regulation of lipid biosynthetic process	Sik2	IDA		Mouse	PMID:21084751
Biological Process	GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	Sik2	IMP		Mouse	PMID:21084751
Biological Process	GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	Sik2	IDA		Mouse	PMID:21084751
Biological Process	GO:0046777	protein autophosphorylation	SIK2	IDA		Human	PMID:18348280
Biological Process	GO:0006468	protein phosphorylation	SIK2	IDA		Human	PMID:14976552
Biological Process	GO:0006468	protein phosphorylation	Sik2	IDA		Mouse	PMID:12624099
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	Sik2	IDA		Mouse	MGI:MGI:2662666|PMID:12624099

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern