Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Six3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SIX3
- Mouse genes Six3
- Rat genes Six3
- Zfish genes six3a,six3b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Six3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Six3	IDA		Mouse	PMID:12050133
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Six3	IDA		Mouse	MGI:MGI:3692850\|PMID:17066077
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Six3	IDA		Mouse	MGI:MGI:3718714\|PMID:17666527
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Six3	IDA		Mouse	PMID:12569128
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Six3	IDA		Mouse	PMID:17066077
Molecular Function	GO:0042826	histone deacetylase binding	Six3	IPI	UniProtKB:P70288	Mouse	MGI:MGI:3718714\|PMID:17666527
Molecular Function	GO:0005515	protein binding	SIX3	IPI	UniProtKB:Q92570	Human	PMID:12543801
Molecular Function	GO:0005515	protein binding	Six3	IPI	UniProtKB:O95677	Mouse	MGI:MGI:5582166\|PMID:19606496
Molecular Function	GO:0005515	protein binding	Six3	IPI	UniProtKB:P70288\|UniProtKB:Q8K4B0	Mouse	MGI:MGI:3718714\|PMID:17666527
Molecular Function	GO:0005515	protein binding	Six3	IPI	PR:P97767	Mouse	PMID:16024294
Molecular Function	GO:0005515	protein binding	Six3	IPI	PR:P63002	Mouse	PMID:12050133
Molecular Function	GO:0005515	protein binding	Six3	IPI	PR:Q62441	Mouse	PMID:12050133
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SIX3	IDA		Human	PMID:18836447
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Six3	IDA		Mouse	MGI:MGI:3692850\|PMID:17066077
Molecular Function	GO:0043565	sequence-specific DNA binding	Six3	IDA		Mouse	PMID:8814301
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SIX3	IDA		Human	PMID:28473536
Molecular Function	GO:0005102	signaling receptor binding	Six3	IMP		Rat	PMID:12493766\|RGD:1304266
Molecular Function	GO:0001222	transcription corepressor binding	SIX3	IPI	UniProtKB:Q04724	Human	PMID:12441302
Molecular Function	GO:0001222	transcription corepressor binding	SIX3	IPI	UniProtKB:Q08117	Human	PMID:12441302
Molecular Function	GO:0001222	transcription corepressor binding	SIX3	IPI	UniProtKB:Q709D5	Human	PMID:14973488
Molecular Function	GO:0001222	transcription corepressor binding	Six3	IPI	UniProtKB:Q8K4B0	Mouse	MGI:MGI:3718714\|PMID:17666527
Cellular Component	GO:0005634	nucleus	Six3	IDA		Mouse	PMID:16024294
Cellular Component	GO:0005634	nucleus	Six3	IDA		Mouse	PMID:8814301
Cellular Component	GO:0005634	nucleus	Six3	IDA		Mouse	PMID:12050133
Biological Process	GO:1902742	apoptotic process involved in development	Six3	IMP		Mouse	MGI:MGI:3813369\|PMID:18694563
Biological Process	GO:0007420	brain development	Six3	IMP	MGI:MGI:2450901	Mouse	PMID:12569128
Biological Process	GO:0007420	brain development	six3a	IMP	ZFIN:ZDB-MRPHLNO-051220-2	Zfish	PMID:16226737
Biological Process	GO:0007420	brain development	six3b	IMP	ZFIN:ZDB-MRPHLNO-051220-2	Zfish	PMID:16226737
Biological Process	GO:0043010	camera-type eye development	Six3	IGI	MGI:MGI:97490	Mouse	PMID:12072567
Biological Process	GO:0021846	cell proliferation in forebrain	Six3	IMP		Mouse	MGI:MGI:3813369\|PMID:18694563
Biological Process	GO:0048512	circadian behavior	Six3	IMP	MGI:MGI:3693321	Mouse	PMID:21525287
Biological Process	GO:0021536	diencephalon development	Six3	IGI	MGI:MGI:98953	Mouse	PMID:18094027
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	six3b	IGI	ZFIN:ZDB-GENO-080909-2,ZFIN:ZDB-MRPHLNO-071205-1	Zfish	PMID:18694563
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	six3b	IGI	ZFIN:ZDB-GENO-080909-1	Zfish	PMID:18694563
Biological Process	GO:0002070	epithelial cell maturation	Six3	IMP		Mouse	MGI:MGI:5299935\|PMID:22071110
Biological Process	GO:0001654	eye development	SIX3	IDA		Human	PMID:18791198
Biological Process	GO:0001654	eye development	Six3	IDA		Mouse	PMID:12050133
Biological Process	GO:0001654	eye development	six3b	IGI	ZFIN:ZDB-GENO-151102-11	Zfish	PMID:26180064
Biological Process	GO:0021797	forebrain anterior/posterior pattern specification	Six3	IMP	MGI:MGI:2450901	Mouse	PMID:18094027
Biological Process	GO:0021797	forebrain anterior/posterior pattern specification	Six3	IGI	MGI:MGI:98953	Mouse	PMID:18094027
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	SIX3	IDA		Human	PMID:18791198
Biological Process	GO:0008406	gonad development	Six3	IGI	MGI:MGI:96071	Mouse	PMID:18775421
Biological Process	GO:0002088	lens development in camera-type eye	Six3	IDA		Mouse	MGI:MGI:1929788\|PMID:11139622
Biological Process	GO:1990086	lens fiber cell apoptotic process	Six3	IDA		Mouse	MGI:MGI:2181466\|PMID:12072567
Biological Process	GO:0070306	lens fiber cell differentiation	Six3	IDA		Mouse	MGI:MGI:2181466\|PMID:12072567
Biological Process	GO:0060235	lens induction in camera-type eye	Six3	IMP	MGI:MGI:3693322	Mouse	PMID:17066077
Biological Process	GO:0035264	multicellular organism growth	Six3	IGI	MGI:MGI:96071	Mouse	PMID:18775421
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	SIX3	IDA		Human	PMID:18791198
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Six3	IDA		Mouse	MGI:MGI:1929788\|PMID:11139622
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Six3	IDA		Mouse	PMID:12050133
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Six3	IMP		Rat	PMID:12493766\|RGD:1304266
Biological Process	GO:0045665	negative regulation of neuron differentiation	Six3	IDA		Mouse	MGI:MGI:5582170\|PMID:17576749
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Six3	IMP	MGI:MGI:2450901	Mouse	PMID:12569128
Biological Process	GO:0014016	neuroblast differentiation	Six3	IMP		Mouse	MGI:MGI:5299935\|PMID:22071110
Biological Process	GO:0097402	neuroblast migration	Six3	IMP		Mouse	MGI:MGI:5299935\|PMID:22071110
Biological Process	GO:0021554	optic nerve development	six3a	IGI	ZFIN:ZDB-GENE-990415-128	Zfish	PMID:26822689
Biological Process	GO:0021554	optic nerve development	six3b	IGI	ZFIN:ZDB-GENE-990415-127	Zfish	PMID:26822689
Biological Process	GO:0021631	optic nerve morphogenesis	six3a	IGI	ZFIN:ZDB-GENE-990415-128	Zfish	PMID:26822689
Biological Process	GO:0021631	optic nerve morphogenesis	six3b	IGI	ZFIN:ZDB-GENE-990415-127	Zfish	PMID:26822689
Biological Process	GO:0003404	optic vesicle morphogenesis	Six3	IDA		Mouse	MGI:MGI:2136715\|PMID:11458394
Biological Process	GO:0021983	pituitary gland development	Six3	IMP		Mouse	MGI:MGI:3821506\|PMID:18775421
Biological Process	GO:0021983	pituitary gland development	Six3	IGI	MGI:MGI:96071	Mouse	PMID:18775421
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Six3	IDA		Mouse	PMID:17066077
Biological Process	GO:0006606	protein import into nucleus	Six3	IDA		Mouse	PMID:16024294
Biological Process	GO:0009946	proximal/distal axis specification	Six3	IDA		Mouse	MGI:MGI:5582181\|PMID:12163408
Biological Process	GO:1901987	regulation of cell cycle phase transition	Six3	IDA		Mouse	MGI:MGI:5582170\|PMID:17576749
Biological Process	GO:0042127	regulation of cell population proliferation	Six3	IMP		Mouse	MGI:MGI:3821506\|PMID:18775421
Biological Process	GO:2000177	regulation of neural precursor cell proliferation	Six3	IDA		Mouse	MGI:MGI:5582170\|PMID:17576749
Biological Process	GO:0061074	regulation of neural retina development	Six3	IMP		Mouse	MGI:MGI:4837018\|PMID:20890044
Biological Process	GO:1902692	regulation of neuroblast proliferation	Six3	IMP		Mouse	MGI:MGI:5299935\|PMID:22071110
Biological Process	GO:0070654	sensory epithelium regeneration	six3b	IGI	ZFIN:ZDB-GENO-131030-2	Zfish	PMID:23918319
Biological Process	GO:0021537	telencephalon development	Six3	IMP		Mouse	MGI:MGI:3813369\|PMID:18694563
Biological Process	GO:0021537	telencephalon development	Six3	IMP	MGI:MGI:2450901	Mouse	PMID:18094027
Biological Process	GO:0021978	telencephalon regionalization	Six3	IMP		Mouse	MGI:MGI:3813369\|PMID:18694563
Biological Process	GO:0030878	thyroid gland development	Six3	IGI	MGI:MGI:96071	Mouse	PMID:18775421

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.