Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Sirt6

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SIRT6
- Mouse genes Sirt6
- Rat genes Sirt6
- Zfish genes sirt6
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sirt6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	SIRT6	IDA		Human	PMID:27043296
Molecular Function	GO:0003682	chromatin binding	SIRT6	IDA		Human	PMID:27912097
Molecular Function	GO:0003682	chromatin binding	Sirt6	IDA		Mouse	PMID:24105743
Molecular Function	GO:0031490	chromatin DNA binding	SIRT6	IDA		Human	PMID:33067423
Molecular Function	GO:0003684	damaged DNA binding	SIRT6	IDA		Human	PMID:31995034
Molecular Function	GO:0003684	damaged DNA binding	SIRT6	IDA		Human	PMID:32538779
Molecular Function	GO:0140612	DNA damage sensor activity	SIRT6	IDA		Human	PMID:31995034
Molecular Function	GO:0140612	DNA damage sensor activity	SIRT6	IDA		Human	PMID:32538779
Molecular Function	GO:0008047	enzyme activator activity	SIRT6	IDA		Human	PMID:23892288
Molecular Function	GO:0008047	enzyme activator activity	SIRT6	IDA		Human	PMID:27043296
Molecular Function	GO:0008047	enzyme activator activity	SIRT6	IDA		Human	PMID:31995034
Molecular Function	GO:0008047	enzyme activator activity	SIRT6	IDA		Human	PMID:32538779
Molecular Function	GO:0008047	enzyme activator activity	SIRT6	IDA		Human	PMID:33067423
Molecular Function	GO:0035033	histone deacetylase regulator activity	SIRT6	IDA		Human	PMID:23892288
Molecular Function	GO:0035033	histone deacetylase regulator activity	SIRT6	IDA		Human	PMID:27043296
Molecular Function	GO:0035033	histone deacetylase regulator activity	SIRT6	IDA		Human	PMID:31995034
Molecular Function	GO:0035033	histone deacetylase regulator activity	SIRT6	IDA		Human	PMID:32538779
Molecular Function	GO:0035033	histone deacetylase regulator activity	SIRT6	IDA		Human	PMID:33067423
Molecular Function	GO:0106222	lncRNA binding	SIRT6	IDA		Human	PMID:27912097
Molecular Function	GO:0140677	molecular function activator activity	SIRT6	IDA		Human	PMID:21680843
Molecular Function	GO:0140677	molecular function activator activity	SIRT6	IDA		Human	PMID:23552949
Molecular Function	GO:0140677	molecular function activator activity	SIRT6	IDA		Human	PMID:27568560
Molecular Function	GO:0140677	molecular function activator activity	SIRT6	IDA		Human	PMID:30374165
Molecular Function	GO:0140677	molecular function activator activity	SIRT6	IDA		Human	PMID:31995034
Molecular Function	GO:0140677	molecular function activator activity	SIRT6	IDA		Human	PMID:32538779
Molecular Function	GO:0140677	molecular function activator activity	Sirt6	IDA		Mouse	PMID:31399344
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	SIRT6	IDA		Human	PMID:21680843
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	SIRT6	IDA		Human	PMID:22753495
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	SIRT6	IDA		Human	PMID:27322069
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	SIRT6	IDA		Human	PMID:27568560
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	Sirt6	IDA		Mouse	MGI:MGI:6455956\|PMID:31216030
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	Sirt6	IDA		Mouse	MGI:MGI:6214653\|PMID:25247314
Molecular Function	GO:0106274	NAD+-protein-arginine ADP-ribosyltransferase activity	Sirt6	IDA		Mouse	MGI:MGI:3584210\|PMID:15795229
Molecular Function	GO:0106274	NAD+-protein-arginine ADP-ribosyltransferase activity	Sirt6	IDA		Mouse	MGI:MGI:6694658\|PMID:32584788
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	SIRT6	IDA		Human	PMID:24043303
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	SIRT6	IDA		Human	PMID:27912097
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	SIRT6	IDA		Human	PMID:27043296
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	Sirt6	IDA		Mouse	MGI:MGI:7258357\|PMID:31002797
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	SIRT6	IDA		Human	PMID:23911928
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	SIRT6	IDA		Human	PMID:26456828
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	SIRT6	IDA		Human	PMID:26898756
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	SIRT6	IDA		Human	PMID:27912097
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	SIRT6	IDA		Human	PMID:30374165
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	Sirt6	IDA		Mouse	MGI:MGI:7258357\|PMID:31002797
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	Sirt6	IDA		Mouse	MGI:MGI:4867348\|PMID:21098266
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	Sirt6	IDA		Mouse	MGI:MGI:6103696\|PMID:28355567
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	Sirt6	IDA		Mouse	MGI:MGI:6757299\|PMID:25915124
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	Sirt6	IDA		Mouse	PMID:31399344
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	SIRT6	IDA		Human	PMID:18337721
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	SIRT6	IDA		Human	PMID:23892288
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	SIRT6	IDA		Human	PMID:26456828
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	SIRT6	IMP		Human	PMID:29555651
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	SIRT6	IDA		Human	PMID:30374165
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	SIRT6	IDA		Human	PMID:33067423
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	Sirt6	IMP		Mouse	MGI:MGI:6103696\|PMID:28355567
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	Sirt6	IMP		Mouse	MGI:MGI:6357632\|PMID:31399344
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	Sirt6	IMP		Mouse	MGI:MGI:4867348\|PMID:21098266
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	Sirt6	IMP		Mouse	MGI:MGI:6757299\|PMID:25915124
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	Sirt6	IDA		Mouse	MGI:MGI:7258357\|PMID:31002797
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	Sirt6	IMP		Mouse	MGI:MGI:4881401\|PMID:20141841
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	Sirt6	IMP		Mouse	MGI:MGI:6284084\|PMID:29555651
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	Sirt6	IDA		Mouse	PMID:31399344
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT6	IDA		Human	PMID:19109893
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT6	IDA		Human	PMID:23142079
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT6	IDA		Human	PMID:24052263
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT6	IDA		Human	PMID:25009184
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT6	IDA		Human	PMID:26787900
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT6	IDA		Human	PMID:27322069
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT6	IDA		Human	PMID:29474172
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt6	IDA		Mouse	MGI:MGI:6443593\|PMID:30782483
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt6	IDA		Mouse	MGI:MGI:6357356\|PMID:31442424
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt6	IDA		Mouse	MGI:MGI:6429981\|PMID:31851938
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt6	IDA		Mouse	MGI:MGI:6101624\|PMID:27457971
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity	SIRT6	IDA		Human	PMID:23552949
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity	SIRT6	IDA		Human	PMID:24052263
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity	SIRT6	IDA		Human	PMID:26456828
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity	SIRT6	IDA		Human	PMID:27322069
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity	SIRT6	IDA		Human	PMID:30374165
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity	SIRT6	IDA		Human	PMID:31995034
Molecular Function	GO:0140774	NAD-dependent protein depalmitoylase activity	SIRT6	IDA		Human	PMID:23552949
Molecular Function	GO:0140774	NAD-dependent protein depalmitoylase activity	SIRT6	IDA		Human	PMID:24052263
Molecular Function	GO:0140774	NAD-dependent protein depalmitoylase activity	SIRT6	IDA		Human	PMID:27322069
Molecular Function	GO:0140774	NAD-dependent protein depalmitoylase activity	SIRT6	IDA		Human	PMID:28406396
Molecular Function	GO:0140774	NAD-dependent protein depalmitoylase activity	SIRT6	IMP		Human	PMID:29555651
Molecular Function	GO:0031491	nucleosome binding	SIRT6	IDA		Human	PMID:23892288
Molecular Function	GO:0031491	nucleosome binding	SIRT6	IDA		Human	PMID:33067423
Molecular Function	GO:0005515	protein binding	SIRT6	IPI	UniProtKB:Q04206	Human	PMID:19135889
Molecular Function	GO:0005515	protein binding	SIRT6	IPI	UniProtKB:P01106	Human	PMID:23217706
Molecular Function	GO:0005515	protein binding	SIRT6	IPI	UniProtKB:O60264	Human	PMID:23911928
Molecular Function	GO:0005515	protein binding	Sirt6	IPI	RGD:727889	Rat	PMID:22335191\|RGD:9586060
Molecular Function	GO:0042803	protein homodimerization activity	SIRT6	IDA		Human	PMID:31995034
Molecular Function	GO:0042803	protein homodimerization activity	SIRT6	IDA		Human	PMID:32538779
Molecular Function	GO:0033558	protein lysine deacetylase activity	Sirt6	IDA		Rat	PMID:22335191\|RGD:9586060
Molecular Function	GO:1904841	TORC2 complex binding	Sirt6	IDA		Mouse	MGI:MGI:6357356\|PMID:31442424
Molecular Function	GO:0003714	transcription corepressor activity	Sirt6	IGI	UniProtKB:P01108	Mouse	MGI:MGI:5619441\|PMID:23217706
Molecular Function	GO:0140416	transcription regulator inhibitor activity	SIRT6	IDA		Human	PMID:29474172
Cellular Component	GO:0000785	chromatin	SIRT6	IDA		Human	PMID:23892288
Cellular Component	GO:0000785	chromatin	SIRT6	IDA		Human	PMID:27043296
Cellular Component	GO:0000785	chromatin	SIRT6	IDA		Human	PMID:27912097
Cellular Component	GO:0000785	chromatin	SIRT6	IDA		Human	PMID:30374165
Cellular Component	GO:0000785	chromatin	SIRT6	IDA		Human	PMID:33067423
Cellular Component	GO:0000785	chromatin	SIRT6	IDA		Human	PMID:26456828
Cellular Component	GO:0000785	chromatin	Sirt6	IDA		Mouse	PMID:31399344
Cellular Component	GO:0099115	chromosome, subtelomeric region	SIRT6	IDA		Human	PMID:18337721
Cellular Component	GO:0005737	cytoplasm	Sirt6	IDA		Rat	PMID:21502801\|RGD:9586061
Cellular Component	GO:0005783	endoplasmic reticulum	SIRT6	IDA		Human	PMID:23552949
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SIRT6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SIRT6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SIRT6	IDA		Human	PMID:16079181
Cellular Component	GO:0005634	nucleus	SIRT6	IDA		Human	PMID:26898756
Cellular Component	GO:0005634	nucleus	SIRT6	IDA		Human	PMID:29555651
Cellular Component	GO:0005634	nucleus	SIRT6	IDA		Human	PMID:25819580
Cellular Component	GO:0005634	nucleus	SIRT6	IDA		Human	PMID:26456828
Cellular Component	GO:0005634	nucleus	Sirt6	IDA		Mouse	MGI:MGI:5619429\|PMID:24063863
Cellular Component	GO:0005634	nucleus	Sirt6	IDA		Mouse	MGI:MGI:3584210\|PMID:15795229
Cellular Component	GO:0005634	nucleus	Sirt6	IDA		Rat	PMID:21502801\|RGD:9586061
Cellular Component	GO:0005721	pericentric heterochromatin	SIRT6	IDA		Human	PMID:27043296
Cellular Component	GO:0090734	site of DNA damage	SIRT6	IDA		Human	PMID:19109893
Cellular Component	GO:0035861	site of double-strand break	SIRT6	IDA		Human	PMID:21680843
Cellular Component	GO:0035861	site of double-strand break	SIRT6	IDA		Human	PMID:23911928
Cellular Component	GO:0035861	site of double-strand break	SIRT6	IDA		Human	PMID:27568560
Cellular Component	GO:0035861	site of double-strand break	SIRT6	IDA		Human	PMID:31995034
Cellular Component	GO:0035861	site of double-strand break	SIRT6	IDA		Human	PMID:32538779
Biological Process	GO:0006284	base-excision repair	Sirt6	IMP		Mouse	MGI:MGI:3663736\|PMID:16439206
Biological Process	GO:0055007	cardiac muscle cell differentiation	Sirt6	IMP		Mouse	MGI:MGI:6284084\|PMID:29555651
Biological Process	GO:1904385	cellular response to angiotensin	Sirt6	IEP		Rat	PMID:30894089\|RGD:155260334
Biological Process	GO:1990859	cellular response to endothelin	Sirt6	IEP		Rat	PMID:30894089\|RGD:155260334
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Sirt6	IEP		Rat	PMID:30894089\|RGD:155260334
Biological Process	GO:0032922	circadian regulation of gene expression	Sirt6	IMP		Mouse	MGI:MGI:5603468\|PMID:25083875
Biological Process	GO:0008340	determination of adult lifespan	SIRT6	IMP		Human	PMID:25541994
Biological Process	GO:0008340	determination of adult lifespan	Sirt6	IMP		Mouse	MGI:MGI:7258357\|PMID:31002797
Biological Process	GO:0006281	DNA repair	Sirt6	IDA		Mouse	MGI:MGI:6694658\|PMID:32584788
Biological Process	GO:0006302	double-strand break repair	SIRT6	IDA		Human	PMID:21680843
Biological Process	GO:0006302	double-strand break repair	SIRT6	IDA		Human	PMID:27568560
Biological Process	GO:0042593	glucose homeostasis	Sirt6	IMP		Mouse	MGI:MGI:3663736\|PMID:16439206
Biological Process	GO:0016575	histone deacetylation	SIRT6	IDA		Human	PMID:23892288
Biological Process	GO:0042181	ketone biosynthetic process	Sirt6	IMP		Mouse	MGI:MGI:6294537\|PMID:30530497
Biological Process	GO:0008285	negative regulation of cell population proliferation	Sirt6	IMP		Mouse	MGI:MGI:5619441\|PMID:23217706
Biological Process	GO:2000773	negative regulation of cellular senescence	SIRT6	IDA		Human	PMID:22753495
Biological Process	GO:2000773	negative regulation of cellular senescence	SIRT6	IDA		Human	PMID:27043296
Biological Process	GO:2000773	negative regulation of cellular senescence	SIRT6	IMP		Human	PMID:29474172
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Sirt6	IMP		Mouse	MGI:MGI:4881401\|PMID:20141841
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	SIRT6	IMP		Human	PMID:21847107
Biological Process	GO:0045721	negative regulation of gluconeogenesis	SIRT6	IDA		Human	PMID:23142079
Biological Process	GO:0045721	negative regulation of gluconeogenesis	SIRT6	IDA		Human	PMID:25009184
Biological Process	GO:0046325	negative regulation of glucose import	Sirt6	IMP		Mouse	MGI:MGI:4881401\|PMID:20141841
Biological Process	GO:0045820	negative regulation of glycolytic process	SIRT6	IDA		Human	PMID:26456828
Biological Process	GO:0045820	negative regulation of glycolytic process	Sirt6	IMP		Mouse	MGI:MGI:5619441\|PMID:23217706
Biological Process	GO:0045820	negative regulation of glycolytic process	Sirt6	IMP		Mouse	MGI:MGI:4881401\|PMID:20141841
Biological Process	GO:0042308	negative regulation of protein import into nucleus	Sirt6	IMP		Mouse	MGI:MGI:6103696\|PMID:28355567
Biological Process	GO:0120186	negative regulation of protein localization to chromatin	SIRT6	IDA		Human	PMID:27912097
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SIRT6	IDA		Human	PMID:24043303
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sirt6	IMP		Mouse	MGI:MGI:6357632\|PMID:31399344
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Sirt6	IMP		Mouse	MGI:MGI:6103696\|PMID:28355567
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	Sirt6	IDA		Mouse	MGI:MGI:6214653\|PMID:25247314
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	Sirt6	IDA		Mouse	PMID:31399344
Biological Process	GO:0010529	negative regulation of transposition	Sirt6	IMP		Mouse	MGI:MGI:6303534\|PMID:30853213
Biological Process	GO:0010529	negative regulation of transposition	Sirt6	IDA		Mouse	MGI:MGI:6214653\|PMID:25247314
Biological Process	GO:0031508	pericentric heterochromatin formation	SIRT6	IDA		Human	PMID:27043296
Biological Process	GO:1905555	positive regulation of blood vessel branching	SIRT6	IMP		Human	PMID:23201774
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	SIRT6	IMP		Human	PMID:25819580
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Sirt6	IMP		Mouse	MGI:MGI:6101021\|PMID:28723567
Biological Process	GO:2000781	positive regulation of double-strand break repair	SIRT6	IDA		Human	PMID:23911928
Biological Process	GO:2000781	positive regulation of double-strand break repair	SIRT6	IDA		Human	PMID:31995034
Biological Process	GO:2000781	positive regulation of double-strand break repair	SIRT6	IDA		Human	PMID:32538779
Biological Process	GO:2000781	positive regulation of double-strand break repair	Sirt6	IDA		Mouse	MGI:MGI:7258357\|PMID:31002797
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Sirt6	IMP		Mouse	MGI:MGI:6103696\|PMID:28355567
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Sirt6	IMP		Mouse	MGI:MGI:3663736\|PMID:16439206
Biological Process	GO:1901727	positive regulation of histone deacetylase activity	SIRT6	IDA		Human	PMID:23892288
Biological Process	GO:1901727	positive regulation of histone deacetylase activity	SIRT6	IDA		Human	PMID:33067423
Biological Process	GO:0032024	positive regulation of insulin secretion	Sirt6	IDA		Mouse	MGI:MGI:6101624\|PMID:27457971
Biological Process	GO:0046827	positive regulation of protein export from nucleus	SIRT6	IDA		Human	PMID:25009184
Biological Process	GO:0046827	positive regulation of protein export from nucleus	SIRT6	IDA		Human	PMID:26787900
Biological Process	GO:0046827	positive regulation of protein export from nucleus	Sirt6	IDA		Mouse	MGI:MGI:6101624\|PMID:27457971
Biological Process	GO:0120187	positive regulation of protein localization to chromatin	Sirt6	IMP		Mouse	MGI:MGI:6357632\|PMID:31399344
Biological Process	GO:0120187	positive regulation of protein localization to chromatin	Sirt6	IDA		Mouse	PMID:31399344
Biological Process	GO:2000738	positive regulation of stem cell differentiation	SIRT6	IDA		Human	PMID:27912097
Biological Process	GO:2000738	positive regulation of stem cell differentiation	Sirt6	IMP		Mouse	MGI:MGI:6757299\|PMID:25915124
Biological Process	GO:2000738	positive regulation of stem cell differentiation	Sirt6	IMP		Mouse	MGI:MGI:6284084\|PMID:29555651
Biological Process	GO:1902459	positive regulation of stem cell population maintenance	SIRT6	IDA		Human	PMID:27912097
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Sirt6	IMP		Mouse	MGI:MGI:3663736\|PMID:16439206
Biological Process	GO:0032206	positive regulation of telomere maintenance	SIRT6	IMP		Human	PMID:23201774
Biological Process	GO:0032206	positive regulation of telomere maintenance	SIRT6	IMP		Human	PMID:25819580
Biological Process	GO:1901485	positive regulation of transcription factor catabolic process	SIRT6	IMP		Human	PMID:27457971
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	SIRT6	IMP		Human	PMID:23201774
Biological Process	GO:0003247	post-embryonic cardiac muscle cell growth involved in heart morphogenesis	Sirt6	IMP		Rat	PMID:22335191\|RGD:9586060
Biological Process	GO:0006476	protein deacetylation	SIRT6	IMP		Human	PMID:27457971
Biological Process	GO:0006476	protein deacetylation	Sirt6	IMP		Mouse	MGI:MGI:6101624\|PMID:27457971
Biological Process	GO:0051697	protein delipidation	SIRT6	IDA		Human	PMID:23552949
Biological Process	GO:0031648	protein destabilization	SIRT6	IDA		Human	PMID:29474172
Biological Process	GO:0031648	protein destabilization	SIRT6	IMP		Human	PMID:29474172
Biological Process	GO:0031648	protein destabilization	Sirt6	IMP		Mouse	MGI:MGI:4881401\|PMID:20141841
Biological Process	GO:1990166	protein localization to site of double-strand break	SIRT6	IDA		Human	PMID:27568560
Biological Process	GO:0042752	regulation of circadian rhythm	Sirt6	IMP		Mouse	MGI:MGI:6443593\|PMID:30782483
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	SIRT6	IDA		Human	PMID:19135889
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	SIRT6	IDA		Human	PMID:22753495
Biological Process	GO:0050994	regulation of lipid catabolic process	Sirt6	IMP		Mouse	MGI:MGI:6357356\|PMID:31442424
Biological Process	GO:0019216	regulation of lipid metabolic process	Sirt6	IDA		Mouse	MGI:MGI:6429981\|PMID:31851938
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	SIRT6	IDA		Human	PMID:28406396
Biological Process	GO:0050708	regulation of protein secretion	SIRT6	IDA		Human	PMID:23552949
Biological Process	GO:0031667	response to nutrient levels	Sirt6	IEP		Rat	PMID:22321393\|RGD:9586063
Biological Process	GO:0009411	response to UV	SIRT6	IDA		Human	PMID:19109893
Biological Process	GO:0031509	subtelomeric heterochromatin formation	SIRT6	IMP		Human	PMID:21847107

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.