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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Six1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Six1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003682chromatin bindingSix1IGIMGI:MGI:109339MousePMID:19008232
Molecular FunctionGO:0003682chromatin bindingSix1IGIMGI:MGI:98310MousePMID:19008232
Molecular FunctionGO:0003677DNA bindingSIX1IDAHumanPMID:19497856
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSIX1IDAHumanPMID:15141091
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificSIX1IMPHumanPMID:15141091
Molecular FunctionGO:0003700DNA-binding transcription factor activitySIX1IDAHumanPMID:19497856
Molecular FunctionGO:0003700DNA-binding transcription factor activitySix1IDAMousePMID:15955062
Molecular FunctionGO:0000981DNA-binding transcription factor activity, RNA polymerase II-specificsix1aIMPZfishPMID:21745464
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:O35984HumanPMID:15141091
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:Q99502HumanPMID:15141091
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:Q99750HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:O00167HumanPMID:19497856
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:O00167HumanPMID:20211142
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:O00167HumanPMID:21516116
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:O00167-1HumanPMID:23435380
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:Q08117HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:Q08117-2HumanPMID:25910212
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:O95935HumanPMID:26235987
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:O08792HumanPMID:27923061
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:P28033HumanPMID:27923061
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:P53566HumanPMID:27923061
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:Q99502HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:O00167-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:O75409HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:P78424HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:Q04726-4HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:Q04864-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:Q08117-2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:Q58EX7HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSIX1IPIUniProtKB:Q99502HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingSix1IPIUniProtKB:P97767MouseMGI:MGI:3722498|PMID:11734542
Molecular FunctionGO:0005515protein bindingSix1IPIUniProtKB:P12755MouseMGI:MGI:3839724|PMID:19008232
Molecular FunctionGO:0005515protein bindingSix1IPIUniProtKB:P97767MouseMGI:MGI:3044439|PMID:15141091
Molecular FunctionGO:0005515protein bindingSix1IPIUniProtKB:P97480MouseMGI:MGI:5582180|PMID:12215533
Molecular FunctionGO:0005515protein bindingSix1IPIPR:P70660MousePMID:22513373
Molecular FunctionGO:0005515protein bindingSix1IPIPR:Q9EPZ6MousePMID:20110314
Molecular FunctionGO:0005515protein bindingSix1IPIPR:Q60867MousePMID:22513373
Molecular FunctionGO:0005515protein bindingSix1IPIPR:Q6PDG5MousePMID:22513373
Molecular FunctionGO:0005515protein bindingSix1IPIPR:Q3TKT4MousePMID:22513373
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSIX1IDAHumanPMID:15141091
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingSIX1IMPHumanPMID:15141091
Molecular FunctionGO:0043565sequence-specific DNA bindingSIX1IDAHumanPMID:15141091
Molecular FunctionGO:0043565sequence-specific DNA bindingSix1IDAMousePMID:9826681
Molecular FunctionGO:0043565sequence-specific DNA bindingSix1IDAMousePMID:17098221
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingSIX1IDAHumanPMID:28473536
Molecular FunctionGO:0000976transcription cis-regulatory region bindingSIX1IDAHumanPMID:16670092
Molecular FunctionGO:0001223transcription coactivator bindingSix1IPIRGD:620096RatPMID:22197309|RGD:11561984
Molecular FunctionGO:0001223transcription coactivator bindingSix1IPIRGD:1307099RatPMID:26499333|RGD:11536910
Cellular ComponentGO:0005730nucleolusSIX1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005654nucleoplasmSIX1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusSIX1IDAHumanPMID:16670092
Cellular ComponentGO:0005634nucleusSIX1IDAHumanPMID:19497856
Cellular ComponentGO:0005634nucleusSix1IDAMousePMID:14628042
Cellular ComponentGO:0005634nucleusSix1IDAMousePMID:9826681
Cellular ComponentGO:0005634nucleusSix1IDARatPMID:26499333|RGD:11536910
Cellular ComponentGO:0005667transcription regulator complexSix1IDAMousePMID:14628042
Cellular ComponentGO:0005667transcription regulator complexSix1IPIUniProtKB:97480MousePMID:19008232
Cellular ComponentGO:0005667transcription regulator complexSix1IPIPR:Q60698MousePMID:19008232
Biological ProcessGO:0021984adenohypophysis developmentsix1bIGIZFIN:ZDB-GENO-980202-1557,ZFIN:ZDB-MRPHLNO-060606-5,ZFIN:ZDB-MRPHLNO-060606-6ZfishPMID:16458879
Biological ProcessGO:0048856anatomical structure developmentSix1IGIMGI:MGI:109344MousePMID:16530750
Biological ProcessGO:0048856anatomical structure developmentSix1IGIMGI:MGI:106034MousePMID:16530750
Biological ProcessGO:0035909aorta morphogenesisSix1IGIMGI:MGI:109344MousePMID:21364285
Biological ProcessGO:0035909aorta morphogenesisSix1IGIMGI:MGI:99604MousePMID:21364285
Biological ProcessGO:0035909aorta morphogenesisSix1IGIMGI:MGI:98493MousePMID:21364285
Biological ProcessGO:0001658branching involved in ureteric bud morphogenesisSix1IGIMGI:MGI:109344MousePMID:12783782
Biological ProcessGO:1905243cellular response to 3,3',5-triiodo-L-thyronineSix1IDARatPMID:22197309|RGD:11561984
Biological ProcessGO:0090103cochlea morphogenesisSix1IMPMGI:MGI:2655195MousePMID:12874121
Biological ProcessGO:0048701embryonic cranial skeleton morphogenesisSix1IGIMGI:MGI:106034MousePMID:20515681
Biological ProcessGO:0048704embryonic skeletal system morphogenesisSix1IGIMGI:MGI:106034MousePMID:15788460
Biological ProcessGO:0086100endothelin receptor signaling pathwaySix1IMPMGI:MGI:3612276MousePMID:28455376
Biological ProcessGO:0030855epithelial cell differentiationSix1IMPMGI:MGI:2655195MousePMID:16530750
Biological ProcessGO:0002074extraocular skeletal muscle developmentsix1bIMPZFIN:ZDB-MRPHLNO-060606-5ZfishPMID:19409884
Biological ProcessGO:0021610facial nerve morphogenesisSix1IMPMGI:MGI:2655195MousePMID:12874121
Biological ProcessGO:0061197fungiform papilla morphogenesisSix1IMPMouseMGI:MGI:5448822|PMID:21978088
Biological ProcessGO:0010467gene expressionSix1IMPMGI:MGI:3612276MousePMID:28455376
Biological ProcessGO:0048699generation of neuronsSix1IMPMouseMGI:MGI:3689152|PMID:16938278
Biological ProcessGO:0048839inner ear developmentSix1IMPMouseMGI:MGI:3848573|PMID:19389353
Biological ProcessGO:0048839inner ear developmentsix1bIMPZFIN:ZDB-MRPHLNO-061106-1ZfishPMID:17035528
Biological ProcessGO:0042472inner ear morphogenesisSix1IGIMGI:MGI:106034MousePMID:15788460
Biological ProcessGO:0001822kidney developmentSix1IMPMouseMGI:MGI:3702799|PMID:16934795
Biological ProcessGO:0072198mesenchymal cell proliferation involved in ureter developmentSix1IGIMGI:MGI:1923615MousePMID:20110314
Biological ProcessGO:0072172mesonephric tubule formationSix1IMPMouseMGI:MGI:5009396|PMID:17300925
Biological ProcessGO:0072075metanephric mesenchyme developmentSix1IMPMouseMGI:MGI:5009396|PMID:17300925
Biological ProcessGO:0042474middle ear morphogenesisSix1IMPMGI:MGI:2655195MousePMID:12874121
Biological ProcessGO:0051451myoblast migrationSix1IGIMGI:MGI:106034MousePMID:15788460
Biological ProcessGO:0051450myoblast proliferationSix1IGIMGI:MGI:1923615MousePMID:20110314
Biological ProcessGO:0061055myotome developmentSix1IMPMouseMGI:MGI:3578604|PMID:15788460
Biological ProcessGO:0061055myotome developmentSix1IMPMouseMGI:MGI:4421263|PMID:19962975
Biological ProcessGO:0043066negative regulation of apoptotic processSix1IMPMouseMGI:MGI:3578604|PMID:15788460
Biological ProcessGO:0043066negative regulation of apoptotic processSix1IMPMouseMGI:MGI:3833798|PMID:19027001
Biological ProcessGO:0043524negative regulation of neuron apoptotic processSix1IMPMouseMGI:MGI:3689152|PMID:16938278
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IISix1IDAMousePMID:21281623
Biological ProcessGO:0014033neural crest cell differentiationSix1IGIMGI:MGI:105923MousePMID:28455376
Biological ProcessGO:0022008neurogenesisSix1IMPMouseMGI:MGI:3833798|PMID:19027001
Biological ProcessGO:0048665neuron fate specificationSix1IGIMGI:MGI:109344MousePMID:22513373
Biological ProcessGO:0007219Notch signaling pathwaySix1IMPMGI:MGI:3612276MousePMID:28455376
Biological ProcessGO:0030910olfactory placode formationSix1IMPMouseMGI:MGI:3833798|PMID:19027001
Biological ProcessGO:0001759organ inductionSix1IMPMGI:MGI:2655195MousePMID:12783782
Biological ProcessGO:0071599otic vesicle developmentSix1IMPMGI:MGI:2655195MousePMID:16916509
Biological ProcessGO:0071599otic vesicle developmentSix1IGIMGI:MGI:109344MousePMID:22513373
Biological ProcessGO:0003151outflow tract morphogenesisSix1IGIMGI:MGI:98493MousePMID:21364285
Biological ProcessGO:0003151outflow tract morphogenesisSix1IGIMGI:MGI:109344MousePMID:21364285
Biological ProcessGO:0003151outflow tract morphogenesisSix1IGIMGI:MGI:99604MousePMID:21364285
Biological ProcessGO:0007389pattern specification processSix1IMPMGI:MGI:2655195MousePMID:16916509
Biological ProcessGO:0007389pattern specification processSix1IGIMGI:MGI:109344MousePMID:16530750
Biological ProcessGO:0048935peripheral nervous system neuron developmentsix1bIMPZFIN:ZDB-MRPHLNO-061106-1ZfishPMID:17035528
Biological ProcessGO:0043282pharyngeal muscle developmentsix1bIMPZFIN:ZDB-MRPHLNO-060606-5ZfishPMID:19409884
Biological ProcessGO:0060037pharyngeal system developmentSix1IMPMouseMGI:MGI:3624596|PMID:16530750
Biological ProcessGO:0060037pharyngeal system developmentSix1IGIMGI:MGI:99604MousePMID:21364285
Biological ProcessGO:0060037pharyngeal system developmentSix1IGIMGI:MGI:109344MousePMID:21364285
Biological ProcessGO:0060037pharyngeal system developmentSix1IGIMGI:MGI:98493MousePMID:21364285
Biological ProcessGO:0090190positive regulation of branching involved in ureteric bud morphogenesisSix1IMPMouseMGI:MGI:5009396|PMID:17300925
Biological ProcessGO:0090190positive regulation of branching involved in ureteric bud morphogenesisSix1IGIMGI:MGI:88180MousePMID:21281623
Biological ProcessGO:0090336positive regulation of brown fat cell differentiationSix1IMPMouseMGI:MGI:5812817|PMID:27923061
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSIX1IMPHumanPMID:27923061
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSix1IMPMouseMGI:MGI:3715562|PMID:17592144
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSix1IMPMouseMGI:MGI:5009396|PMID:17300925
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSix1IDAMouseMGI:MGI:4836102|PMID:20696153
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionSix1IDAMouseMGI:MGI:4421263|PMID:19962975
Biological ProcessGO:2000729positive regulation of mesenchymal cell proliferation involved in ureter developmentSix1IGIMGI:MGI:1923615MousePMID:20110314
Biological ProcessGO:2000288positive regulation of myoblast proliferationSix1IGIMGI:MGI:1923615MousePMID:20110314
Biological ProcessGO:0072513positive regulation of secondary heart field cardioblast proliferationSix1IGIMGI:MGI:109344MousePMID:21364285
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISIX1IDAHumanPMID:15141091
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISIX1IMPHumanPMID:15141091
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISix1IGIMGI:MGI:109344MousePMID:22513373
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISix1IGIMGI:MGI:109344MousePMID:21364285
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IISix1IDAMousePMID:15955062
Biological ProcessGO:0072107positive regulation of ureteric bud formationSix1IMPMouseMGI:MGI:5009396|PMID:17300925
Biological ProcessGO:0034504protein localization to nucleusSIX1IDAHumanPMID:19497856
Biological ProcessGO:0072095regulation of branch elongation involved in ureteric bud branchingSix1IMPMouseMGI:MGI:5009396|PMID:17300925
Biological ProcessGO:0006355regulation of DNA-templated transcriptionSix1IDAMousePMID:14628042
Biological ProcessGO:0050678regulation of epithelial cell proliferationSix1IMPMouseMGI:MGI:3833798|PMID:19027001
Biological ProcessGO:0010468regulation of gene expressionSix1IGIMGI:MGI:106034MousePMID:21884692
Biological ProcessGO:2000980regulation of inner ear receptor cell differentiationsix1aIMPZfishPMID:21745464
Biological ProcessGO:0045664regulation of neuron differentiationSix1IMPMGI:MGI:2655195MousePMID:15496442
Biological ProcessGO:0045664regulation of neuron differentiationSix1IGIMGI:MGI:107754MousePMID:22513373
Biological ProcessGO:0045664regulation of neuron differentiationSix1IGIMGI:MGI:1339708MousePMID:22513373
Biological ProcessGO:0045664regulation of neuron differentiationSix1IGIMGI:MGI:109344MousePMID:22513373
Biological ProcessGO:0045664regulation of neuron differentiationSix1IGIMGI:MGI:98364MousePMID:22513373
Biological ProcessGO:0032880regulation of protein localizationSix1IGIMGI:MGI:106034MousePMID:21884692
Biological ProcessGO:2001014regulation of skeletal muscle cell differentiationSix1IDAMouseMGI:MGI:4836102|PMID:20696153
Biological ProcessGO:0014857regulation of skeletal muscle cell proliferationsix1bIGIZFIN:ZDB-GENE-040718-155,ZFIN:ZDB-MRPHLNO-081211-1,ZFIN:ZDB-MRPHLNO-130710-1ZfishPMID:23444384
Biological ProcessGO:0014857regulation of skeletal muscle cell proliferationsix1bIMPZFIN:ZDB-MRPHLNO-081211-1ZfishPMID:23444384
Biological ProcessGO:0014857regulation of skeletal muscle cell proliferationsix1aIGIZFIN:ZDB-GENE-040426-2308,ZFIN:ZDB-MRPHLNO-081211-1,ZFIN:ZDB-MRPHLNO-130710-1ZfishPMID:23444384
Biological ProcessGO:0014857regulation of skeletal muscle cell proliferationsix1aIMPZFIN:ZDB-MRPHLNO-130710-1ZfishPMID:23444384
Biological ProcessGO:0014842regulation of skeletal muscle satellite cell proliferationSix1IDAMouseMGI:MGI:4836102|PMID:20696153
Biological ProcessGO:0008582regulation of synaptic assembly at neuromuscular junctionSix1IGIMGI:MGI:106034MousePMID:21884692
Biological ProcessGO:0007605sensory perception of soundSix1IMPMGI:MGI:2655195MousePMID:12874121
Biological ProcessGO:0048741skeletal muscle fiber developmentsix1bIGIZFIN:ZDB-MRPHLNO-081211-1,ZFIN:ZDB-MRPHLNO-140806-3ZfishPMID:24634509
Biological ProcessGO:0048741skeletal muscle fiber developmentsix1aIGIZFIN:ZDB-MRPHLNO-081211-1,ZFIN:ZDB-MRPHLNO-140806-3ZfishPMID:24634509
Biological ProcessGO:0048741skeletal muscle fiber developmentsix1aIMPZFIN:ZDB-MRPHLNO-140806-3ZfishPMID:24634509
Biological ProcessGO:0007519skeletal muscle tissue developmentSix1IMPMouseMGI:MGI:3715562|PMID:17592144
Biological ProcessGO:0007519skeletal muscle tissue developmentSix1IGIMGI:MGI:106034MousePMID:15788460
Biological ProcessGO:0048705skeletal system morphogenesisSix1IMPMGI:MGI:2655195MousePMID:12874121
Biological ProcessGO:0007382specification of segmental identity, maxillary segmentSix1IMPMGI:MGI:3612276MousePMID:28455376
Biological ProcessGO:0051146striated muscle cell differentiationsix1bIMPZFIN:ZDB-MRPHLNO-081211-1ZfishPMID:18789916
Biological ProcessGO:0051146striated muscle cell differentiationsix1bIMPZFIN:ZDB-MRPHLNO-081211-2ZfishPMID:18789916
Biological ProcessGO:0048538thymus developmentSix1IMPMGI:MGI:2655195MousePMID:16530750
Biological ProcessGO:0048538thymus developmentSix1IGIMGI:MGI:106034MousePMID:16530750
Biological ProcessGO:0030878thyroid gland developmentSix1IMPMGI:MGI:2655195MousePMID:16530750
Biological ProcessGO:0043586tongue developmentSix1IMPMouseMGI:MGI:5448822|PMID:21978088
Biological ProcessGO:0061551trigeminal ganglion developmentSix1IMPMouseMGI:MGI:3689152|PMID:16938278
Biological ProcessGO:0072193ureter smooth muscle cell differentiationSix1IMPMGI:MGI:2655195MousePMID:20110314
Biological ProcessGO:0001657ureteric bud developmentSix1IGIMGI:MGI:97486MousePMID:16018995
Biological ProcessGO:0001657ureteric bud developmentSix1IGIMGI:MGI:109344MousePMID:16018995
Biological ProcessGO:0001657ureteric bud developmentSix1IMPMGI:MGI:2655195MousePMID:12783782

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory