Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIN3A
  • Mouse genes Sin3a
  • Rat genes Sin3a
  • Zfish genes sin3aa,sin3ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sin3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Sin3a	IDA		Mouse	PMID:18212064
Molecular Function	GO:0003682	chromatin binding	Sin3a	IDA		Mouse	PMID:17074803
Molecular Function	GO:0003677	DNA binding	Sin3a	IDA		Mouse	PMID:14593184
Molecular Function	GO:0003677	DNA binding	Sin3a	IDA		Mouse	PMID:15998811
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:P12755	Human	PMID:10049357
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q13547	Human	PMID:10220385
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:P04637	Human	PMID:10823891
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:P42858	Human	PMID:10823891
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q92922	Human	PMID:11238380
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:P23246	Human	PMID:11259580
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:P04637	Human	PMID:11359905
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:O15294	Human	PMID:12150998
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:P51610	Human	PMID:12670868
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:P12755	Human	PMID:14525983
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q92769	Human	PMID:16254079
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q9UQ80	Human	PMID:16254079
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q9NS56	Human	PMID:17803295
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q13547	Human	PMID:17956988
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q9P1Z0	Human	PMID:18451802
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q13547,UniProtKB:Q92769,UniProtKB:Q9NRA0,UniProtKB:Q9UBB5	Human	PMID:19729656
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q9H160	Human	PMID:20676127
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q13547	Human	PMID:21258344
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q92769	Human	PMID:21258344
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q13547	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q92769	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:P51608	Human	PMID:23770565
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q13547	Human	PMID:25314079
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q92769	Human	PMID:25314079
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q13547	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q13547	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q92769	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q13547	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q9BUL5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q9H160	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:Q9BUL5	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	SIN3A	IPI	UniProtKB:O75446	Human	PMID:9651585
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:O09106|UniProtKB:Q8C8M1	Mouse	MGI:MGI:5908475|PMID:28554894
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:O09106	Mouse	MGI:MGI:4949547|PMID:21448134
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q9Z2D6	Mouse	MGI:MGI:5528617|PMID:23770565
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q91YE5	Mouse	MGI:MGI:3852313|PMID:12198165
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:O09106|UniProtKB:P70288	Mouse	MGI:MGI:5548024|PMID:24240174
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:O88574	Mouse	MGI:MGI:1929573|PMID:9702189
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q8BR65	Mouse	MGI:MGI:2670031|PMID:11909966
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q9WTV7	Mouse	MGI:MGI:4456957|PMID:11882901
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:O09106|UniProtKB:P70288	Mouse	MGI:MGI:3844744|PMID:19424149
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q13127	Mouse	MGI:MGI:1354825|PMID:10734093
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:P70288	Mouse	MGI:MGI:3700432|PMID:15696166
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:O09106|UniProtKB:P70288	Mouse	MGI:MGI:4454226|PMID:20404188
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q9UBP5	Mouse	MGI:MGI:5142378|PMID:11486045
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q9Z2D6	Mouse	MGI:MGI:6716953|PMID:19602036
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q8R5A0	Mouse	MGI:MGI:4943402|PMID:16805913
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q3URK3	Mouse	MGI:MGI:5003384|PMID:21490601
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q06219	Mouse	MGI:MGI:3830409|PMID:19144721
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:P50540	Mouse	MGI:MGI:79478|PMID:8649810
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:O09106,UniProtKB:Q00899,UniProtKB:Q9DB00	Mouse	MGI:MGI:5700293|PMID:21454521
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:P48432	Mouse	MGI:MGI:3844410|PMID:19139101
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:O54943	Mouse	MGI:MGI:5014424|PMID:21680841
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:P85037|UniProtKB:Q3UCQ1	Mouse	MGI:MGI:5615527|PMID:25402684
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	PR:Q5SPL2	Mouse	PMID:11390640
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	PR:Q61909	Mouse	PMID:16227606
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	PR:Q8BR65	Mouse	PMID:15489224
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:O75446	Mouse	PMID:11390640
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q96QT6	Mouse	PMID:11390640
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	PR:Q8C2B3	Mouse	PMID:10640276
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q05195	Mouse	PMID:7889570
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	PR:P97360	Mouse	PMID:12527908
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	PR:O08789	Mouse	PMID:16103876
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	PR:Q921G6	Mouse	PMID:16449650
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	UniProtKB:Q05195	Mouse	PMID:11101889
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	PR:O70374	Mouse	PMID:16227606
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	MGI:MGI:1339639	Mouse	PMID:17670746
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	PR:Q80US8	Mouse	PMID:8521822
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	PR:Q60948	Mouse	PMID:8521822
Molecular Function	GO:0005515	protein binding	Sin3a	IPI	RGD:2859|RGD:3541	Rat	PMID:16776654|RGD:2303551
Molecular Function	GO:0044877	protein-containing complex binding	Sin3a	IDA		Rat	PMID:10491605|RGD:2306469
Molecular Function	GO:0003723	RNA binding	Sin3a	IDA		Rat	PMID:24063527|RGD:9495912
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	SIN3A	IPI	UniProtKB:P40763	Human	PMID:22783022
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Sin3a	IPI	PR:Q8BIA3	Mouse	PMID:19235719
Molecular Function	GO:0003713	transcription coactivator activity	SIN3A	IMP		Human	PMID:22783022
Molecular Function	GO:0003714	transcription corepressor activity	SIN3A	IMP		Human	PMID:22783022
Molecular Function	GO:0003714	transcription corepressor activity	Sin3a	IDA		Mouse	MGI:MGI:1354825|PMID:10734093
Molecular Function	GO:0003714	transcription corepressor activity	Sin3a	IGI	UniProtKB:Q60520	Mouse	MGI:MGI:1354825|PMID:10734093
Molecular Function	GO:0003714	transcription corepressor activity	Sin3a	IDA		Mouse	MGI:MGI:79975|PMID:7889570
Molecular Function	GO:0003714	transcription corepressor activity	Sin3a	IMP	MGI:MGI:3583656	Mouse	PMID:15998811
Molecular Function	GO:0008134	transcription factor binding	Sin3a	IPI	PR:Q03267	Mouse	PMID:15767674
Molecular Function	GO:0008134	transcription factor binding	Sin3a	IPI	PR:Q9Z2D6	Mouse	PMID:14593184
Molecular Function	GO:0140416	transcription regulator inhibitor activity	SIN3A	IDA		Human	PMID:22783022
Cellular Component	GO:0000785	chromatin	Sin3a	IDA		Rat	PMID:16776654|RGD:2303551
Cellular Component	GO:0000118	histone deacetylase complex	SIN3A	IDA		Human	PMID:9651585
Cellular Component	GO:0000776	kinetochore	Sin3a	IDA		Mouse	PMID:14519686
Cellular Component	GO:0005654	nucleoplasm	SIN3A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SIN3A	IDA		Human	PMID:22783022
Cellular Component	GO:0005634	nucleus	Sin3a	IDA		Mouse	MGI:MGI:1354825|PMID:10734093
Cellular Component	GO:0005634	nucleus	Sin3a	IDA		Mouse	MGI:MGI:79478|PMID:8649810
Cellular Component	GO:0032991	protein-containing complex	Sin3a	IDA		Rat	PMID:10491605|RGD:2306469
Cellular Component	GO:0016580	Sin3 complex	SIN3A	IDA		Human	PMID:14966270
Cellular Component	GO:0016580	Sin3 complex	SIN3A	IDA		Human	PMID:17827154
Cellular Component	GO:0005667	transcription regulator complex	Sin3a	IPI	PR:P05627	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Sin3a	IPI	PR:Q9QYB2	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Sin3a	IPI	PR:O09106	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Sin3a	IPI	PR:P70288	Mouse	PMID:17182846
Cellular Component	GO:0005667	transcription regulator complex	Sin3a	IPI	PR:Q60974	Mouse	PMID:17182846
Cellular Component	GO:0017053	transcription repressor complex	Sin3a	IDA		Mouse	MGI:MGI:1354825|PMID:10734093
Cellular Component	GO:0017053	transcription repressor complex	Sin3a	IPI	PR:Q60974	Mouse	PMID:17182846
Cellular Component	GO:0017053	transcription repressor complex	Sin3a	IPI	PR:P05627	Mouse	PMID:17182846
Cellular Component	GO:0017053	transcription repressor complex	Sin3a	IPI	PR:Q9QYB2	Mouse	PMID:17182846
Cellular Component	GO:0017053	transcription repressor complex	Sin3a	IPI	PR:P70288	Mouse	PMID:17182846
Cellular Component	GO:0017053	transcription repressor complex	Sin3a	IPI	PR:O09106	Mouse	PMID:17182846
Biological Process	GO:0002218	activation of innate immune response	SIN3A	IMP		Human	PMID:22783022
Biological Process	GO:0007568	aging	Sin3a	IDA		Rat	PMID:18945670|RGD:2306468
Biological Process	GO:1903351	cellular response to dopamine	Sin3a	IEP		Rat	PMID:15731170|RGD:9495915
Biological Process	GO:0071333	cellular response to glucose stimulus	Sin3a	IDA		Mouse	PMID:17670746
Biological Process	GO:0021895	cerebral cortex neuron differentiation	Sin3a	IMP		Mouse	MGI:MGI:6152283|PMID:27399968
Biological Process	GO:0006260	DNA replication	Sin3a	IMP	MGI:MGI:3583656	Mouse	PMID:15998811
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Sin3a	IMP		Mouse	PMID:24029230
Biological Process	GO:0001701	in utero embryonic development	Sin3a	IMP	MGI:MGI:3583656	Mouse	PMID:15998811
Biological Process	GO:0043066	negative regulation of apoptotic process	Sin3a	IMP	MGI:MGI:3583656	Mouse	PMID:15998811
Biological Process	GO:0042754	negative regulation of circadian rhythm	Sin3a	IMP		Mouse	MGI:MGI:5014424|PMID:21680841
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sin3a	IDA		Mouse	MGI:MGI:1354825|PMID:10734093
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sin3a	IDA		Mouse	MGI:MGI:79975|PMID:7889570
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	SIN3A	IMP		Human	PMID:22783022
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SIN3A	IMP		Human	PMID:22783022
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sin3a	IGI	MGI:MGI:1097691	Mouse	PMID:10431247
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sin3a	IGI	MGI:MGI:1342291	Mouse	PMID:10431247
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sin3a	IGI	MGI:MGI:96908	Mouse	PMID:12649481
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sin3a	IGI	UniProtKB:Q05195	Mouse	PMID:7889570
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	SIN3A	IMP		Human	PMID:22783022
Biological Process	GO:0002230	positive regulation of defense response to virus by host	SIN3A	IMP		Human	PMID:22783022
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	Sin3a	IMP	MGI:MGI:3583656	Mouse	PMID:15998811
Biological Process	GO:0031453	positive regulation of heterochromatin formation	SIN3A	IMP		Human	PMID:22783022
Biological Process	GO:0045666	positive regulation of neuron differentiation	Sin3a	IMP		Mouse	MGI:MGI:6152283|PMID:27399968
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SIN3A	IMP		Human	PMID:22783022
Biological Process	GO:0006476	protein deacetylation	SIN3A	IMP		Human	PMID:22783022
Biological Process	GO:0008104	protein localization	Sin3a	IMP	MGI:MGI:3583656	Mouse	PMID:15998811
Biological Process	GO:0030516	regulation of axon extension	Sin3a	IMP		Mouse	MGI:MGI:6152283|PMID:27399968
Biological Process	GO:0006355	regulation of DNA-templated transcription	Sin3a	IMP	MGI:MGI:3583656	Mouse	PMID:15998811
Biological Process	GO:0010817	regulation of hormone levels	Sin3a	IMP		Rat	PMID:15731170|RGD:9495915
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	Sin3a	IDA		Rat	PMID:18945670|RGD:2306468
Biological Process	GO:0051595	response to methylglyoxal	Sin3a	IDA		Mouse	PMID:17670746
Biological Process	GO:0010243	response to organonitrogen compound	Sin3a	IDA		Rat	PMID:19289167|RGD:2306467

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern