Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIRT5
  • Mouse genes Sirt5
  • Rat genes Sirt5
  • Zfish genes sirt5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sirt5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000035	acyl binding	sirt5	IDA		Zfish	PMID:29044784
Molecular Function	GO:1901363	heterocyclic compound binding	sirt5	IDA		Zfish	PMID:29044784
Molecular Function	GO:0070403	NAD+ binding	SIRT5	IDA		Human	PMID:21908771
Molecular Function	GO:0070403	NAD+ binding	SIRT5	IDA		Human	PMID:22076378
Molecular Function	GO:0005515	protein binding	Sirt5	IPI	UniProtKB:Q8C196	Mouse	MGI:MGI:3846470|PMID:19410549
Molecular Function	GO:0061697	protein-glutaryllysine deglutarylase activity	SIRT5	IDA		Human	PMID:24703693
Molecular Function	GO:0061697	protein-glutaryllysine deglutarylase activity	Sirt5	IDA		Mouse	MGI:MGI:5582979|PMID:24703693
Molecular Function	GO:0036054	protein-malonyllysine demalonylase activity	SIRT5	IDA		Human	PMID:21908771
Molecular Function	GO:0036054	protein-malonyllysine demalonylase activity	SIRT5	IDA		Human	PMID:22076378
Molecular Function	GO:0036054	protein-malonyllysine demalonylase activity	SIRT5	IDA		Human	PMID:24703693
Molecular Function	GO:0036054	protein-malonyllysine demalonylase activity	Sirt5	IMP		Mouse	MGI:MGI:5306729|PMID:21908771
Molecular Function	GO:0036054	protein-malonyllysine demalonylase activity	Sirt5	IDA		Mouse	MGI:MGI:5582979|PMID:24703693
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	SIRT5	IDA		Human	PMID:21908771
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	SIRT5	IDA		Human	PMID:22076378
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	SIRT5	IDA		Human	PMID:24140062
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	SIRT5	IDA		Human	PMID:24703693
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	SIRT5	IDA		Human	PMID:29180469
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	Sirt5	IMP		Mouse	MGI:MGI:5527057|PMID:23806337
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	Sirt5	IDA		Mouse	MGI:MGI:5582979|PMID:24703693
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	Sirt5	IMP		Mouse	MGI:MGI:5306729|PMID:21908771
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	Sirt5	IMP		Mouse	MGI:MGI:5296381|PMID:22076378
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	Sirt5	IMP		Mouse	MGI:MGI:5547422|PMID:24315375
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	Sirt5	IMP	MGI:MGI:5297911	Mouse	PMID:26388266
Molecular Function	GO:0008270	zinc ion binding	SIRT5	IDA		Human	PMID:22076378
Cellular Component	GO:0005829	cytosol	SIRT5	IDA		Human	PMID:23806337
Cellular Component	GO:0005829	cytosol	Sirt5	IDA		Mouse	MGI:MGI:5527057|PMID:23806337
Cellular Component	GO:0005743	mitochondrial inner membrane	Sirt5	IDA		Mouse	MGI:MGI:3771675|PMID:18054327
Cellular Component	GO:0005758	mitochondrial intermembrane space	SIRT5	IDA		Human	PMID:18680753
Cellular Component	GO:0005759	mitochondrial matrix	SIRT5	IDA		Human	PMID:18680753
Cellular Component	GO:0005739	mitochondrion	SIRT5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	SIRT5	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005739	mitochondrion	SIRT5	IDA		Human	PMID:16079181
Cellular Component	GO:0005739	mitochondrion	SIRT5	IDA		Human	PMID:23806337
Cellular Component	GO:0005739	mitochondrion	Sirt5	IDA		Mouse	MGI:MGI:5527057|PMID:23806337
Cellular Component	GO:0005739	mitochondrion	Sirt5	IDA		Mouse	PMID:17923681
Cellular Component	GO:0005739	mitochondrion	Sirt5	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Sirt5	IMP	MGI:MGI:5297911	Mouse	PMID:26388266
Cellular Component	GO:0005739	mitochondrion	Sirt5	IDA		Mouse	PMID:26388266
Cellular Component	GO:0005739	mitochondrion	Sirt5	IDA		Mouse	PMID:26767982
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Sirt5	IMP		Rat	PMID:24192575|RGD:9586058
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	SIRT5	IDA		Human	PMID:24140062
Biological Process	GO:0036047	peptidyl-lysine demalonylation	SIRT5	IDA		Human	PMID:21908771
Biological Process	GO:0036047	peptidyl-lysine demalonylation	SIRT5	IDA		Human	PMID:22076378
Biological Process	GO:0036047	peptidyl-lysine demalonylation	Sirt5	IMP		Mouse	MGI:MGI:5306729|PMID:21908771
Biological Process	GO:0036049	peptidyl-lysine desuccinylation	SIRT5	IDA		Human	PMID:21908771
Biological Process	GO:0036049	peptidyl-lysine desuccinylation	SIRT5	IDA		Human	PMID:22076378
Biological Process	GO:0036049	peptidyl-lysine desuccinylation	Sirt5	IMP		Mouse	MGI:MGI:5296381|PMID:22076378
Biological Process	GO:0036049	peptidyl-lysine desuccinylation	Sirt5	IMP		Mouse	MGI:MGI:5306729|PMID:21908771
Biological Process	GO:0036049	peptidyl-lysine desuccinylation	Sirt5	IMP	MGI:MGI:5297911	Mouse	PMID:26388266
Biological Process	GO:0006476	protein deacetylation	SIRT5	IDA		Human	PMID:18680753
Biological Process	GO:0061698	protein deglutarylation	SIRT5	IDA		Human	PMID:24703693
Biological Process	GO:0061698	protein deglutarylation	Sirt5	IDA		Mouse	MGI:MGI:5582979|PMID:24703693
Biological Process	GO:0036046	protein demalonylation	SIRT5	IDA		Human	PMID:24703693
Biological Process	GO:0036046	protein demalonylation	Sirt5	IDA		Mouse	MGI:MGI:5582979|PMID:24703693
Biological Process	GO:0036048	protein desuccinylation	SIRT5	IDA		Human	PMID:24140062
Biological Process	GO:0036048	protein desuccinylation	SIRT5	IDA		Human	PMID:24703693
Biological Process	GO:0036048	protein desuccinylation	SIRT5	IDA		Human	PMID:29180469
Biological Process	GO:0036048	protein desuccinylation	Sirt5	IMP		Mouse	MGI:MGI:5527057|PMID:23806337
Biological Process	GO:0036048	protein desuccinylation	Sirt5	IDA		Mouse	MGI:MGI:5582979|PMID:24703693
Biological Process	GO:0036048	protein desuccinylation	Sirt5	IMP		Mouse	MGI:MGI:5547422|PMID:24315375
Biological Process	GO:0010566	regulation of ketone biosynthetic process	Sirt5	IMP		Mouse	MGI:MGI:5547422|PMID:24315375
Biological Process	GO:1904229	regulation of succinate dehydrogenase activity	Sirt5	IMP	MGI:MGI:5297911	Mouse	PMID:26388266
Biological Process	GO:0002931	response to ischemia	Sirt5	IMP	MGI:MGI:5297911	Mouse	PMID:26388266
Biological Process	GO:0031667	response to nutrient levels	Sirt5	IEP		Rat	PMID:21826711|RGD:9586056

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern