Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIRT3
  • Mouse genes Sirt3
  • Rat genes Sirt3
  • Zfish genes sirt3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sirt3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008047	enzyme activator activity	Sirt3	IDA		Mouse	PMID:21858060
Molecular Function	GO:0019899	enzyme binding	Sirt3	IPI	RGD:3732	Rat	PMID:24505357|RGD:8158103
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt3	IDA		Mouse	MGI:MGI:5755322|PMID:26620563
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt3	IDA		Mouse	MGI:MGI:6316360|PMID:16790548
Molecular Function	GO:0005515	protein binding	SIRT3	IPI	UniProtKB:Q9NUB1	Human	PMID:16788062
Molecular Function	GO:0005515	protein binding	SIRT3	IPI	UniProtKB:P25705	Human	PMID:19343720
Molecular Function	GO:0005515	protein binding	SIRT3	IPI	UniProtKB:Q9NUB1	Human	PMID:19535340
Molecular Function	GO:0005515	protein binding	SIRT3	IPI	UniProtKB:Q13309	Human	PMID:22770219
Molecular Function	GO:0005515	protein binding	SIRT3	IPI	UniProtKB:O00411,UniProtKB:O43524	Human	PMID:23283301
Molecular Function	GO:0005515	protein binding	SIRT3	IPI	UniProtKB:O60313	Human	PMID:24344202
Molecular Function	GO:0005515	protein binding	SIRT3	IPI	UniProtKB:O00411,UniProtKB:O43524,UniProtKB:Q00059	Human	PMID:29445193
Molecular Function	GO:0005515	protein binding	SIRT3	IPI	UniProtKB:P28799-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Sirt3	IPI	UniProtKB:P27545|UniProtKB:Q8C172|UniProtKB:Q924Z4	Mouse	MGI:MGI:5755322|PMID:26620563
Molecular Function	GO:0005515	protein binding	Sirt3	IPI	UniProtKB:Q8BKF1,UniProtKB:Q9WVH4	Mouse	MGI:MGI:6120139|PMID:23283301
Molecular Function	GO:0005515	protein binding	Sirt3	IPI	UniProtKB:P47738	Mouse	MGI:MGI:5141159|PMID:21720390
Molecular Function	GO:0033558	protein lysine deacetylase activity	Sirt3	IDA		Mouse	PMID:21858060
Molecular Function	GO:0043565	sequence-specific DNA binding	SIRT3	IDA		Human	PMID:29445193
Molecular Function	GO:0043565	sequence-specific DNA binding	Sirt3	IDA		Mouse	MGI:MGI:6120139|PMID:23283301
Molecular Function	GO:0008270	zinc ion binding	SIRT3	IDA		Human	PMID:19535340
Cellular Component	GO:0016020	membrane	Sirt3	IDA		Mouse	PMID:11056054
Cellular Component	GO:0005743	mitochondrial inner membrane	Sirt3	IDA		Mouse	MGI:MGI:3771675|PMID:18054327
Cellular Component	GO:0005759	mitochondrial matrix	SIRT3	IDA		Human	PMID:29445193
Cellular Component	GO:0005759	mitochondrial matrix	SIRT3	IDA		Human	PMID:12186850
Cellular Component	GO:0005759	mitochondrial matrix	Sirt3	IDA		Mouse	PMID:17923681
Cellular Component	GO:0005739	mitochondrion	SIRT3	IDA		Human	PMID:16079181
Cellular Component	GO:0005739	mitochondrion	Sirt3	IDA		Mouse	PMID:17923681
Cellular Component	GO:0005739	mitochondrion	Sirt3	IDA		Mouse	PMID:26767982
Cellular Component	GO:0005739	mitochondrion	Sirt3	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Sirt3	IDA		Rat	PMID:22078938|RGD:9586048
Cellular Component	GO:0032991	protein-containing complex	SIRT3	IDA		Human	PMID:23283301
Cellular Component	GO:0032991	protein-containing complex	SIRT3	IDA		Human	PMID:29445193
Cellular Component	GO:0032991	protein-containing complex	Sirt3	IDA		Mouse	MGI:MGI:6120139|PMID:23283301
Biological Process	GO:0009060	aerobic respiration	SIRT3	IMP		Human	PMID:22309213
Biological Process	GO:0007568	aging	Sirt3	IEP		Rat	PMID:24505357|RGD:8158103
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Sirt3	IMP		Rat	PMID:23397292|RGD:9586042
Biological Process	GO:2000757	negative regulation of peptidyl-lysine acetylation	Sirt3	IDA		Mouse	PMID:17923681
Biological Process	GO:2000757	negative regulation of peptidyl-lysine acetylation	Sirt3	IMP	MGI:MGI:3769234	Mouse	PMID:17923681
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	Sirt3	IMP		Rat	PMID:23397292|RGD:9586042
Biological Process	GO:0034983	peptidyl-lysine deacetylation	SIRT3	IMP		Human	PMID:22309213
Biological Process	GO:0034983	peptidyl-lysine deacetylation	Sirt3	IDA		Mouse	MGI:MGI:5755322|PMID:26620563
Biological Process	GO:1902553	positive regulation of catalase activity	SIRT3	IDA		Human	PMID:25210848
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	Sirt3	IDA		Mouse	MGI:MGI:5755322|PMID:26620563
Biological Process	GO:0032024	positive regulation of insulin secretion	Sirt3	IMP		Rat	PMID:23397292|RGD:9586042
Biological Process	GO:1903109	positive regulation of mitochondrial transcription	Sirt3	IMP		Mouse	MGI:MGI:6120139|PMID:23283301
Biological Process	GO:1901671	positive regulation of superoxide dismutase activity	SIRT3	IDA		Human	PMID:25210848
Biological Process	GO:0006476	protein deacetylation	SIRT3	IDA		Human	PMID:16788062
Biological Process	GO:0006476	protein deacetylation	Sirt3	IMP	MGI:MGI:3769234	Mouse	PMID:23576753

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern