Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIRT4
  • Mouse genes Sirt4
  • Rat genes Sirt4
  • Zfish genes sirt4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sirt4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061690	lipoamidase activity	Sirt4	IMP		Mouse	MGI:MGI:5619880|PMID:25525879
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	SIRT4	IDA		Human	PMID:16959573
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	SIRT4	IDA		Human	PMID:17715127
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	Sirt4	IMP		Mouse	MGI:MGI:5499916|PMID:23663782
Molecular Function	GO:0106420	NAD-dependent protein biotinidase activity	SIRT4	IDA		Human	PMID:25525879
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt4	IDA		Mouse	MGI:MGI:5501374|PMID:23746352
Molecular Function	GO:0106419	NAD-dependent protein lipoamidase activity	SIRT4	IDA		Human	PMID:25525879
Molecular Function	GO:0005515	protein binding	SIRT4	IPI	UniProtKB:P00367	Human	PMID:16959573
Molecular Function	GO:0005515	protein binding	SIRT4	IPI	UniProtKB:P05141	Human	PMID:17715127
Molecular Function	GO:0005515	protein binding	SIRT4	IPI	UniProtKB:P14735	Human	PMID:17715127
Molecular Function	GO:0005515	protein binding	SIRT4	IPI	UniProtKB:O00330	Human	PMID:25525879
Molecular Function	GO:0005515	protein binding	SIRT4	IPI	UniProtKB:P10515	Human	PMID:25525879
Molecular Function	GO:0005515	protein binding	Sirt4	IPI	UniProtKB:Q99J39	Mouse	MGI:MGI:5501374|PMID:23746352
Molecular Function	GO:0005515	protein binding	Sirt4	IPI	PR:P26443	Mouse	PMID:16959573
Cellular Component	GO:0005743	mitochondrial inner membrane	Sirt4	IDA		Mouse	MGI:MGI:3771675|PMID:18054327
Cellular Component	GO:0005759	mitochondrial matrix	SIRT4	IDA		Human	PMID:16959573
Cellular Component	GO:0005759	mitochondrial matrix	SIRT4	IDA		Human	PMID:17715127
Cellular Component	GO:0005759	mitochondrial matrix	Sirt4	IDA		Mouse	MGI:MGI:5501374|PMID:23746352
Cellular Component	GO:0005739	mitochondrion	SIRT4	IDA		Human	PMID:16079181
Cellular Component	GO:0005739	mitochondrion	Sirt4	IDA		Mouse	PMID:16959573
Cellular Component	GO:0005739	mitochondrion	Sirt4	IDA		Mouse	PMID:17923681
Cellular Component	GO:0005739	mitochondrion	Sirt4	IDA		Mouse	PMID:26767982
Cellular Component	GO:0005739	mitochondrion	Sirt4	IDA		Rat	PMID:23281078|RGD:9586051
Biological Process	GO:0071456	cellular response to hypoxia	Sirt4	IEP		Rat	PMID:24029877|RGD:9586053
Biological Process	GO:0006974	DNA damage response	Sirt4	IDA		Mouse	MGI:MGI:5490691|PMID:23562301
Biological Process	GO:0006541	glutamine metabolic process	Sirt4	IMP		Mouse	MGI:MGI:5490691|PMID:23562301
Biological Process	GO:0006541	glutamine metabolic process	Sirt4	IMP		Mouse	MGI:MGI:5499916|PMID:23663782
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Sirt4	IMP		Rat	PMID:24029877|RGD:9586053
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	SIRT4	IMP		Human	PMID:24043310
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	Sirt4	IDA		Mouse	MGI:MGI:5501374|PMID:23746352
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	Sirt4	IMP		Mouse	MGI:MGI:5547879|PMID:24043310
Biological Process	GO:0046676	negative regulation of insulin secretion	SIRT4	IMP		Human	PMID:17715127
Biological Process	GO:0046676	negative regulation of insulin secretion	Sirt4	IGI	MGI:MGI:95753	Mouse	PMID:16959573
Biological Process	GO:0046676	negative regulation of insulin secretion	Sirt4	IMP	MGI:MGI:3769237	Mouse	PMID:16959573
Biological Process	GO:1903217	negative regulation of protein processing involved in protein targeting to mitochondrion	Sirt4	IMP		Rat	PMID:24029877|RGD:9586053
Biological Process	GO:0034983	peptidyl-lysine deacetylation	Sirt4	IDA		Mouse	MGI:MGI:5501374|PMID:23746352
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	Sirt4	IDA		Mouse	MGI:MGI:5501374|PMID:23746352
Biological Process	GO:0000820	regulation of glutamine family amino acid metabolic process	Sirt4	IMP		Mouse	MGI:MGI:5490691|PMID:23562301
Biological Process	GO:1904182	regulation of pyruvate dehydrogenase activity	SIRT4	IDA		Human	PMID:25525879
Biological Process	GO:1904182	regulation of pyruvate dehydrogenase activity	Sirt4	IMP		Mouse	MGI:MGI:5619880|PMID:25525879
Biological Process	GO:0072350	tricarboxylic acid metabolic process	Sirt4	IMP		Mouse	MGI:MGI:5499916|PMID:23663782
Biological Process	GO:0072350	tricarboxylic acid metabolic process	Sirt4	IMP		Mouse	MGI:MGI:5490691|PMID:23562301

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern