Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIM1
  • Mouse genes Sim1
  • Rat genes Sim1
  • Zfish genes sim1a,sim1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sim1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SIM1	IPI	UniProtKB:Q9HBZ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Sim1	IPI	UniProtKB:P53762	Mouse	MGI:MGI:4455093|PMID:20211142
Molecular Function	GO:0005515	protein binding	Sim1	IPI	UniProtKB:P53762	Mouse	MGI:MGI:86070|PMID:9020169
Molecular Function	GO:0005515	protein binding	Sim1	IPI	PR:Q61324	Mouse	PMID:27782878
Molecular Function	GO:0046982	protein heterodimerization activity	Sim1	IDA		Mouse	MGI:MGI:5824181|PMID:27782878
Molecular Function	GO:0046982	protein heterodimerization activity	Sim1	IPI	UniProtKB:Q61324	Mouse	MGI:MGI:82794|PMID:8927054
Cellular Component	GO:0005634	nucleus	Sim1	IDA		Mouse	PMID:11782478
Biological Process	GO:0007411	axon guidance	sim1a	IMP	ZFIN:ZDB-MRPHLNO-100423-10	Zfish	PMID:23222439
Biological Process	GO:0007411	axon guidance	sim1a	IGI	ZFIN:ZDB-MRPHLNO-100423-10,ZFIN:ZDB-MRPHLNO-100423-8	Zfish	PMID:23222439
Biological Process	GO:0021536	diencephalon development	sim1a	IMP	ZFIN:ZDB-MRPHLNO-060921-2	Zfish	PMID:19234064
Biological Process	GO:0071542	dopaminergic neuron differentiation	sim1a	IMP	ZFIN:ZDB-MRPHLNO-100426-20	Zfish	PMID:19253397
Biological Process	GO:0071542	dopaminergic neuron differentiation	sim1a	IMP	ZFIN:ZDB-MRPHLNO-060921-2	Zfish	PMID:19234064
Biological Process	GO:0071542	dopaminergic neuron differentiation	sim1a	IGI	ZFIN:ZDB-MRPHLNO-050204-2	Zfish	PMID:19253397
Biological Process	GO:0071542	dopaminergic neuron differentiation	sim1a	IMP	ZFIN:ZDB-MRPHLNO-100426-17	Zfish	PMID:19253397
Biological Process	GO:0021979	hypothalamus cell differentiation	sim1a	IMP	ZFIN:ZDB-MRPHLNO-060921-2	Zfish	PMID:19234064
Biological Process	GO:0035776	pronephric proximal tubule development	sim1a	IMP	ZFIN:ZDB-MRPHLNO-060921-2	Zfish	PMID:25542995
Biological Process	GO:0048793	pronephros development	sim1a	IMP	ZFIN:ZDB-MRPHLNO-060921-2	Zfish	PMID:27996936
Biological Process	GO:0072020	proximal straight tubule development	sim1a	IGI	ZFIN:ZDB-GENE-020829-1	Zfish	PMID:30475208
Biological Process	GO:0072020	proximal straight tubule development	sim1a	IMP	ZFIN:ZDB-MRPHLNO-100423-10	Zfish	PMID:30475208
Biological Process	GO:0072020	proximal straight tubule development	sim1a	IMP	ZFIN:ZDB-GENO-190905-10	Zfish	PMID:30475208
Biological Process	GO:0006355	regulation of DNA-templated transcription	Sim1	IDA		Mouse	PMID:11782478
Biological Process	GO:0001657	ureteric bud development	Sim1	IEP		Mouse	MGI:MGI:3655805|PMID:16545622

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern