Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sirt1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SIRT1
- Mouse genes Sirt1
- Rat genes Sirt1
- Zfish genes sirt1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sirt1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	SIRT1	IPI	UniProtKB:Q14469	Human	PMID:12535671
Molecular Function	GO:0043425	bHLH transcription factor binding	SIRT1	IPI	UniProtKB:Q9UBP5	Human	PMID:12535671
Molecular Function	GO:0043425	bHLH transcription factor binding	SIRT1	IPI	UniProtKB:P01106	Human	PMID:21807113
Molecular Function	GO:0019213	deacetylase activity	SIRT1	IDA		Human	PMID:18203716
Molecular Function	GO:0019213	deacetylase activity	Sirt1	IMP		Mouse	MGI:MGI:3764737\|PMID:18004385
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SIRT1	IPI	UniProtKB:O35426-2	Human	PMID:20955178
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SIRT1	IPI	UniProtKB:P05412	Human	PMID:23382074
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SIRT1	IPI	UniProtKB:P17535	Human	PMID:23382074
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SIRT1	IPI	UniProtKB:P17544	Human	PMID:23382074
Molecular Function	GO:0008047	enzyme activator activity	SIRT1	IDA		Human	PMID:30193097
Molecular Function	GO:0019899	enzyme binding	SIRT1	IPI	UniProtKB:P09874	Human	PMID:23382074
Molecular Function	GO:0019899	enzyme binding	SIRT1	IPI	UniProtKB:Q13492	Human	PMID:23382074
Molecular Function	GO:0019899	enzyme binding	SIRT1	IPI	UniProtKB:Q96PZ0	Human	PMID:23382074
Molecular Function	GO:0019899	enzyme binding	Sirt1	IPI	UniProtKB:Q91YE5	Mouse	MGI:MGI:3852588\|PMID:19578370
Molecular Function	GO:0019899	enzyme binding	Sirt1	IPI	UniProtKB:P04797	Mouse	MGI:MGI:4887284\|PMID:20972425
Molecular Function	GO:0019899	enzyme binding	Sirt1	IPI	RGD:2053	Rat	PMID:19470756\|RGD:8553699
Molecular Function	GO:0019899	enzyme binding	Sirt1	IPI	UniProtKB:P27008	Rat	PMID:19470756\|RGD:8553699
Molecular Function	GO:0004857	enzyme inhibitor activity	SIRT1	IDA		Human	PMID:20100829
Molecular Function	GO:0004857	enzyme inhibitor activity	SIRT1	IDA		Human	PMID:30193097
Molecular Function	GO:0042393	histone binding	SIRT1	IPI	UniProtKB:P10412	Human	PMID:15469825
Molecular Function	GO:0042393	histone binding	SIRT1	IPI	UniProtKB:P16401	Human	PMID:22956909
Molecular Function	GO:0004407	histone deacetylase activity	SIRT1	EXP		Human	PMID:18485871
Molecular Function	GO:0004407	histone deacetylase activity	SIRT1	IDA		Human	PMID:20027304
Molecular Function	GO:0043398	HLH domain binding	SIRT1	IPI	UniProtKB:Q14469	Human	PMID:12535671
Molecular Function	GO:0042802	identical protein binding	SIRT1	IPI	UniProtKB:Q96EB6	Human	PMID:15469825
Molecular Function	GO:1990254	keratin filament binding	SIRT1	IPI	UniProtKB:Q5XKE5	Human	PMID:23382074
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	SIRT1	IPI	UniProtKB:P45983	Human	PMID:20027304
Molecular Function	GO:0140677	molecular function activator activity	SIRT1	IDA		Human	PMID:32538779
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	SIRT1	IDA		Human	PMID:12006491
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	SIRT1	IDA		Human	PMID:15469825
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	SIRT1	IDA		Human	PMID:16079181
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	SIRT1	IDA		Human	PMID:16959573
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	SIRT1	IDA		Human	PMID:28497810
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	Sirt1	IDA		Mouse	PMID:10693811
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	Sirt1	IDA		Rat	PMID:19356683\|RGD:2316170
Molecular Function	GO:0160012	NAD-dependent histone decrotonylase activity	SIRT1	IDA		Human	PMID:28497810
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	Sirt1	IDA		Mouse	MGI:MGI:4887284\|PMID:20972425
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IMP		Human	PMID:11672523
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IDA		Human	PMID:15692560
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IDA		Human	PMID:20100829
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IDA		Human	PMID:20955178
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IDA		Human	PMID:21775285
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IDA		Human	PMID:23142079
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IDA		Human	PMID:29765047
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IDA		Human	PMID:30193097
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IDA		Human	PMID:30409912
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IDA		Human	PMID:32034146
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT1	IDA		Human	PMID:32538779
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt1	IDA		Mouse	MGI:MGI:3579714\|PMID:15716268
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt1	IDA		Mouse	MGI:MGI:6316360\|PMID:16790548
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt1	EXP		Mouse	MGI:MGI:5767074\|PMID:11250901
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt1	IDA		Mouse	MGI:MGI:3813438\|PMID:11672523
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt1	IDA		Mouse	MGI:MGI:5297788\|PMID:15220471
Molecular Function	GO:0016922	nuclear receptor binding	SIRT1	IPI	UniProtKB:Q07869	Human	PMID:24043310
Molecular Function	GO:0002039	p53 binding	SIRT1	IPI	UniProtKB:P04637	Human	PMID:11672523
Molecular Function	GO:0002039	p53 binding	Sirt1	IPI	UniProtKB:P02340	Mouse	MGI:MGI:2152474\|PMID:11672522
Molecular Function	GO:0019212	phosphatase inhibitor activity	SIRT1	IDA		Human	PMID:29765047
Molecular Function	GO:1990841	promoter-specific chromatin binding	Sirt1	IDA		Mouse	PMID:22514318
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P04637	Human	PMID:11672523
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P04637	Human	PMID:12006491
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P29590	Human	PMID:12006491
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q14469	Human	PMID:12535671
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9UBP5	Human	PMID:12535671
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:O43524	Human	PMID:14976264
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:O43524	Human	PMID:15126506
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P98177	Human	PMID:15126506
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q04206	Human	PMID:15152190
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q60974	Human	PMID:15175761
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P04637	Human	PMID:15205477
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P12956	Human	PMID:15205477
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q12778	Human	PMID:15220471
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q09472	Human	PMID:15632193
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q12778	Human	PMID:15692560
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q14192	Human	PMID:15692560
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q01094	Human	PMID:16892051
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:O15350	Human	PMID:16998810
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:O43809	Human	PMID:17172643
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P12956	Human	PMID:17334224
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:O60934	Human	PMID:17612497
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q04724	Human	PMID:17680780
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9Y4H2	Human	PMID:17901049
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q60644	Human	PMID:17936707
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9Z0Y9	Human	PMID:17936707
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P04637	Human	PMID:17964266
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q86WX3	Human	PMID:17964266
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:O43463	Human	PMID:18004385
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q14191	Human	PMID:18203716
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P04637	Human	PMID:18235501
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q12778	Human	PMID:18235501
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q8N163	Human	PMID:18235501
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P04637	Human	PMID:18235502
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q8N163	Human	PMID:18235502
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:O95352	Human	PMID:18296641
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9GZQ8	Human	PMID:18296641
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:O43159	Human	PMID:18485871
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q09472	Human	PMID:19047049
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q01094	Human	PMID:19188449
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q92831	Human	PMID:19188449
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P68400	Human	PMID:19236849
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q13085	Human	PMID:19343720
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q14191	Human	PMID:19343720
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9HAN9	Human	PMID:19478080
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P68400	Human	PMID:19680552
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9NS37	Human	PMID:19690166
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P27695	Human	PMID:19934257
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P10276	Human	PMID:19934264
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q13573	Human	PMID:19934264
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P49815	Human	PMID:20169165
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q15466	Human	PMID:20375098
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:O14640	Human	PMID:20439735
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P68400	Human	PMID:20439735
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q92997	Human	PMID:20439735
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P37231	Human	PMID:20660480
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q09472	Human	PMID:20660480
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P23025	Human	PMID:20670893
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P36956-3	Human	PMID:20817729
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q8N163	Human	PMID:21030595
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q04206	Human	PMID:21081649
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q13043	Human	PMID:21212262
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P27986	Human	PMID:21241768
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9Y4H2	Human	PMID:21241768
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P04637	Human	PMID:21245319
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q8WTS6	Human	PMID:21245319
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P42345	Human	PMID:21471201
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q8N122	Human	PMID:21471201
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q03112	Human	PMID:21555002
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P04198	Human	PMID:21698133
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P31749	Human	PMID:21775285
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P01106	Human	PMID:21807113
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P33076	Human	PMID:21890893
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P51610	Human	PMID:21909281
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P26358	Human	PMID:21947282
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P67870	Human	PMID:21968188
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P68400	Human	PMID:21968188
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P26358	Human	PMID:22094255
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q02577	Human	PMID:22169038
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P04608	Human	PMID:22190034
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9R1E0	Human	PMID:22510882
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P37238	Human	PMID:22863012
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P37238-1	Human	PMID:22863012
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:O75386	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P16220	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P32121	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P43699	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P48594	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:P78316	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q15051	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q16342	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q53H80	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q6NSJ2	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q86U70	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q86WX3	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q8N163	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q96EA4	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9BWG6	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9H0U9	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9NW82	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9NWK9	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9UL40	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9UPT9	Human	PMID:23382074
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q86WX3	Human	PMID:24681097
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q13133	Human	PMID:25661920
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q03164	Human	PMID:25751424
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q86VP3	Human	PMID:29656858
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q86UT8	Human	PMID:31722219
Molecular Function	GO:0005515	protein binding	SIRT1	IPI	UniProtKB:Q9Y5P2	Human	PMID:32761762
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:O54864	Mouse	MGI:MGI:3764737\|PMID:18004385
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:Q64221	Mouse	MGI:MGI:5302137\|PMID:22169038
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:O70343	Mouse	MGI:MGI:3579714\|PMID:15716268
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:P22361	Mouse	MGI:MGI:5315334\|PMID:21176092
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:P06400\|UniProtKB:P28749\|UniProtKB:Q08999	Mouse	MGI:MGI:3761586\|PMID:17620057
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:Q60974	Mouse	MGI:MGI:6092554\|PMID:18829436
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:P81122	Mouse	MGI:MGI:3767135\|PMID:17901049
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:Q12778	Mouse	MGI:MGI:5297788\|PMID:15220471
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:O08785	Mouse	MGI:MGI:3807720\|PMID:18662547
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:Q9R1Y5	Mouse	MGI:MGI:5297787\|PMID:16269335
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:Q01094	Mouse	MGI:MGI:5297785\|PMID:16892051
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:O70343	Mouse	MGI:MGI:3531058\|PMID:15744310
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:O35253	Mouse	MGI:MGI:5306300\|PMID:17098745
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:Q62227	Mouse	MGI:MGI:5014028\|PMID:20375098
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:Q9WTN3	Mouse	MGI:MGI:5315679\|PMID:20817729
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:P37238	Mouse	MGI:MGI:3045940\|PMID:15175761
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:Q9WVH4	Mouse	MGI:MGI:5572869\|PMID:17521387
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:P04637	Mouse	MGI:MGI:3813438\|PMID:11672523
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:O08785	Mouse	MGI:MGI:3807721\|PMID:18662546
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:O08785\|UniProtKB:O54943\|UniProtKB:Q9WTL8	Mouse	MGI:MGI:3807721\|PMID:18662546
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:P04637	Mouse	MGI:MGI:4838949\|PMID:20167603
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:P04637	Mouse	MGI:MGI:4358810\|PMID:19680552
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:Q61214\|UniProtKB:Q922Y0	Mouse	MGI:MGI:4838949\|PMID:20167603
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:P37238	Mouse	MGI:MGI:5438686\|PMID:22863012
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	UniProtKB:Q9WTL8	Mouse	MGI:MGI:3843127\|PMID:19299583
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	PR:Q9R1E0	Mouse	PMID:22514318
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	PR:P41183	Mouse	PMID:23160044
Molecular Function	GO:0005515	protein binding	Sirt1	IPI	PR:P25233	Mouse	PMID:22514318
Molecular Function	GO:0019904	protein domain specific binding	Sirt1	IPI	UniProtKB:Q60974	Mouse	MGI:MGI:3045940\|PMID:15175761
Molecular Function	GO:0043422	protein kinase B binding	Sirt1	IDA		Rat	PMID:23475611\|RGD:9586014
Molecular Function	GO:0033558	protein lysine deacetylase activity	SIRT1	IDA		Human	PMID:19934257
Molecular Function	GO:0033558	protein lysine deacetylase activity	SIRT1	IDA		Human	PMID:20027304
Molecular Function	GO:0033558	protein lysine deacetylase activity	SIRT1	IMP		Human	PMID:20424141
Molecular Function	GO:0033558	protein lysine deacetylase activity	SIRT1	IMP		Human	PMID:20670893
Molecular Function	GO:0033558	protein lysine deacetylase activity	SIRT1	IDA		Human	PMID:21807113
Molecular Function	GO:0033558	protein lysine deacetylase activity	SIRT1	IDA		Human	PMID:23056314
Molecular Function	GO:0033558	protein lysine deacetylase activity	Sirt1	IMP		Mouse	MGI:MGI:5572869\|PMID:17521387
Molecular Function	GO:0033558	protein lysine deacetylase activity	Sirt1	IDA		Mouse	MGI:MGI:3852588\|PMID:19578370
Molecular Function	GO:0033558	protein lysine deacetylase activity	Sirt1	IMP		Mouse	MGI:MGI:5582861\|PMID:24089055
Molecular Function	GO:0033558	protein lysine deacetylase activity	Sirt1	IMP		Mouse	MGI:MGI:4838949\|PMID:20167603
Molecular Function	GO:0106231	protein-propionyllysine depropionylase activity	Sirt1	IMP		Mouse	MGI:MGI:6209006\|PMID:30026585
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Sirt1	IDA		Mouse	MGI:MGI:3843127\|PMID:19299583
Molecular Function	GO:0003713	transcription coactivator activity	Sirt1	IDA		Mouse	MGI:MGI:5810254\|PMID:25526086
Molecular Function	GO:0003714	transcription corepressor activity	SIRT1	IDA		Human	PMID:12535671
Molecular Function	GO:0003714	transcription corepressor activity	Sirt1	IMP		Mouse	MGI:MGI:3045940\|PMID:15175761
Molecular Function	GO:0140537	transcription regulator activator activity	SIRT1	IDA		Human	PMID:23142079
Cellular Component	GO:0030424	axon	Sirt1	IDA		Rat	PMID:23475611\|RGD:9586014
Cellular Component	GO:0000785	chromatin	SIRT1	IDA		Human	PMID:17505061
Cellular Component	GO:0000785	chromatin	SIRT1	IDA		Human	PMID:22956909
Cellular Component	GO:0000785	chromatin	Sirt1	IDA		Mouse	MGI:MGI:5297787\|PMID:16269335
Cellular Component	GO:0005677	chromatin silencing complex	SIRT1	IDA		Human	PMID:18485871
Cellular Component	GO:0005737	cytoplasm	SIRT1	IDA		Human	PMID:20027304
Cellular Component	GO:0005737	cytoplasm	Sirt1	IDA		Mouse	MGI:MGI:3708237\|PMID:17197703
Cellular Component	GO:0005737	cytoplasm	Sirt1	IDA		Mouse	MGI:MGI:4353867\|PMID:19470756
Cellular Component	GO:0005737	cytoplasm	Sirt1	IDA		Mouse	MGI:MGI:5572869\|PMID:17521387
Cellular Component	GO:0005829	cytosol	SIRT1	IDA		Human	PMID:20027304
Cellular Component	GO:0005829	cytosol	SIRT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Sirt1	IDA		Rat	PMID:24183892\|RGD:9495918
Cellular Component	GO:0061773	eNoSc complex	SIRT1	IPI		Human	PMID:18485871
Cellular Component	GO:0000791	euchromatin	SIRT1	IDA		Human	PMID:15469825
Cellular Component	GO:0001650	fibrillar center	SIRT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030426	growth cone	Sirt1	IDA		Rat	PMID:23475611\|RGD:9586014
Cellular Component	GO:0000792	heterochromatin	SIRT1	IDA		Human	PMID:15469825
Cellular Component	GO:0000792	heterochromatin	Sirt1	IDA		Mouse	MGI:MGI:3764737\|PMID:18004385
Cellular Component	GO:0005739	mitochondrion	SIRT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Sirt1	IDA		Mouse	PMID:26767982
Cellular Component	GO:0005635	nuclear envelope	SIRT1	IDA		Human	PMID:15469825
Cellular Component	GO:0005637	nuclear inner membrane	SIRT1	IDA		Human	PMID:15469825
Cellular Component	GO:0005730	nucleolus	SIRT1	IDA		Human	PMID:15469825
Cellular Component	GO:0005730	nucleolus	SIRT1	IDA		Human	PMID:18485871
Cellular Component	GO:0005654	nucleoplasm	SIRT1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SIRT1	IDA		Human	PMID:16079181
Cellular Component	GO:0005634	nucleus	SIRT1	IDA		Human	PMID:11672523
Cellular Component	GO:0005634	nucleus	SIRT1	IDA		Human	PMID:19934257
Cellular Component	GO:0005634	nucleus	SIRT1	IDA		Human	PMID:20027304
Cellular Component	GO:0005634	nucleus	SIRT1	IDA		Human	PMID:20167603
Cellular Component	GO:0005634	nucleus	SIRT1	IDA		Human	PMID:20955178
Cellular Component	GO:0005634	nucleus	Sirt1	IDA		Mouse	MGI:MGI:3807721\|PMID:18662546
Cellular Component	GO:0005634	nucleus	Sirt1	IDA		Mouse	MGI:MGI:3764737\|PMID:18004385
Cellular Component	GO:0005634	nucleus	Sirt1	IDA		Mouse	MGI:MGI:4353867\|PMID:19470756
Cellular Component	GO:0005634	nucleus	Sirt1	IDA		Mouse	PMID:12482959
Cellular Component	GO:0005634	nucleus	Sirt1	IDA		Mouse	PMID:15381699
Cellular Component	GO:0005634	nucleus	Sirt1	IDA		Mouse	PMID:22514318
Cellular Component	GO:0005634	nucleus	Sirt1	IDA		Rat	PMID:20089851\|RGD:2316169
Cellular Component	GO:0005634	nucleus	Sirt1	IDA		Rat	PMID:24183892\|RGD:9495918
Cellular Component	GO:0016605	PML body	SIRT1	IDA		Human	PMID:12006491
Cellular Component	GO:0032991	protein-containing complex	Sirt1	IDA		Mouse	PMID:22514318
Cellular Component	GO:0033553	rDNA heterochromatin	SIRT1	IDA		Human	PMID:18485871
Biological Process	GO:0001525	angiogenesis	SIRT1	IDA		Human	PMID:20620956
Biological Process	GO:0001525	angiogenesis	Sirt1	IMP		Mouse	MGI:MGI:5319292\|PMID:22315447
Biological Process	GO:0042595	behavioral response to starvation	Sirt1	IMP	MGI:MGI:2677369	Mouse	PMID:20668205
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	Sirt1	IMP		Rat	PMID:16207712\|RGD:9495935
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	sirt1	IMP	ZFIN:ZDB-MRPHLNO-080108-2	Zfish	PMID:17938244
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	sirt1	IMP	ZFIN:ZDB-MRPHLNO-080108-1	Zfish	PMID:17938244
Biological Process	GO:1904646	cellular response to amyloid-beta	Sirt1	IEP		Rat	PMID:23555824\|RGD:10047117
Biological Process	GO:1904646	cellular response to amyloid-beta	Sirt1	IMP		Rat	PMID:29358553\|RGD:13838797
Biological Process	GO:0071236	cellular response to antibiotic	Sirt1	IEP		Rat	PMID:17581637\|RGD:2290573
Biological Process	GO:1904644	cellular response to curcumin	Sirt1	IEP		Rat	PMID:24755072\|RGD:10047112
Biological Process	GO:0042149	cellular response to glucose starvation	SIRT1	IMP		Human	PMID:18485871
Biological Process	GO:0070301	cellular response to hydrogen peroxide	SIRT1	IDA		Human	PMID:20027304
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Sirt1	IEP		Rat	PMID:17581637\|RGD:2290573
Biological Process	GO:0071456	cellular response to hypoxia	SIRT1	IMP		Human	PMID:20620956
Biological Process	GO:0071479	cellular response to ionizing radiation	Sirt1	IMP		Mouse	MGI:MGI:5297784\|PMID:17612497
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Sirt1	IEP		Mouse	PMID:20439489
Biological Process	GO:0071407	cellular response to organic cyclic compound	Sirt1	IEP		Rat	PMID:18538940\|RGD:9586004
Biological Process	GO:1904648	cellular response to rotenone	Sirt1	IEP		Rat	PMID:18538940\|RGD:9586004
Biological Process	GO:0009267	cellular response to starvation	Sirt1	IMP		Mouse	MGI:MGI:3045940\|PMID:15175761
Biological Process	GO:0071356	cellular response to tumor necrosis factor	SIRT1	IDA		Human	PMID:15152190
Biological Process	GO:0071303	cellular response to vitamin B3	Sirt1	IEP		Rat	PMID:23555824\|RGD:10047117
Biological Process	GO:0042632	cholesterol homeostasis	Sirt1	IMP		Mouse	MGI:MGI:3790014\|PMID:17936707
Biological Process	GO:0006325	chromatin organization	SIRT1	IMP		Human	PMID:22956909
Biological Process	GO:0032922	circadian regulation of gene expression	SIRT1	IMP		Human	PMID:18662546
Biological Process	GO:0032922	circadian regulation of gene expression	Sirt1	IMP		Mouse	MGI:MGI:3843127\|PMID:19299583
Biological Process	GO:0032922	circadian regulation of gene expression	Sirt1	IMP		Mouse	MGI:MGI:3807721\|PMID:18662546
Biological Process	GO:0007623	circadian rhythm	Sirt1	IEP		Mouse	MGI:MGI:3807721\|PMID:18662546
Biological Process	GO:0006974	DNA damage response	SIRT1	IDA		Human	PMID:18203716
Biological Process	GO:0000731	DNA synthesis involved in DNA repair	Sirt1	IMP		Mouse	MGI:MGI:5297784\|PMID:17612497
Biological Process	GO:0097009	energy homeostasis	SIRT1	IMP		Human	PMID:18485871
Biological Process	GO:0097009	energy homeostasis	Sirt1	IMP		Rat	PMID:24773342\|RGD:9585762
Biological Process	GO:0055089	fatty acid homeostasis	Sirt1	IMP		Mouse	MGI:MGI:3714567\|PMID:17347648
Biological Process	GO:0031507	heterochromatin formation	SIRT1	IDA		Human	PMID:15469825
Biological Process	GO:0031507	heterochromatin formation	Sirt1	IGI	MGI:MGI:107187	Mouse	PMID:23160044
Biological Process	GO:0016575	histone deacetylation	SIRT1	IDA		Human	PMID:12006491
Biological Process	GO:0016575	histone deacetylation	SIRT1	IDA		Human	PMID:15469825
Biological Process	GO:0070932	histone H3 deacetylation	SIRT1	IMP		Human	PMID:17505061
Biological Process	GO:0070932	histone H3 deacetylation	SIRT1	IDA		Human	PMID:20027304
Biological Process	GO:0070932	histone H3 deacetylation	Sirt1	IMP		Rat	PMID:20089851\|RGD:2316169
Biological Process	GO:0001678	intracellular glucose homeostasis	Sirt1	IMP		Mouse	MGI:MGI:3531058\|PMID:15744310
Biological Process	GO:0035356	intracellular triglyceride homeostasis	Sirt1	IMP		Mouse	MGI:MGI:3790014\|PMID:17936707
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Sirt1	IDA		Mouse	MGI:MGI:5297787\|PMID:16269335
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	SIRT1	IMP		Human	PMID:20100829
Biological Process	GO:0033210	leptin-mediated signaling pathway	Sirt1	IMP		Mouse	MGI:MGI:4821191\|PMID:20620997
Biological Process	GO:0030225	macrophage differentiation	Sirt1	IMP		Mouse	MGI:MGI:5319292\|PMID:22315447
Biological Process	GO:0051658	maintenance of nucleus location	SIRT1	IDA		Human	PMID:15692560
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	SIRT1	IMP		Human	PMID:17505061
Biological Process	GO:0043066	negative regulation of apoptotic process	SIRT1	IMP		Human	PMID:16892051
Biological Process	GO:0043066	negative regulation of apoptotic process	SIRT1	IMP		Human	PMID:21775285
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	SIRT1	IDA		Human	PMID:20203304
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Sirt1	IMP		Rat	PMID:20089851\|RGD:2316169
Biological Process	GO:0045786	negative regulation of cell cycle	SIRT1	IMP		Human	PMID:18485871
Biological Process	GO:0030308	negative regulation of cell growth	SIRT1	IMP		Human	PMID:17505061
Biological Process	GO:2000655	negative regulation of cellular response to testosterone stimulus	SIRT1	IMP		Human	PMID:17505061
Biological Process	GO:2000773	negative regulation of cellular senescence	SIRT1	IDA		Human	PMID:20203304
Biological Process	GO:2000773	negative regulation of cellular senescence	SIRT1	IMP		Human	PMID:20424141
Biological Process	GO:0043392	negative regulation of DNA binding	Sirt1	IMP		Rat	PMID:22044919\|RGD:10047123
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	SIRT1	IDA		Human	PMID:11672523
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	SIRT1	IDA		Human	PMID:11672523
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	SIRT1	IMP		Human	PMID:17505061
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	SIRT1	IDA		Human	PMID:20955178
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Sirt1	IMP		Mouse	MGI:MGI:5607229\|PMID:20955178
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	SIRT1	IDA		Human	PMID:11672523
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	SIRT1	IMP		Human	PMID:18485871
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	SIRT1	IDA		Human	PMID:20074560
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sirt1	IDA		Mouse	PMID:15381699
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Sirt1	IMP		Mouse	MGI:MGI:3045940\|PMID:15175761
Biological Process	GO:2000270	negative regulation of fibroblast apoptotic process	Sirt1	IMP		Rat	PMID:23479127\|RGD:9585774
Biological Process	GO:0010629	negative regulation of gene expression	SIRT1	IMP		Human	PMID:17916362
Biological Process	GO:0010629	negative regulation of gene expression	SIRT1	IMP		Human	PMID:20203304
Biological Process	GO:0060125	negative regulation of growth hormone secretion	Sirt1	IMP		Rat	PMID:23292070\|RGD:9585999
Biological Process	GO:0051097	negative regulation of helicase activity	SIRT1	IDA		Human	PMID:18203716
Biological Process	GO:1900113	negative regulation of histone H3-K9 trimethylation	Sirt1	IDA		Mouse	MGI:MGI:5810254\|PMID:25526086
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	SIRT1	IDA		Human	PMID:17680780
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Sirt1	IMP		Mouse	MGI:MGI:2152474\|PMID:11672522
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Sirt1	IGI	MGI:MGI:88276	Mouse	PMID:22956852
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Sirt1	IMP		Rat	PMID:24755072\|RGD:10047112
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Sirt1	IMP		Rat	PMID:29358553\|RGD:13838797
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	SIRT1	IDA		Human	PMID:15152190
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	SIRT1	IMP		Human	PMID:17317627
Biological Process	GO:2000757	negative regulation of peptidyl-lysine acetylation	SIRT1	IDA		Human	PMID:20100829
Biological Process	GO:0042326	negative regulation of phosphorylation	SIRT1	IMP		Human	PMID:17612497
Biological Process	GO:0042326	negative regulation of phosphorylation	Sirt1	IMP		Mouse	MGI:MGI:5297784\|PMID:17612497
Biological Process	GO:0031393	negative regulation of prostaglandin biosynthetic process	Sirt1	IMP		Mouse	MGI:MGI:5306564\|PMID:20042607
Biological Process	GO:1901984	negative regulation of protein acetylation	SIRT1	IMP		Human	PMID:17916362
Biological Process	GO:1901984	negative regulation of protein acetylation	SIRT1	IMP		Human	PMID:20203304
Biological Process	GO:1901984	negative regulation of protein acetylation	Sirt1	IMP		Rat	PMID:22044919\|RGD:10047123
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	SIRT1	IMP		Human	PMID:21149730
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Sirt1	IMP		Mouse	MGI:MGI:5298332\|PMID:21149730
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	Sirt1	IMP		Rat	PMID:22044919\|RGD:10047123
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	Sirt1	IMP		Rat	PMID:23422569\|RGD:9585767
Biological Process	GO:0032007	negative regulation of TOR signaling	SIRT1	IMP		Human	PMID:20169165
Biological Process	GO:0032007	negative regulation of TOR signaling	Sirt1	IMP		Mouse	MGI:MGI:4437499\|PMID:20169165
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SIRT1	IDA		Human	PMID:12535671
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SIRT1	IDA		Human	PMID:15692560
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SIRT1	IDA		Human	PMID:20955178
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SIRT1	IMP		Human	PMID:21947282
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sirt1	IDA		Mouse	MGI:MGI:4353867\|PMID:19470756
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sirt1	IMP		Mouse	MGI:MGI:5607229\|PMID:20955178
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Sirt1	IDA		Mouse	MGI:MGI:5306300\|PMID:17098745
Biological Process	GO:0010868	negative regulation of triglyceride biosynthetic process	SIRT1	IDA		Human	PMID:29765047
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Sirt1	IMP		Rat	PMID:19299582\|RGD:9585771
Biological Process	GO:0051402	neuron apoptotic process	Sirt1	IMP		Rat	PMID:24183892\|RGD:9495918
Biological Process	GO:0001542	ovulation from ovarian follicle	Sirt1	IMP	MGI:MGI:2448246	Mouse	PMID:12482959
Biological Process	GO:0018394	peptidyl-lysine acetylation	SIRT1	IMP		Human	PMID:18004385
Biological Process	GO:0034983	peptidyl-lysine deacetylation	SIRT1	IDA		Human	PMID:15469825
Biological Process	GO:0002821	positive regulation of adaptive immune response	SIRT1	IDA		Human	PMID:21890893
Biological Process	GO:1904179	positive regulation of adipose tissue development	Sirt1	IMP		Mouse	MGI:MGI:5319292\|PMID:22315447
Biological Process	GO:0045766	positive regulation of angiogenesis	SIRT1	IMP		Human	PMID:20424141
Biological Process	GO:0045766	positive regulation of angiogenesis	SIRT1	IDA		Human	PMID:23960241
Biological Process	GO:0045766	positive regulation of angiogenesis	SIRT1	IMP		Human	PMID:24048733
Biological Process	GO:0045766	positive regulation of angiogenesis	SIRT1	IDA		Human	PMID:25217442
Biological Process	GO:0045766	positive regulation of angiogenesis	sirt1	IMP	ZFIN:ZDB-MRPHLNO-180118-1	Zfish	PMID:24940000
Biological Process	GO:0043065	positive regulation of apoptotic process	SIRT1	IDA		Human	PMID:15152190
Biological Process	GO:0043065	positive regulation of apoptotic process	SIRT1	IMP		Human	PMID:19047049
Biological Process	GO:0043065	positive regulation of apoptotic process	Sirt1	IMP		Mouse	MGI:MGI:4838949\|PMID:20167603
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	SIRT1	IDA		Human	PMID:23960241
Biological Process	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	SIRT1	IMP		Human	PMID:18687677
Biological Process	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	Sirt1	IDA		Mouse	MGI:MGI:5306579\|PMID:18687677
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	Sirt1	IMP		Rat	PMID:25281201\|RGD:13514043
Biological Process	GO:0008284	positive regulation of cell population proliferation	SIRT1	IMP		Human	PMID:21807113
Biological Process	GO:2000774	positive regulation of cellular senescence	SIRT1	IDA		Human	PMID:18687677
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Sirt1	IMP		Mouse	MGI:MGI:3790014\|PMID:17936707
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	SIRT1	IMP		Human	PMID:19047049
Biological Process	GO:0045739	positive regulation of DNA repair	SIRT1	IMP		Human	PMID:19934257
Biological Process	GO:2000781	positive regulation of double-strand break repair	SIRT1	IDA		Human	PMID:32538779
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Sirt1	IMP		Mouse	MGI:MGI:5607229\|PMID:20955178
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	SIRT1	IMP		Human	PMID:20203304
Biological Process	GO:0045722	positive regulation of gluconeogenesis	SIRT1	IDA		Human	PMID:15692560
Biological Process	GO:0045722	positive regulation of gluconeogenesis	SIRT1	IDA		Human	PMID:23142079
Biological Process	GO:0045722	positive regulation of gluconeogenesis	SIRT1	IDA		Human	PMID:30193097
Biological Process	GO:0045722	positive regulation of gluconeogenesis	Sirt1	IMP		Mouse	MGI:MGI:5708799\|PMID:26168293
Biological Process	GO:0045722	positive regulation of gluconeogenesis	Sirt1	IMP		Rat	PMID:21212096\|RGD:9585757
Biological Process	GO:0010460	positive regulation of heart rate	Sirt1	IMP		Rat	PMID:22113495\|RGD:7240568
Biological Process	GO:0031065	positive regulation of histone deacetylation	SIRT1	IMP		Human	PMID:18485871
Biological Process	GO:0031062	positive regulation of histone methylation	SIRT1	IMP		Human	PMID:18485871
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	SIRT1	IDA		Human	PMID:21241768
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Sirt1	IMP		Rat	PMID:16366736\|RGD:9585658
Biological Process	GO:0016239	positive regulation of macroautophagy	SIRT1	IDA		Human	PMID:18296641
Biological Process	GO:0016239	positive regulation of macroautophagy	Sirt1	IDA		Mouse	MGI:MGI:3776699\|PMID:18296641
Biological Process	GO:0016239	positive regulation of macroautophagy	Sirt1	IDA		Mouse	MGI:MGI:4940431\|PMID:21189328
Biological Process	GO:2000111	positive regulation of macrophage apoptotic process	Sirt1	IMP		Mouse	MGI:MGI:5306564\|PMID:20042607
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Sirt1	IMP		Mouse	MGI:MGI:5319292\|PMID:22315447
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	SIRT1	IDA		Human	PMID:21890893
Biological Process	GO:0010976	positive regulation of neuron projection development	Sirt1	IMP		Rat	PMID:20434449\|RGD:9585772
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Sirt1	IMP		Mouse	MGI:MGI:4821191\|PMID:20620997
Biological Process	GO:0090312	positive regulation of protein deacetylation	Sirt1	IMP		Rat	PMID:19470756\|RGD:8553699
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Sirt1	IMP		Mouse	MGI:MGI:3767135\|PMID:17901049
Biological Process	GO:0014858	positive regulation of skeletal muscle cell proliferation	Sirt1	IMP		Rat	PMID:18922599\|RGD:9586001
Biological Process	GO:0051152	positive regulation of smooth muscle cell differentiation	Sirt1	IMP		Mouse	MGI:MGI:5810254\|PMID:25526086
Biological Process	GO:2000614	positive regulation of thyroid-stimulating hormone secretion	Sirt1	IMP		Rat	PMID:20668706\|RGD:9585665
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SIRT1	IDA		Human	PMID:12837246
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SIRT1	IDA		Human	PMID:21807113
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sirt1	IDA		Mouse	MGI:MGI:5810254\|PMID:25526086
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Sirt1	IDA		Mouse	MGI:MGI:5297788\|PMID:15220471
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	SIRT1	IMP		Human	PMID:21841822
Biological Process	GO:0006476	protein deacetylation	SIRT1	IMP		Human	PMID:11672523
Biological Process	GO:0006476	protein deacetylation	SIRT1	IDA		Human	PMID:18203716
Biological Process	GO:0006476	protein deacetylation	SIRT1	IDA		Human	PMID:18662546
Biological Process	GO:0006476	protein deacetylation	SIRT1	IDA		Human	PMID:20027304
Biological Process	GO:0006476	protein deacetylation	SIRT1	IDA		Human	PMID:20100829
Biological Process	GO:0006476	protein deacetylation	SIRT1	IMP		Human	PMID:20424141
Biological Process	GO:0006476	protein deacetylation	SIRT1	IDA		Human	PMID:20955178
Biological Process	GO:0006476	protein deacetylation	SIRT1	IMP		Human	PMID:24824780
Biological Process	GO:0006476	protein deacetylation	SIRT1	IDA		Human	PMID:31722219
Biological Process	GO:0006476	protein deacetylation	Sirt1	IDA		Mouse	MGI:MGI:3813438\|PMID:11672523
Biological Process	GO:0006476	protein deacetylation	Sirt1	IMP		Mouse	MGI:MGI:5572869\|PMID:17521387
Biological Process	GO:0006476	protein deacetylation	Sirt1	IMP		Mouse	MGI:MGI:4353867\|PMID:19470756
Biological Process	GO:0006476	protein deacetylation	Sirt1	IMP		Mouse	MGI:MGI:3807721\|PMID:18662546
Biological Process	GO:0006476	protein deacetylation	Sirt1	IDA		Mouse	PMID:22514318
Biological Process	GO:0006476	protein deacetylation	Sirt1	IDA		Rat	PMID:19356683\|RGD:2316170
Biological Process	GO:0106230	protein depropionylation	Sirt1	IDA		Mouse	MGI:MGI:6209006\|PMID:30026585
Biological Process	GO:0031648	protein destabilization	Sirt1	IDA		Mouse	MGI:MGI:3790014\|PMID:17936707
Biological Process	GO:0016567	protein ubiquitination	SIRT1	IMP		Human	PMID:20203304
Biological Process	GO:0016567	protein ubiquitination	SIRT1	IDA		Human	PMID:21841822
Biological Process	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair	SIRT1	IMP		Human	PMID:21149730
Biological Process	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair	Sirt1	IMP		Mouse	MGI:MGI:5298332\|PMID:21149730
Biological Process	GO:0000183	rDNA heterochromatin formation	SIRT1	IDA		Human	PMID:18485871
Biological Process	GO:0000183	rDNA heterochromatin formation	SIRT1	IMP		Human	PMID:18485871
Biological Process	GO:0042981	regulation of apoptotic process	SIRT1	IMP		Human	PMID:19934257
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	Sirt1	IMP		Mouse	MGI:MGI:5014028\|PMID:20375098
Biological Process	GO:0090335	regulation of brown fat cell differentiation	Sirt1	IMP		Mouse	MGI:MGI:4821191\|PMID:20620997
Biological Process	GO:0042127	regulation of cell population proliferation	SIRT1	IMP		Human	PMID:12006491
Biological Process	GO:0010824	regulation of centrosome duplication	SIRT1	IDA		Human	PMID:31722219
Biological Process	GO:0032071	regulation of endodeoxyribonuclease activity	SIRT1	IMP		Human	PMID:19934257
Biological Process	GO:0014013	regulation of gliogenesis	sirt1	IMP	ZFIN:ZDB-MRPHLNO-080108-2	Zfish	PMID:25132384
Biological Process	GO:0014013	regulation of gliogenesis	sirt1	IGI	ZFIN:ZDB-GENE-081203-18	Zfish	PMID:25132384
Biological Process	GO:0010906	regulation of glucose metabolic process	Sirt1	IMP		Mouse	MGI:MGI:3714567\|PMID:17347648
Biological Process	GO:0010883	regulation of lipid storage	Sirt1	IMP		Mouse	MGI:MGI:5319292\|PMID:22315447
Biological Process	GO:0007346	regulation of mitotic cell cycle	SIRT1	IDA		Human	PMID:15692560
Biological Process	GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway	Sirt1	IMP		Mouse	MGI:MGI:3045940\|PMID:15175761
Biological Process	GO:0071900	regulation of protein serine/threonine kinase activity	SIRT1	IMP		Human	PMID:20203304
Biological Process	GO:0034391	regulation of smooth muscle cell apoptotic process	Sirt1	IDA		Mouse	MGI:MGI:5306300\|PMID:17098745
Biological Process	GO:0046015	regulation of transcription by glucose	SIRT1	IMP		Human	PMID:18485871
Biological Process	GO:0045471	response to ethanol	Sirt1	IDA		Rat	PMID:24570955\|RGD:9495922
Biological Process	GO:1902617	response to fluoride	Sirt1	IEP		Rat	PMID:24296261\|RGD:11553819
Biological Process	GO:0042542	response to hydrogen peroxide	SIRT1	IDA		Human	PMID:19934257
Biological Process	GO:0032868	response to insulin	Sirt1	IDA		Mouse	MGI:MGI:3767135\|PMID:17901049
Biological Process	GO:1904373	response to kainic acid	Sirt1	IEP		Rat	PMID:18538940\|RGD:9586004
Biological Process	GO:0044321	response to leptin	Sirt1	IMP		Mouse	MGI:MGI:4821191\|PMID:20620997
Biological Process	GO:0010046	response to mycotoxin	Sirt1	IEP		Rat	PMID:18538940\|RGD:9586004
Biological Process	GO:0031667	response to nutrient levels	Sirt1	IEP		Rat	PMID:15205477\|RGD:1580412
Biological Process	GO:0006979	response to oxidative stress	SIRT1	IDA		Human	PMID:14976264
Biological Process	GO:1904638	response to resveratrol	Sirt1	IEP		Rat	PMID:23555824\|RGD:10047117
Biological Process	GO:1904638	response to resveratrol	Sirt1	IEP		Rat	PMID:23747682\|RGD:10047126
Biological Process	GO:0000012	single strand break repair	SIRT1	IMP		Human	PMID:20097625
Biological Process	GO:0007283	spermatogenesis	Sirt1	IMP	MGI:MGI:2448246	Mouse	PMID:12482959
Biological Process	GO:0090400	stress-induced premature senescence	SIRT1	IMP		Human	PMID:17916362
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	SIRT1	IDA		Human	PMID:23960241
Biological Process	GO:0006642	triglyceride mobilization	Sirt1	IMP		Mouse	MGI:MGI:3045940\|PMID:15175761
Biological Process	GO:0070914	UV-damage excision repair	SIRT1	IMP		Human	PMID:20670893
Biological Process	GO:0001944	vasculature development	sirt1	IMP	ZFIN:ZDB-MRPHLNO-080108-1	Zfish	PMID:17938244
Biological Process	GO:0001944	vasculature development	sirt1	IMP	ZFIN:ZDB-MRPHLNO-080108-2	Zfish	PMID:17938244
Biological Process	GO:0042311	vasodilation	Sirt1	IMP		Rat	PMID:23826814\|RGD:9585662
Biological Process	GO:0050872	white fat cell differentiation	Sirt1	IMP		Mouse	MGI:MGI:3045940\|PMID:15175761

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.