Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIRT7
  • Mouse genes Sirt7
  • Rat genes Sirt7
  • Zfish genes sirt7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sirt7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	SIRT7	IDA		Human	PMID:22722849
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	SIRT7	IDA		Human	PMID:22722849
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	SIRT7	IDA		Human	PMID:26907567
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	SIRT7	IMP		Human	PMID:28655758
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	SIRT7	IDA		Human	PMID:30420520
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	SIRT7	IDA		Human	PMID:30653310
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	SIRT7	IDA		Human	PMID:35939806
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	Sirt7	IMP		Mouse	MGI:MGI:6378020|PMID:31256246
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	Sirt7	IMP		Mouse	MGI:MGI:5789069|PMID:27225932
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT7	IDA		Human	PMID:24207024
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT7	IDA		Human	PMID:26867678
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT7	IDA		Human	PMID:28426094
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT7	IDA		Human	PMID:28790157
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT7	IDA		Human	PMID:28886238
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT7	IDA		Human	PMID:30540930
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT7	IDA		Human	PMID:30944854
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	SIRT7	IDA		Human	PMID:31075303
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt7	IDA		Mouse	MGI:MGI:6323967|PMID:31075303
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	Sirt7	IDA		Mouse	MGI:MGI:6287163|PMID:25200183
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:P17480	Human	PMID:19174463
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:P28324	Human	PMID:22722849
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:Q9GZS1	Human	PMID:24207024
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:Q16656	Human	PMID:25792330
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:O43818	Human	PMID:26867678
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:P50750	Human	PMID:28426094
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:Q93009	Human	PMID:28655758
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:Q9NR30	Human	PMID:28790157
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:Q96LA8	Human	PMID:30420520
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:P22087	Human	PMID:30540930
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:Q13315	Human	PMID:30944854
Molecular Function	GO:0005515	protein binding	SIRT7	IPI	UniProtKB:P62826	Human	PMID:31075303
Molecular Function	GO:0005515	protein binding	Sirt7	IPI	UniProtKB:Q00420	Mouse	MGI:MGI:6287163|PMID:25200183
Molecular Function	GO:0008276	protein methyltransferase activity	SIRT7	IDA		Human	PMID:24207024
Molecular Function	GO:0061697	protein-glutaryllysine deglutarylase activity	SIRT7	IDA		Human	PMID:31542297
Molecular Function	GO:0106231	protein-propionyllysine depropionylase activity	Sirt7	IDA		Mouse	MGI:MGI:6209006|PMID:30026585
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	SIRT7	IDA		Human	PMID:27436229
Cellular Component	GO:0000785	chromatin	SIRT7	IDA		Human	PMID:30944854
Cellular Component	GO:0000785	chromatin	Sirt7	IDA		Mouse	MGI:MGI:6377981|PMID:31226208
Cellular Component	GO:0016607	nuclear speck	SIRT7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	SIRT7	IDA		Human	PMID:16079181
Cellular Component	GO:0005730	nucleolus	SIRT7	IDA		Human	PMID:24207024
Cellular Component	GO:0005730	nucleolus	SIRT7	IDA		Human	PMID:28426094
Cellular Component	GO:0005730	nucleolus	SIRT7	IDA		Human	PMID:28886238
Cellular Component	GO:0005731	nucleolus organizer region	SIRT7	IDA		Human	PMID:19174463
Cellular Component	GO:0005654	nucleoplasm	SIRT7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SIRT7	IDA		Human	PMID:24207024
Cellular Component	GO:0005654	nucleoplasm	SIRT7	IDA		Human	PMID:28886238
Cellular Component	GO:0005634	nucleus	SIRT7	IDA		Human	PMID:36646384
Cellular Component	GO:0005634	nucleus	SIRT7	IDA		Human	PMID:31075303
Cellular Component	GO:0035861	site of double-strand break	SIRT7	IDA		Human	PMID:27436229
Cellular Component	GO:0035861	site of double-strand break	Sirt7	IMP		Mouse	MGI:MGI:5789069|PMID:27225932
Biological Process	GO:0006974	DNA damage response	SIRT7	IDA		Human	PMID:30944854
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	SIRT7	IDA		Human	PMID:27436229
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	Sirt7	IMP		Mouse	MGI:MGI:5789069|PMID:27225932
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	sirt7	IMP	ZFIN:ZDB-MRPHLNO-141230-10	Zfish	PMID:24240475
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	Sirt7	IMP		Mouse	MGI:MGI:6378020|PMID:31256246
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	Sirt7	IMP		Mouse	MGI:MGI:6377981|PMID:31226208
Biological Process	GO:0031397	negative regulation of protein ubiquitination	SIRT7	IDA		Human	PMID:28886238
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SIRT7	IDA		Human	PMID:22722849
Biological Process	GO:0010529	negative regulation of transposition	Sirt7	IMP		Mouse	MGI:MGI:6377981|PMID:31226208
Biological Process	GO:0001649	osteoblast differentiation	Sirt7	IMP		Mouse	MGI:MGI:6209006|PMID:30026585
Biological Process	GO:0045722	positive regulation of gluconeogenesis	SIRT7	IMP		Human	PMID:28655758
Biological Process	GO:2000234	positive regulation of rRNA processing	SIRT7	IDA		Human	PMID:26867678
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	SIRT7	IDA		Human	PMID:30540930
Biological Process	GO:0007072	positive regulation of transcription involved in exit from mitosis	SIRT7	IMP		Human	PMID:19174463
Biological Process	GO:0006476	protein deacetylation	SIRT7	IDA		Human	PMID:24207024
Biological Process	GO:0006476	protein deacetylation	SIRT7	IDA		Human	PMID:26867678
Biological Process	GO:0006476	protein deacetylation	SIRT7	IDA		Human	PMID:28790157
Biological Process	GO:0006476	protein deacetylation	SIRT7	IDA		Human	PMID:28886238
Biological Process	GO:0006476	protein deacetylation	SIRT7	IDA		Human	PMID:30944854
Biological Process	GO:0006476	protein deacetylation	SIRT7	IDA		Human	PMID:31075303
Biological Process	GO:0006476	protein deacetylation	Sirt7	IDA		Mouse	MGI:MGI:6323967|PMID:31075303
Biological Process	GO:0006476	protein deacetylation	Sirt7	IDA		Mouse	MGI:MGI:6287163|PMID:25200183
Biological Process	GO:0061698	protein deglutarylation	SIRT7	IDA		Human	PMID:31542297
Biological Process	GO:0106230	protein depropionylation	Sirt7	IDA		Mouse	MGI:MGI:6209006|PMID:30026585
Biological Process	GO:0062176	R-loop processing	SIRT7	IDA		Human	PMID:28790157
Biological Process	GO:0006282	regulation of DNA repair	SIRT7	IDA		Human	PMID:30944854
Biological Process	GO:0010821	regulation of mitochondrion organization	SIRT7	IMP		Human	PMID:30420520
Biological Process	GO:0010821	regulation of mitochondrion organization	Sirt7	IMP		Mouse	MGI:MGI:6287163|PMID:25200183
Biological Process	GO:0046825	regulation of protein export from nucleus	Sirt7	IMP		Mouse	MGI:MGI:6323967|PMID:31075303
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	SIRT7	IDA		Human	PMID:28426094
Biological Process	GO:1901836	regulation of transcription of nucleolar large rRNA by RNA polymerase I	SIRT7	IDA		Human	PMID:24207024
Biological Process	GO:0009303	rRNA transcription	SIRT7	IMP		Human	PMID:19174463
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	SIRT7	IDA		Human	PMID:28655758

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern