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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sirt2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sirt2
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0048487beta-tubulin bindingSirt2IDAMousePMID:23201684
Molecular FunctionGO:0003682chromatin bindingSIRT2IDAHumanPMID:23908241
Molecular FunctionGO:0140297DNA-binding transcription factor bindingSIRT2IPIUniProtKB:P15172HumanPMID:12887892
Molecular FunctionGO:0140297DNA-binding transcription factor bindingSIRT2IPIUniProtKB:P98177HumanPMID:15126506
Molecular FunctionGO:0035035histone acetyltransferase bindingSIRT2IPIUniProtKB:Q92830HumanPMID:12887892
Molecular FunctionGO:0035035histone acetyltransferase bindingSIRT2IPIUniProtKB:Q92831HumanPMID:12887892
Molecular FunctionGO:0004407histone deacetylase activitySIRT2IDAHumanPMID:17488717
Molecular FunctionGO:0004407histone deacetylase activitySirt2IMPMouseMGI:MGI:5567889|PMID:24334550
Molecular FunctionGO:0042826histone deacetylase bindingSIRT2IPIUniProtKB:Q9UBN7HumanPMID:12620231
Molecular FunctionGO:0003950NAD+ ADP-ribosyltransferase activitySIRT2IDAHumanPMID:10381378
Molecular FunctionGO:0070403NAD+ bindingSIRT2IDAHumanPMID:11427894
Molecular FunctionGO:0017136NAD-dependent histone deacetylase activitySIRT2IDAHumanPMID:11427894
Molecular FunctionGO:0017136NAD-dependent histone deacetylase activitySIRT2IDAHumanPMID:12697818
Molecular FunctionGO:0046970NAD-dependent histone H4K16 deacetylase activitySIRT2IDAHumanPMID:16648462
Molecular FunctionGO:0034979NAD-dependent protein deacetylase activitySIRT2IDAHumanPMID:18722353
Molecular FunctionGO:0034979NAD-dependent protein deacetylase activitySIRT2IDAHumanPMID:21949390
Molecular FunctionGO:0034979NAD-dependent protein deacetylase activitySIRT2IDAHumanPMID:23932781
Molecular FunctionGO:0034979NAD-dependent protein deacetylase activitySIRT2IMPHumanPMID:24681946
Molecular FunctionGO:0034979NAD-dependent protein deacetylase activitySirt2IDARatPMID:17344398|RGD:8553877
Molecular FunctionGO:0140773NAD-dependent protein demyristoylase activitySIRT2IDAHumanPMID:25704306
Molecular FunctionGO:0140773NAD-dependent protein demyristoylase activitySIRT2IDAHumanPMID:32103017
Molecular FunctionGO:0140774NAD-dependent protein depalmitoylase activitySIRT2IDAHumanPMID:32103017
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:O60729HumanPMID:12697818
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:Q92831HumanPMID:12887892
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:P31260HumanPMID:15213244
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:O43809HumanPMID:17172643
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:O14965HumanPMID:17726514
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:Q96GD4HumanPMID:17726514
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:Q09472HumanPMID:18722353
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:Q13547HumanPMID:18722353
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:Q12778HumanPMID:20543840
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:Q04206HumanPMID:21081649
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:Q9BYB0HumanPMID:21653829
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:Q99NH2HumanPMID:21949390
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:P53396HumanPMID:23932781
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:Q16665HumanPMID:24681946
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:P11413HumanPMID:24769394
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:O60566HumanPMID:24825348
Molecular FunctionGO:0005515protein bindingSIRT2IPIUniProtKB:Q9NWD9HumanPMID:27512957
Molecular FunctionGO:0005515protein bindingSirt2IPIUniProtKB:Q9JJ66|UniProtKB:Q9R1K5MouseMGI:MGI:5295303|PMID:22014574
Molecular FunctionGO:0005515protein bindingSirt2IPIUniProtKB:Q9R1E0MouseMGI:MGI:5567909|PMID:19037106
Molecular FunctionGO:0005515protein bindingSirt2IPIUniProtKB:Q9WVH4MouseMGI:MGI:5572869|PMID:17521387
Molecular FunctionGO:0005515protein bindingSirt2IPIUniProtKB:O14965MouseMGI:MGI:5295303|PMID:22014574
Molecular FunctionGO:0033558protein lysine deacetylase activitySIRT2IDAHumanPMID:17172643
Molecular FunctionGO:0033558protein lysine deacetylase activitySIRT2IDAHumanPMID:20543840
Molecular FunctionGO:0033558protein lysine deacetylase activitySIRT2IMPHumanPMID:23908241
Molecular FunctionGO:0033558protein lysine deacetylase activitySirt2IMPMouseMGI:MGI:5572869|PMID:17521387
Molecular FunctionGO:0033558protein lysine deacetylase activitySirt2IMPMouseMGI:MGI:5502462|PMID:23908241
Molecular FunctionGO:0033558protein lysine deacetylase activitySirt2IMPMouseMGI:MGI:5567909|PMID:19037106
Molecular FunctionGO:0033558protein lysine deacetylase activitySirt2IDAMouseMGI:MGI:3770474|PMID:17681146
Molecular FunctionGO:0042903tubulin deacetylase activitySIRT2IDAHumanPMID:12620231
Molecular FunctionGO:0042903tubulin deacetylase activitySIRT2IDAHumanPMID:18722353
Molecular FunctionGO:0042903tubulin deacetylase activitySIRT2IDAHumanPMID:23886946
Molecular FunctionGO:0042903tubulin deacetylase activitySirt2IMPMouseMGI:MGI:5567889|PMID:24334550
Molecular FunctionGO:0042903tubulin deacetylase activitySirt2IDARatPMID:17344398|RGD:8553877
Molecular FunctionGO:0043130ubiquitin bindingSIRT2IDAHumanPMID:12697818
Molecular FunctionGO:0008270zinc ion bindingSIRT2IDAHumanPMID:11427894
Cellular ComponentGO:0005814centrioleSIRT2IDAHumanPMID:17726514
Cellular ComponentGO:0005813centrosomeSIRT2IDAHumanPMID:17488717
Cellular ComponentGO:0005813centrosomeSIRT2IDAHumanPMID:17726514
Cellular ComponentGO:0005694chromosomeSIRT2IDAHumanPMID:16648462
Cellular ComponentGO:0005737cytoplasmSIRT2IDAHumanPMID:12697818
Cellular ComponentGO:0005737cytoplasmSIRT2IDAHumanPMID:15213244
Cellular ComponentGO:0005737cytoplasmSIRT2IDAHumanPMID:16079181
Cellular ComponentGO:0005737cytoplasmSIRT2IDAHumanPMID:16648462
Cellular ComponentGO:0005737cytoplasmSIRT2IDAHumanPMID:17726514
Cellular ComponentGO:0005737cytoplasmSIRT2IDAHumanPMID:20543840
Cellular ComponentGO:0005737cytoplasmSIRT2IDAHumanPMID:23908241
Cellular ComponentGO:0005737cytoplasmSirt2IDAMouseMGI:MGI:5567909|PMID:19037106
Cellular ComponentGO:0005737cytoplasmSirt2IDAMouseMGI:MGI:5572869|PMID:17521387
Cellular ComponentGO:0005737cytoplasmSirt2HDAMouseMGI:MGI:3834050|PMID:17634366
Cellular ComponentGO:0005737cytoplasmSirt2IDAMouseMGI:MGI:5567889|PMID:24334550
Cellular ComponentGO:0005737cytoplasmSirt2IDAMouseMGI:MGI:3770474|PMID:17681146
Cellular ComponentGO:0005737cytoplasmSirt2IDAMousePMID:11056054
Cellular ComponentGO:0005737cytoplasmSirt2IDARatPMID:17344398|RGD:8553877
Cellular ComponentGO:0005829cytosolSIRT2IDAHumanGO_REF:0000052
Cellular ComponentGO:0005829cytosolSIRT2IDAHumanPMID:24681946
Cellular ComponentGO:0097386glial cell projectionSirt2IDARatPMID:17344398|RGD:8553877
Cellular ComponentGO:0098978glutamatergic synapseSirt2EXPRatPMID:28793258|RGD:13702139
Cellular ComponentGO:0098978glutamatergic synapseSirt2IDARatPMID:28793258|RGD:13702139
Cellular ComponentGO:0098978glutamatergic synapseSirt2IMPRatPMID:28793258|RGD:13702139
Cellular ComponentGO:0000792heterochromatinSirt2IDARatPMID:17344398|RGD:8553877
Cellular ComponentGO:0044224juxtaparanode region of axonSirt2IDARatPMID:17344398|RGD:8553877
Cellular ComponentGO:0043219lateral loopSirt2IDARatPMID:21949390|RGD:8655533
Cellular ComponentGO:0072687meiotic spindleSirt2IDAMouseMGI:MGI:5567889|PMID:24334550
Cellular ComponentGO:0005874microtubuleSIRT2IDAHumanPMID:12620231
Cellular ComponentGO:0030496midbodySIRT2IDAHumanPMID:17726514
Cellular ComponentGO:0030496midbodySirt2IDAMouseMGI:MGI:5567889|PMID:24334550
Cellular ComponentGO:0005739mitochondrionSirt2IDAMousePMID:26767982
Cellular ComponentGO:0072686mitotic spindleSIRT2IDAHumanPMID:17488717
Cellular ComponentGO:0043209myelin sheathSirt2HDAMouseMGI:MGI:3834050|PMID:17634366
Cellular ComponentGO:0043209myelin sheathSirt2IDAMouseMGI:MGI:5567913|PMID:16933150
Cellular ComponentGO:0043209myelin sheathSirt2IDARatPMID:17344398|RGD:8553877
Cellular ComponentGO:0043209myelin sheathSirt2IDARatPMID:17960831|RGD:10047364
Cellular ComponentGO:0035748myelin sheath abaxonal regionSirt2IDARatPMID:17344398|RGD:8553877
Cellular ComponentGO:0005730nucleolusSIRT2IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusSIRT2IDAHumanPMID:15213244
Cellular ComponentGO:0005634nucleusSIRT2IDAHumanPMID:16648462
Cellular ComponentGO:0005634nucleusSIRT2IDAHumanPMID:17726514
Cellular ComponentGO:0005634nucleusSIRT2IDAHumanPMID:23908241
Cellular ComponentGO:0005634nucleusSirt2IDAMouseMGI:MGI:5567889|PMID:24334550
Cellular ComponentGO:0005634nucleusSirt2IDAMouseMGI:MGI:5567909|PMID:19037106
Cellular ComponentGO:0005634nucleusSirt2IDARatPMID:22078938|RGD:9586048
Cellular ComponentGO:0033010paranodal junctionSirt2IDAMouseMGI:MGI:5567913|PMID:16933150
Cellular ComponentGO:0033010paranodal junctionSirt2IDARatPMID:17344398|RGD:8553877
Cellular ComponentGO:0033010paranodal junctionSirt2IDARatPMID:21949390|RGD:8655533
Cellular ComponentGO:0033270paranode region of axonSirt2IDARatPMID:17344398|RGD:8553877
Cellular ComponentGO:0043204perikaryonSirt2IDAMouseMGI:MGI:5567913|PMID:16933150
Cellular ComponentGO:0043204perikaryonSirt2IDARatPMID:17344398|RGD:8553877
Cellular ComponentGO:0048471perinuclear region of cytoplasmSirt2IDAMouseMGI:MGI:5567913|PMID:16933150
Cellular ComponentGO:0005886plasma membraneSIRT2IDAHumanGO_REF:0000052
Cellular ComponentGO:0043220Schmidt-Lanterman incisureSirt2IDAMouseMGI:MGI:5567913|PMID:16933150
Cellular ComponentGO:0043220Schmidt-Lanterman incisureSirt2IDARatPMID:21949390|RGD:8655533
Cellular ComponentGO:0005819spindleSIRT2IDAHumanPMID:17726514
Cellular ComponentGO:0097456terminal loopSirt2IDARatPMID:17344398|RGD:8553877
Biological ProcessGO:0044242cellular lipid catabolic processSirt2IMPMouseMGI:MGI:5567909|PMID:19037106
Biological ProcessGO:0061433cellular response to caloric restrictionSirt2IDAMouseMGI:MGI:5572869|PMID:17521387
Biological ProcessGO:0071872cellular response to epinephrine stimulusSirt2IDAMouseMGI:MGI:5567909|PMID:19037106
Biological ProcessGO:0071456cellular response to hypoxiaSIRT2IDAHumanPMID:24681946
Biological ProcessGO:0034599cellular response to oxidative stressSirt2IDAMouseMGI:MGI:5572869|PMID:17521387
Biological ProcessGO:0007417central nervous system developmentSirt2IEPRatPMID:17344398|RGD:8553877
Biological ProcessGO:0006325chromatin organizationSirt2IGIMGI:MGI:2144471MousePMID:20562830
Biological ProcessGO:0006325chromatin organizationSirt2IGIMGI:MGI:1915724MousePMID:20562830
Biological ProcessGO:0060271cilium assemblysirt2IMPZFIN:ZDB-MRPHLNO-150911-3ZfishPMID:24203696
Biological ProcessGO:0060271cilium assemblysirt2IMPZFIN:ZDB-MRPHLNO-150911-2ZfishPMID:24203696
Biological ProcessGO:0040029epigenetic regulation of gene expressionSIRT2IMPHumanPMID:23908241
Biological ProcessGO:0040029epigenetic regulation of gene expressionSirt2IMPMouseMGI:MGI:5502462|PMID:23908241
Biological ProcessGO:0030097hemopoiesissirt2IMPZFIN:ZDB-MRPHLNO-150911-2ZfishPMID:31366618
Biological ProcessGO:0070933histone H4 deacetylationSIRT2IDAHumanPMID:16648462
Biological ProcessGO:0070933histone H4 deacetylationSIRT2IDAHumanPMID:17488717
Biological ProcessGO:0022011myelination in peripheral nervous systemSirt2IMPMouseMGI:MGI:5295137|PMID:21949390
Biological ProcessGO:0022011myelination in peripheral nervous systemSirt2IMPRatPMID:21949390|RGD:8655533
Biological ProcessGO:0016525negative regulation of angiogenesissirt2IMPZFIN:ZDB-MRPHLNO-180118-3ZfishPMID:24940000
Biological ProcessGO:0043066negative regulation of apoptotic processSirt2IMPRatPMID:23522375|RGD:9586035
Biological ProcessGO:0010507negative regulation of autophagySIRT2IMPHumanPMID:20543840
Biological ProcessGO:0008285negative regulation of cell population proliferationSIRT2IMPHumanPMID:17488717
Biological ProcessGO:0008285negative regulation of cell population proliferationSirt2IMPMouseMGI:MGI:5574427|PMID:24681946
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionSIRT2IDAHumanPMID:12887892
Biological ProcessGO:0045599negative regulation of fat cell differentiationSirt2IMPMouseMGI:MGI:5567909|PMID:19037106
Biological ProcessGO:0045599negative regulation of fat cell differentiationSirt2IMPMouseMGI:MGI:3770474|PMID:17681146
Biological ProcessGO:1900226negative regulation of NLRP3 inflammasome complex assemblySirt2IMPMousePMID:23502856
Biological ProcessGO:0048715negative regulation of oligodendrocyte differentiationSirt2IMPRatPMID:17344398|RGD:8553877
Biological ProcessGO:0070446negative regulation of oligodendrocyte progenitor proliferationSirt2IMPRatPMID:17344398|RGD:8553877
Biological ProcessGO:0010801negative regulation of peptidyl-threonine phosphorylationSirt2IMPMouseMGI:MGI:5295137|PMID:21949390
Biological ProcessGO:0042177negative regulation of protein catabolic processSIRT2IMPHumanPMID:20543840
Biological ProcessGO:2000378negative regulation of reactive oxygen species metabolic processSirt2IMPMouseMGI:MGI:5572869|PMID:17521387
Biological ProcessGO:0045843negative regulation of striated muscle tissue developmentSIRT2IDAHumanPMID:12887892
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IISIRT2IDAHumanPMID:18722353
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IISirt2IMPMouseMGI:MGI:5574427|PMID:24681946
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IISirt2IMPMouseMGI:MGI:5567909|PMID:19037106
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IISirt2IMPMouseMGI:MGI:3770474|PMID:17681146
Biological ProcessGO:0061428negative regulation of transcription from RNA polymerase II promoter in response to hypoxiaSIRT2IMPHumanPMID:24681946
Biological ProcessGO:0044546NLRP3 inflammasome complex assemblySirt2IMPMousePMID:23502856
Biological ProcessGO:0034983peptidyl-lysine deacetylationSIRT2IDAHumanPMID:23932781
Biological ProcessGO:0051987positive regulation of attachment of spindle microtubules to kinetochoreSirt2IMPMouseMGI:MGI:5567889|PMID:24334550
Biological ProcessGO:0051781positive regulation of cell divisionSirt2IMPMouseMGI:MGI:5567889|PMID:24334550
Biological ProcessGO:0043388positive regulation of DNA bindingSirt2IDAMouseMGI:MGI:5572869|PMID:17521387
Biological ProcessGO:1900119positive regulation of execution phase of apoptosisSirt2IMPMouseMGI:MGI:5572869|PMID:17521387
Biological ProcessGO:0045723positive regulation of fatty acid biosynthetic processSIRT2IDAHumanPMID:23932781
Biological ProcessGO:0045836positive regulation of meiotic nuclear divisionSirt2IMPMouseMGI:MGI:5567889|PMID:24334550
Biological ProcessGO:1900195positive regulation of oocyte maturationSirt2IMPMouseMGI:MGI:5567889|PMID:24334550
Biological ProcessGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processSirt2IMPMouseMGI:MGI:5574427|PMID:24681946
Biological ProcessGO:2000777positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaSIRT2IMPHumanPMID:24681946
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISirt2IMPMouseMGI:MGI:5572869|PMID:17521387
Biological ProcessGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic processSIRT2IMPHumanPMID:21841822
Biological ProcessGO:0006476protein deacetylationSIRT2IDAHumanPMID:20543840
Biological ProcessGO:0006476protein deacetylationSIRT2IDAHumanPMID:21949390
Biological ProcessGO:0006476protein deacetylationSIRT2IMPHumanPMID:24681946
Biological ProcessGO:0006476protein deacetylationSirt2IMPMouseMGI:MGI:5567909|PMID:19037106
Biological ProcessGO:0006476protein deacetylationSirt2IMPMouseMGI:MGI:5295137|PMID:21949390
Biological ProcessGO:0006476protein deacetylationSirt2IDAMouseMGI:MGI:3770474|PMID:17681146
Biological ProcessGO:0006476protein deacetylationSirt2IMPMouseMGI:MGI:5572869|PMID:17521387
Biological ProcessGO:0006476protein deacetylationSirt2IMPMGI:MGI:4441346MousePMID:30655546
Biological ProcessGO:0006476protein deacetylationSirt2IMPRatPMID:21949390|RGD:8655533
Biological ProcessGO:0051726regulation of cell cycleSIRT2IMPHumanPMID:17726514
Biological ProcessGO:0045598regulation of fat cell differentiationSirt2IMPMousePMID:23126280
Biological ProcessGO:0031641regulation of myelinationSirt2IMPMouseMGI:MGI:5295137|PMID:21949390
Biological ProcessGO:0031641regulation of myelinationSirt2IMPRatPMID:21949390|RGD:8655533
Biological ProcessGO:0099149regulation of postsynaptic neurotransmitter receptor internalizationSirt2EXPRatPMID:28793258|RGD:13702139
Biological ProcessGO:0099149regulation of postsynaptic neurotransmitter receptor internalizationSirt2IDARatPMID:28793258|RGD:13702139
Biological ProcessGO:0099149regulation of postsynaptic neurotransmitter receptor internalizationSirt2IEPRatPMID:28793258|RGD:13702139
Biological ProcessGO:0099149regulation of postsynaptic neurotransmitter receptor internalizationSirt2IMPRatPMID:28793258|RGD:13702139
Biological ProcessGO:0021762substantia nigra developmentSIRT2HEPHumanPMID:22926577
Biological ProcessGO:0090042tubulin deacetylationSIRT2IDAHumanPMID:18722353
Biological ProcessGO:0090042tubulin deacetylationSIRT2IDAHumanPMID:23886946
Biological ProcessGO:0090042tubulin deacetylationSIRT2IMPHumanPMID:24681946
Biological ProcessGO:0090042tubulin deacetylationSirt2IGIMGI:MGI:2144471MousePMID:20562830
Biological ProcessGO:0090042tubulin deacetylationSirt2IGIMGI:MGI:1915724MousePMID:20562830
Biological ProcessGO:0090042tubulin deacetylationSirt2IMPMousePMID:23126280
Biological ProcessGO:0090042tubulin deacetylationSirt2IMPMousePMID:23502856
Biological ProcessGO:0090042tubulin deacetylationSirt2IDARatPMID:17344398|RGD:8553877

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
08/02/2024
MGI 6.24
The Jackson Laboratory