Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIRPA
  • Mouse genes Sirpa
  • Rat genes Sirpa
  • Zfish genes si:ch211-180a12.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sirpa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0098632	cell-cell adhesion mediator activity	SIRPA	IPI	UniProtKB:Q08722	Human	PMID:11509594
Molecular Function	GO:0030695	GTPase regulator activity	Sirpa	IMP		Rat	PMID:16055727|RGD:13792550
Molecular Function	GO:1990405	protein antigen binding	SIRPA	IPI	UniProtKB:Q08722	Human	PMID:24026300
Molecular Function	GO:0005515	protein binding	Sirpa	IPI	UniProtKB:Q9R1X3	Mouse	PMID:11895767
Molecular Function	GO:0005515	protein binding	Sirpa	IPI	PR:Q61735	Mouse	PMID:14634079
Molecular Function	GO:0005515	protein binding	Sirpa	IPI	PR:Q6SJQ7	Mouse	PMID:14662855
Molecular Function	GO:0005515	protein binding	Sirpa	IPI	PR:Q7TSA3	Mouse	PMID:12796776
Molecular Function	GO:0005515	protein binding	Sirpa	IPI	UniProtKB:Q9R044	Rat	PMID:22747997|RGD:8553639
Molecular Function	GO:0005515	protein binding	Sirpa	IPI	UniProtKB:P41499	Rat	PMID:8810330|RGD:729736
Molecular Function	GO:0005515	protein binding	Sirpa	IPI	UniProtKB:Q06124	Rat	PMID:8810330|RGD:729736
Molecular Function	GO:0005515	protein binding	Sirpa	IPI	UniProtKB:Q06124	Rat	PMID:9535915|RGD:8554191
Molecular Function	GO:0086080	protein binding involved in heterotypic cell-cell adhesion	Sirpa	IPI	UniProtKB:P97829	Rat	PMID:16055727|RGD:13792550
Molecular Function	GO:0019903	protein phosphatase binding	Sirpa	IPI	UniProtKB:P29351|UniProtKB:P35235	Mouse	MGI:MGI:3760575|PMID:17954568
Molecular Function	GO:0019903	protein phosphatase binding	Sirpa	IPI	UniProtKB:P81718	Rat	PMID:16055727|RGD:13792550
Molecular Function	GO:0045309	protein phosphorylated amino acid binding	Sirpa	IPI	PR:Q8K558	Mouse	PMID:12393607
Molecular Function	GO:1990782	protein tyrosine kinase binding	Sirpa	IPI	UniProtKB:Q62689	Rat	PMID:16055727|RGD:13792550
Cellular Component	GO:0009986	cell surface	SIRPA	IDA		Human	PMID:11509594
Cellular Component	GO:0009986	cell surface	Sirpa	IDA		Rat	PMID:21401967|RGD:13792533
Cellular Component	GO:0070062	extracellular exosome	SIRPA	HDA		Human	PMID:19056867
Cellular Component	GO:0005886	plasma membrane	SIRPA	IDA		Human	PMID:24026300
Cellular Component	GO:0005886	plasma membrane	Sirpa	IDA		Mouse	PMID:14634079
Biological Process	GO:0007015	actin filament organization	Sirpa	IMP	MGI:MGI:2388979	Mouse	PMID:11118207
Biological Process	GO:0016477	cell migration	Sirpa	IDA		Rat	PMID:12023387|RGD:625650
Biological Process	GO:0007160	cell-matrix adhesion	Sirpa	IMP	MGI:MGI:2388979	Mouse	PMID:11118207
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Sirpa	IMP		Rat	PMID:16055727|RGD:13792550
Biological Process	GO:0071347	cellular response to interleukin-1	Sirpa	IMP		Rat	PMID:12023387|RGD:625650
Biological Process	GO:0071349	cellular response to interleukin-12	SIRPA	IMP		Human	PMID:11509594
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Sirpa	IDA		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:0071346	cellular response to type II interferon	Sirpa	IMP		Rat	PMID:12023387|RGD:625650
Biological Process	GO:0007010	cytoskeleton organization	Sirpa	IMP	MGI:MGI:2388979	Mouse	PMID:11118207
Biological Process	GO:0097530	granulocyte migration	Sirpa	IGI	UniProtKB:Q62386	Mouse	MGI:MGI:6189453|PMID:24026300
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Sirpa	IMP		Mouse	PMID:24029230
Biological Process	GO:0035696	monocyte extravasation	Sirpa	IMP		Rat	PMID:12023387|RGD:625650
Biological Process	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	Sirpa	IGI	RNAcentral:URS00002075FA_10090	Mouse	MGI:MGI:6189251|PMID:23562609
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:1903720	negative regulation of I-kappaB phosphorylation	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:0050728	negative regulation of inflammatory response	SIRPA	IMP		Human	PMID:24026300
Biological Process	GO:0032688	negative regulation of interferon-beta production	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:0046329	negative regulation of JNK cascade	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:0071641	negative regulation of macrophage inflammatory protein 1 alpha production	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:0050765	negative regulation of phagocytosis	Sirpa	IMP		Mouse	MGI:MGI:6201881|PMID:21401967
Biological Process	GO:0050765	negative regulation of phagocytosis	Sirpa	IMP		Rat	PMID:21401967|RGD:13792533
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Sirpa	IMP		Mouse	MGI:MGI:3760575|PMID:17954568
Biological Process	GO:0006911	phagocytosis, engulfment	Sirpa	IDA		Mouse	PMID:14634079
Biological Process	GO:0006910	phagocytosis, recognition	Sirpa	IDA		Mouse	PMID:14634079
Biological Process	GO:0050766	positive regulation of phagocytosis	Sirpa	IDA		Mouse	PMID:14634079
Biological Process	GO:0010468	regulation of gene expression	SIRPA	IMP		Human	PMID:11509594
Biological Process	GO:0032651	regulation of interleukin-1 beta production	Sirpa	IMP		Rat	PMID:16055727|RGD:13792550
Biological Process	GO:0032675	regulation of interleukin-6 production	Sirpa	IMP		Rat	PMID:16055727|RGD:13792550
Biological Process	GO:0045428	regulation of nitric oxide biosynthetic process	Sirpa	IMP		Rat	PMID:16055727|RGD:13792550
Biological Process	GO:0032680	regulation of tumor necrosis factor production	SIRPA	IGI	UniProtKB:Q08722	Human	PMID:11509594
Biological Process	GO:0032680	regulation of tumor necrosis factor production	Sirpa	IMP		Rat	PMID:16055727|RGD:13792550
Biological Process	GO:0032649	regulation of type II interferon production	SIRPA	IMP		Human	PMID:11509594

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern