Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIX2
  • Mouse genes Six2
  • Rat genes Six2
  • Zfish genes six2a,six2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Six2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Six2	IDA		Mouse	MGI:MGI:3510065|PMID:15327782
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Six2	IDA		Mouse	PMID:15327782
Molecular Function	GO:0005515	protein binding	SIX2	IPI	UniProtKB:Q04206-1	Human	PMID:30894749
Molecular Function	GO:0005515	protein binding	SIX2	IPI	UniProtKB:Q04726-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIX2	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SIX2	IPI	UniProtKB:Q8N3C7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Six2	IPI	UniProtKB:P97767	Mouse	MGI:MGI:5437425|PMID:20956555
Molecular Function	GO:0005515	protein binding	Six2	IPI	UniProtKB:P97767	Mouse	MGI:MGI:3722498|PMID:11734542
Molecular Function	GO:0005515	protein binding	Six2	IPI	UniProtKB:P97480	Mouse	MGI:MGI:5582180|PMID:12215533
Molecular Function	GO:0044877	protein-containing complex binding	Six2	IDA		Mouse	MGI:MGI:3768605|PMID:17785448
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Six2	IDA		Mouse	MGI:MGI:3510065|PMID:15327782
Molecular Function	GO:0043565	sequence-specific DNA binding	Six2	IDA		Mouse	PMID:15327782
Molecular Function	GO:0043565	sequence-specific DNA binding	Six2	IDA		Mouse	PMID:8814301
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SIX2	IDA		Human	PMID:28473536
Molecular Function	GO:0008134	transcription factor binding	Six2	IPI	UniProtKB:P31311|UniProtKB:Q924A0	Mouse	MGI:MGI:5442222|PMID:22902740
Molecular Function	GO:0008134	transcription factor binding	Six2	IPI	UniProtKB:Q9WVG7	Mouse	MGI:MGI:5563874|PMID:24598167
Cellular Component	GO:0005634	nucleus	Six2	IDA		Mouse	PMID:15327782
Cellular Component	GO:0005634	nucleus	Six2	IDA		Mouse	PMID:8814301
Biological Process	GO:0009948	anterior/posterior axis specification	Six2	IDA		Mouse	MGI:MGI:3794506|PMID:18321982
Biological Process	GO:0016477	cell migration	SIX2	IDA		Human	PMID:22995329
Biological Process	GO:0008283	cell population proliferation	SIX2	IDA		Human	PMID:22995329
Biological Process	GO:0008283	cell population proliferation	Six2	IMP	MGI:MGI:3691857	Mouse	PMID:20515681
Biological Process	GO:0002062	chondrocyte differentiation	Six2	IMP	MGI:MGI:3691857	Mouse	PMID:20515681
Biological Process	GO:0072137	condensed mesenchymal cell proliferation	Six2	IGI	MGI:MGI:3045256	Mouse	PMID:26116661
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Six2	IMP	MGI:MGI:3691857	Mouse	PMID:20515681
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	Six2	IMP		Mouse	MGI:MGI:4365896|PMID:19660448
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Six2	IGI	MGI:MGI:96174	Mouse	PMID:15634706
Biological Process	GO:0030855	epithelial cell differentiation	Six2	IMP	MGI:MGI:3691857	Mouse	PMID:17036046
Biological Process	GO:0001822	kidney development	SIX2	IMP		Human	PMID:18305125
Biological Process	GO:0001822	kidney development	Six2	IMP		Mouse	MGI:MGI:3691408|PMID:17036046
Biological Process	GO:0072161	mesenchymal cell differentiation involved in kidney development	Six2	IMP		Mouse	MGI:MGI:3691408|PMID:17036046
Biological Process	GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis	Six2	IDA		Mouse	MGI:MGI:5442222|PMID:22902740
Biological Process	GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis	Six2	IMP		Mouse	MGI:MGI:4950307|PMID:21350016
Biological Process	GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis	Six2	IDA		Mouse	MGI:MGI:5563874|PMID:24598167
Biological Process	GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis	Six2	IMP		Mouse	MGI:MGI:3844906|PMID:18682239
Biological Process	GO:0097168	mesenchymal stem cell proliferation	Six2	IMP		Mouse	MGI:MGI:4950307|PMID:21350016
Biological Process	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	Six2	IEP		Mouse	MGI:MGI:1335967|PMID:10322633
Biological Process	GO:0007501	mesodermal cell fate specification	Six2	IDA		Mouse	MGI:MGI:3768605|PMID:17785448
Biological Process	GO:0001656	metanephros development	Six2	IMP	MGI:MGI:3691857	Mouse	PMID:17036046
Biological Process	GO:0042474	middle ear morphogenesis	Six2	IGI	MGI:MGI:96174	Mouse	PMID:15634706
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	Six2	IMP	MGI:MGI:3691857	Mouse	PMID:17036046
Biological Process	GO:0072006	nephron development	Six2	IMP		Mouse	MGI:MGI:3844906|PMID:18682239
Biological Process	GO:0072028	nephron morphogenesis	Six2	IMP		Mouse	MGI:MGI:3691408|PMID:17036046
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	Six2	IMP		Mouse	MGI:MGI:4822095|PMID:20515681
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Six2	IDA		Mouse	PMID:15327782
Biological Process	GO:0048793	pronephros development	six2a	IMP	ZFIN:ZDB-MRPHLNO-080919-2	Zfish	PMID:18305125
Biological Process	GO:0048793	pronephros development	six2a	IMP	ZFIN:ZDB-MRPHLNO-080919-3	Zfish	PMID:18305125
Biological Process	GO:0006606	protein import into nucleus	Six2	IDA		Mouse	PMID:16024294
Biological Process	GO:0090189	regulation of branching involved in ureteric bud morphogenesis	Six2	IMP		Mouse	MGI:MGI:3691408|PMID:17036046
Biological Process	GO:0032330	regulation of chondrocyte differentiation	Six2	IMP		Mouse	MGI:MGI:4822095|PMID:20515681
Biological Process	GO:0030278	regulation of ossification	Six2	IMP		Mouse	MGI:MGI:4822095|PMID:20515681

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern